2PI2

Full-length Replication protein A subunits RPA14 and RPA32

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000077	biological_process	DNA damage checkpoint signaling
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005662	cellular_component	DNA replication factor A complex
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0010569	biological_process	regulation of double-strand break repair via homologous recombination
A	0016604	cellular_component	nuclear body
A	0016605	cellular_component	PML body
A	0019899	molecular_function	enzyme binding
A	0019903	molecular_function	protein phosphatase binding
A	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0034502	biological_process	protein localization to chromosome
A	0035861	cellular_component	site of double-strand break
A	0042162	molecular_function	telomeric DNA binding
A	0098505	molecular_function	G-rich strand telomeric DNA binding
A	2000001	biological_process	regulation of DNA damage checkpoint
B	0000077	biological_process	DNA damage checkpoint signaling
B	0000723	biological_process	telomere maintenance
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005662	cellular_component	DNA replication factor A complex
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006289	biological_process	nucleotide-excision repair
B	0006298	biological_process	mismatch repair
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0010569	biological_process	regulation of double-strand break repair via homologous recombination
B	0016604	cellular_component	nuclear body
B	0016605	cellular_component	PML body
B	0019899	molecular_function	enzyme binding
B	0019903	molecular_function	protein phosphatase binding
B	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0034502	biological_process	protein localization to chromosome
B	0035861	cellular_component	site of double-strand break
B	0042162	molecular_function	telomeric DNA binding
B	0098505	molecular_function	G-rich strand telomeric DNA binding
B	2000001	biological_process	regulation of DNA damage checkpoint
C	0000077	biological_process	DNA damage checkpoint signaling
C	0000723	biological_process	telomere maintenance
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005662	cellular_component	DNA replication factor A complex
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0006289	biological_process	nucleotide-excision repair
C	0006298	biological_process	mismatch repair
C	0006310	biological_process	DNA recombination
C	0006974	biological_process	DNA damage response
C	0010569	biological_process	regulation of double-strand break repair via homologous recombination
C	0016604	cellular_component	nuclear body
C	0016605	cellular_component	PML body
C	0019899	molecular_function	enzyme binding
C	0019903	molecular_function	protein phosphatase binding
C	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0034502	biological_process	protein localization to chromosome
C	0035861	cellular_component	site of double-strand break
C	0042162	molecular_function	telomeric DNA binding
C	0098505	molecular_function	G-rich strand telomeric DNA binding
C	2000001	biological_process	regulation of DNA damage checkpoint
D	0000077	biological_process	DNA damage checkpoint signaling
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000781	cellular_component	chromosome, telomeric region
D	0000785	cellular_component	chromatin
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005662	cellular_component	DNA replication factor A complex
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006289	biological_process	nucleotide-excision repair
D	0006298	biological_process	mismatch repair
D	0006310	biological_process	DNA recombination
D	0006974	biological_process	DNA damage response
D	0010569	biological_process	regulation of double-strand break repair via homologous recombination
D	0016604	cellular_component	nuclear body
D	0016605	cellular_component	PML body
D	0019899	molecular_function	enzyme binding
D	0019903	molecular_function	protein phosphatase binding
D	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0034502	biological_process	protein localization to chromosome
D	0035861	cellular_component	site of double-strand break
D	0042162	molecular_function	telomeric DNA binding
D	0098505	molecular_function	G-rich strand telomeric DNA binding
D	2000001	biological_process	regulation of DNA damage checkpoint
E	0000723	biological_process	telomere maintenance
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0003677	molecular_function	DNA binding
E	0003684	molecular_function	damaged DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005662	cellular_component	DNA replication factor A complex
E	0006260	biological_process	DNA replication
E	0006281	biological_process	DNA repair
E	0006284	biological_process	base-excision repair
E	0006289	biological_process	nucleotide-excision repair
E	0006298	biological_process	mismatch repair
E	0006310	biological_process	DNA recombination
E	0006974	biological_process	DNA damage response
E	0007346	biological_process	regulation of mitotic cell cycle
E	0035861	cellular_component	site of double-strand break
E	0042127	biological_process	regulation of cell population proliferation
F	0000723	biological_process	telomere maintenance
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0003677	molecular_function	DNA binding
F	0003684	molecular_function	damaged DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005662	cellular_component	DNA replication factor A complex
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0006284	biological_process	base-excision repair
F	0006289	biological_process	nucleotide-excision repair
F	0006298	biological_process	mismatch repair
F	0006310	biological_process	DNA recombination
F	0006974	biological_process	DNA damage response
F	0007346	biological_process	regulation of mitotic cell cycle
F	0035861	cellular_component	site of double-strand break
F	0042127	biological_process	regulation of cell population proliferation
G	0000723	biological_process	telomere maintenance
G	0000724	biological_process	double-strand break repair via homologous recombination
G	0003677	molecular_function	DNA binding
G	0003684	molecular_function	damaged DNA binding
G	0003697	molecular_function	single-stranded DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005662	cellular_component	DNA replication factor A complex
G	0006260	biological_process	DNA replication
G	0006281	biological_process	DNA repair
G	0006284	biological_process	base-excision repair
G	0006289	biological_process	nucleotide-excision repair
G	0006298	biological_process	mismatch repair
G	0006310	biological_process	DNA recombination
G	0006974	biological_process	DNA damage response
G	0007346	biological_process	regulation of mitotic cell cycle
G	0035861	cellular_component	site of double-strand break
G	0042127	biological_process	regulation of cell population proliferation
H	0000723	biological_process	telomere maintenance
H	0000724	biological_process	double-strand break repair via homologous recombination
H	0003677	molecular_function	DNA binding
H	0003684	molecular_function	damaged DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005662	cellular_component	DNA replication factor A complex
H	0006260	biological_process	DNA replication
H	0006281	biological_process	DNA repair
H	0006284	biological_process	base-excision repair
H	0006289	biological_process	nucleotide-excision repair
H	0006298	biological_process	mismatch repair
H	0006310	biological_process	DNA recombination
H	0006974	biological_process	DNA damage response
H	0007346	biological_process	regulation of mitotic cell cycle
H	0035861	cellular_component	site of double-strand break
H	0042127	biological_process	regulation of cell population proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DIO A 301

Chain	Residue
A	GLU123
A	THR124
A	TYR125
A	LEU149
A	MET152
E	VAL85
E	GLN86
E	PHE87
E	LYS88

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DIO B 302

Chain	Residue
B	GLU123
B	THR124
B	TYR125
B	LEU149
B	MET152
F	GLN86
F	LYS88

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DIO C 303

Chain	Residue
C	GLU123
C	THR124
C	TYR125
C	MET152
G	GLN86
G	LYS88

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DIO D 304

Chain	Residue
D	GLU123
D	THR124
D	TYR125
D	MET152
H	GLN86
H	LYS88

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"N-acetylvaline","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"26474068","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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