2PI2

Full-length Replication protein A subunits RPA14 and RPA32

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005662	cellular_component	DNA replication factor A complex
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006310	biological_process	DNA recombination
A	0010569	biological_process	regulation of double-strand break repair via homologous recombination
A	0016604	cellular_component	nuclear body
A	0016605	cellular_component	PML body
A	0019899	molecular_function	enzyme binding
A	0019903	molecular_function	protein phosphatase binding
A	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0034502	biological_process	protein localization to chromosome
A	0035861	cellular_component	site of double-strand break
A	0042162	molecular_function	telomeric DNA binding
A	0043229	cellular_component	intracellular organelle
A	0098505	molecular_function	G-rich strand telomeric DNA binding
A	2000001	biological_process	regulation of DNA damage checkpoint
B	0000723	biological_process	telomere maintenance
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005662	cellular_component	DNA replication factor A complex
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006289	biological_process	nucleotide-excision repair
B	0006298	biological_process	mismatch repair
B	0006310	biological_process	DNA recombination
B	0010569	biological_process	regulation of double-strand break repair via homologous recombination
B	0016604	cellular_component	nuclear body
B	0016605	cellular_component	PML body
B	0019899	molecular_function	enzyme binding
B	0019903	molecular_function	protein phosphatase binding
B	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0034502	biological_process	protein localization to chromosome
B	0035861	cellular_component	site of double-strand break
B	0042162	molecular_function	telomeric DNA binding
B	0043229	cellular_component	intracellular organelle
B	0098505	molecular_function	G-rich strand telomeric DNA binding
B	2000001	biological_process	regulation of DNA damage checkpoint
C	0000723	biological_process	telomere maintenance
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005662	cellular_component	DNA replication factor A complex
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0006289	biological_process	nucleotide-excision repair
C	0006298	biological_process	mismatch repair
C	0006310	biological_process	DNA recombination
C	0010569	biological_process	regulation of double-strand break repair via homologous recombination
C	0016604	cellular_component	nuclear body
C	0016605	cellular_component	PML body
C	0019899	molecular_function	enzyme binding
C	0019903	molecular_function	protein phosphatase binding
C	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0034502	biological_process	protein localization to chromosome
C	0035861	cellular_component	site of double-strand break
C	0042162	molecular_function	telomeric DNA binding
C	0043229	cellular_component	intracellular organelle
C	0098505	molecular_function	G-rich strand telomeric DNA binding
C	2000001	biological_process	regulation of DNA damage checkpoint
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000781	cellular_component	chromosome, telomeric region
D	0000785	cellular_component	chromatin
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005662	cellular_component	DNA replication factor A complex
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006289	biological_process	nucleotide-excision repair
D	0006298	biological_process	mismatch repair
D	0006310	biological_process	DNA recombination
D	0010569	biological_process	regulation of double-strand break repair via homologous recombination
D	0016604	cellular_component	nuclear body
D	0016605	cellular_component	PML body
D	0019899	molecular_function	enzyme binding
D	0019903	molecular_function	protein phosphatase binding
D	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0034502	biological_process	protein localization to chromosome
D	0035861	cellular_component	site of double-strand break
D	0042162	molecular_function	telomeric DNA binding
D	0043229	cellular_component	intracellular organelle
D	0098505	molecular_function	G-rich strand telomeric DNA binding
D	2000001	biological_process	regulation of DNA damage checkpoint
E	0000723	biological_process	telomere maintenance
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0003677	molecular_function	DNA binding
E	0003684	molecular_function	damaged DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005662	cellular_component	DNA replication factor A complex
E	0006260	biological_process	DNA replication
E	0006281	biological_process	DNA repair
E	0006284	biological_process	base-excision repair
E	0006289	biological_process	nucleotide-excision repair
E	0006298	biological_process	mismatch repair
E	0006310	biological_process	DNA recombination
E	0007346	biological_process	regulation of mitotic cell cycle
E	0031981	cellular_component	nuclear lumen
E	0035861	cellular_component	site of double-strand break
E	0042127	biological_process	regulation of cell population proliferation
F	0000723	biological_process	telomere maintenance
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0003677	molecular_function	DNA binding
F	0003684	molecular_function	damaged DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005662	cellular_component	DNA replication factor A complex
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0006284	biological_process	base-excision repair
F	0006289	biological_process	nucleotide-excision repair
F	0006298	biological_process	mismatch repair
F	0006310	biological_process	DNA recombination
F	0007346	biological_process	regulation of mitotic cell cycle
F	0031981	cellular_component	nuclear lumen
F	0035861	cellular_component	site of double-strand break
F	0042127	biological_process	regulation of cell population proliferation
G	0000723	biological_process	telomere maintenance
G	0000724	biological_process	double-strand break repair via homologous recombination
G	0003677	molecular_function	DNA binding
G	0003684	molecular_function	damaged DNA binding
G	0003697	molecular_function	single-stranded DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005662	cellular_component	DNA replication factor A complex
G	0006260	biological_process	DNA replication
G	0006281	biological_process	DNA repair
G	0006284	biological_process	base-excision repair
G	0006289	biological_process	nucleotide-excision repair
G	0006298	biological_process	mismatch repair
G	0006310	biological_process	DNA recombination
G	0007346	biological_process	regulation of mitotic cell cycle
G	0031981	cellular_component	nuclear lumen
G	0035861	cellular_component	site of double-strand break
G	0042127	biological_process	regulation of cell population proliferation
H	0000723	biological_process	telomere maintenance
H	0000724	biological_process	double-strand break repair via homologous recombination
H	0003677	molecular_function	DNA binding
H	0003684	molecular_function	damaged DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005662	cellular_component	DNA replication factor A complex
H	0006260	biological_process	DNA replication
H	0006281	biological_process	DNA repair
H	0006284	biological_process	base-excision repair
H	0006289	biological_process	nucleotide-excision repair
H	0006298	biological_process	mismatch repair
H	0006310	biological_process	DNA recombination
H	0007346	biological_process	regulation of mitotic cell cycle
H	0031981	cellular_component	nuclear lumen
H	0035861	cellular_component	site of double-strand break
H	0042127	biological_process	regulation of cell population proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DIO A 301

Chain	Residue
A	GLU123
A	THR124
A	TYR125
A	LEU149
A	MET152
E	VAL85
E	GLN86
E	PHE87
E	LYS88

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DIO B 302

Chain	Residue
B	GLU123
B	THR124
B	TYR125
B	LEU149
B	MET152
F	GLN86
F	LYS88

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DIO C 303

Chain	Residue
C	GLU123
C	THR124
C	TYR125
C	MET152
G	GLN86
G	LYS88

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DIO D 304

Chain	Residue
D	GLU123
D	THR124
D	TYR125
D	MET152
H	GLN86
H	LYS88

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylvaline => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
E	VAL2
F	VAL2
G	VAL2
H	VAL2

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26474068

Chain	Residue	Details
E	LYS23
G	LYS39
G	LYS88
H	LYS23
H	LYS39
H	LYS88
B	MET1
E	LYS39
E	LYS88
F	LYS23
F	LYS39
F	LYS88
G	LYS23

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:21731742, ECO:0000269|PubMed:26474068

Chain	Residue	Details
A	SER4
A	SER8
B	SER4
B	SER8
C	SER4
C	SER8
D	SER4
D	SER8

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PRKDC => ECO:0000269|PubMed:21558276, ECO:0000269|PubMed:26474068, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9295339

Chain	Residue	Details
A	THR21
B	THR21
C	THR21
D	THR21

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CDK2 => ECO:0000269|PubMed:1318195, ECO:0000269|PubMed:8246944, ECO:0000269|PubMed:9295339, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER23
B	SER23
C	SER23
D	SER23

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:1318195, ECO:0000269|PubMed:8246944, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9295339, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER29
B	SER29
C	SER29
D	SER29

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:26474068, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9295339

Chain	Residue	Details
A	SER33
B	SER33
C	SER33
D	SER33

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:26474068

Chain	Residue	Details
A	LYS37
D	LYS37
D	LYS38
A	LYS38
B	LYS37
B	LYS38
C	LYS37
C	LYS38

---