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2PK9

Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0001676biological_processlong-chain fatty acid metabolic process
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005935cellular_componentcellular bud neck
A0005979biological_processregulation of glycogen biosynthetic process
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006974biological_processDNA damage response
A0009891biological_processpositive regulation of biosynthetic process
A0016239biological_processpositive regulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0019216biological_processregulation of lipid metabolic process
A0030952biological_processestablishment or maintenance of cytoskeleton polarity
A0031505biological_processfungal-type cell wall organization
A0031647biological_processregulation of protein stability
A0031648biological_processprotein destabilization
A0032878biological_processregulation of establishment or maintenance of cell polarity
A0032880biological_processregulation of protein localization
A0044843biological_processcell cycle G1/S phase transition
A0045719biological_processnegative regulation of glycogen biosynthetic process
A0045936biological_processnegative regulation of phosphate metabolic process
A0046822biological_processregulation of nucleocytoplasmic transport
A0050849biological_processnegative regulation of calcium-mediated signaling
A0051302biological_processregulation of cell division
A0051726biological_processregulation of cell cycle
A0055088biological_processlipid homeostasis
A0071073biological_processpositive regulation of phospholipid biosynthetic process
A0106310molecular_functionprotein serine kinase activity
A1901987biological_processregulation of cell cycle phase transition
A1902554cellular_componentserine/threonine protein kinase complex
A1990860cellular_componentPho85-Pho80 CDK-cyclin complex
B0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0016242biological_processnegative regulation of macroautophagy
B0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
B0019901molecular_functionprotein kinase binding
B0030003biological_processintracellular monoatomic cation homeostasis
B0032880biological_processregulation of protein localization
B0042144biological_processvacuole fusion, non-autophagic
B0045936biological_processnegative regulation of phosphate metabolic process
B0050849biological_processnegative regulation of calcium-mediated signaling
B1990860cellular_componentPho85-Pho80 CDK-cyclin complex
C0000082biological_processG1/S transition of mitotic cell cycle
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
C0001676biological_processlong-chain fatty acid metabolic process
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005935cellular_componentcellular bud neck
C0005979biological_processregulation of glycogen biosynthetic process
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0006468biological_processprotein phosphorylation
C0006974biological_processDNA damage response
C0009891biological_processpositive regulation of biosynthetic process
C0016239biological_processpositive regulation of macroautophagy
C0016242biological_processnegative regulation of macroautophagy
C0019216biological_processregulation of lipid metabolic process
C0030952biological_processestablishment or maintenance of cytoskeleton polarity
C0031505biological_processfungal-type cell wall organization
C0031647biological_processregulation of protein stability
C0031648biological_processprotein destabilization
C0032878biological_processregulation of establishment or maintenance of cell polarity
C0032880biological_processregulation of protein localization
C0044843biological_processcell cycle G1/S phase transition
C0045719biological_processnegative regulation of glycogen biosynthetic process
C0045936biological_processnegative regulation of phosphate metabolic process
C0046822biological_processregulation of nucleocytoplasmic transport
C0050849biological_processnegative regulation of calcium-mediated signaling
C0051302biological_processregulation of cell division
C0051726biological_processregulation of cell cycle
C0055088biological_processlipid homeostasis
C0071073biological_processpositive regulation of phospholipid biosynthetic process
C0106310molecular_functionprotein serine kinase activity
C1901987biological_processregulation of cell cycle phase transition
C1902554cellular_componentserine/threonine protein kinase complex
C1990860cellular_componentPho85-Pho80 CDK-cyclin complex
D0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0016242biological_processnegative regulation of macroautophagy
D0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
D0019901molecular_functionprotein kinase binding
D0030003biological_processintracellular monoatomic cation homeostasis
D0032880biological_processregulation of protein localization
D0042144biological_processvacuole fusion, non-autophagic
D0045936biological_processnegative regulation of phosphate metabolic process
D0050849biological_processnegative regulation of calcium-mediated signaling
D1990860cellular_componentPho85-Pho80 CDK-cyclin complex
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE MES B 294
ChainResidue
BILE75
BTYR80
BARG83
BGLY148
BGLY149
BVAL150
CPRO240
CLYS241

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MES D 294
ChainResidue
APRO240
ALYS241
DILE75
DTYR80
DARG83
DHIS120
DARG121
DGLY148
DGLY149
AGLY182

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGNGTYATVYkGlnkttgvy..........VALK
ChainResidueDetails
ALEU13-LYS36

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpqNLLI
ChainResidueDetails
AILE129-ILE141

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PHO85 => ECO:0000269|PubMed:15057567
ChainResidueDetails
BSER234
BSER267
DSER234
DSER267

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU13
ALYS36
CLEU13
CLYS36

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Not phosphorylated => ECO:0000269|PubMed:10490639
ChainResidueDetails
ASER166
ASER167
CSER166
CSER167

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10620010
ChainResidueDetails
ATYR18
CTYR18

site_idSWS_FT_FI5
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
ALYS289
CLYS289

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP133
AGLN137

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP133
CGLN137

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
ALYS135
AASP133

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CLYS135
CASP133

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
ALYS135
AASP133
ATHR171

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CLYS135
CASP133
CTHR171

site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASN138
ALYS135
AASP133

site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASN138
CLYS135
CASP133

222926

PDB entries from 2024-07-24

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