2PG1

Structural analysis of a cytoplasmic dynein Light Chain-Intermediate Chain complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000132	biological_process	establishment of mitotic spindle orientation
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005814	cellular_component	centriole
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005868	cellular_component	cytoplasmic dynein complex
A	0005874	cellular_component	microtubule
A	0005875	cellular_component	microtubule associated complex
A	0007017	biological_process	microtubule-based process
A	0007283	biological_process	spermatogenesis
A	0007290	biological_process	spermatid nucleus elongation
A	0007291	biological_process	sperm individualization
A	0007476	biological_process	imaginal disc-derived wing morphogenesis
A	0008407	biological_process	chaeta morphogenesis
A	0015630	cellular_component	microtubule cytoskeleton
A	0022416	biological_process	chaeta development
A	0030286	cellular_component	dynein complex
A	0032991	cellular_component	protein-containing complex
A	0034454	biological_process	microtubule anchoring at centrosome
A	0035220	biological_process	wing disc development
A	0042803	molecular_function	protein homodimerization activity
A	0045505	molecular_function	dynein intermediate chain binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0048477	biological_process	oogenesis
A	0051017	biological_process	actin filament bundle assembly
A	0051959	molecular_function	dynein light intermediate chain binding
A	0090571	cellular_component	RNA polymerase II transcription repressor complex
A	0097718	molecular_function	disordered domain specific binding
A	0141006	biological_process	piRNA-mediated retrotransposon silencing by heterochromatin formation
A	1904801	biological_process	positive regulation of neuron remodeling
B	0000132	biological_process	establishment of mitotic spindle orientation
B	0003714	molecular_function	transcription corepressor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005814	cellular_component	centriole
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005868	cellular_component	cytoplasmic dynein complex
B	0005874	cellular_component	microtubule
B	0005875	cellular_component	microtubule associated complex
B	0007017	biological_process	microtubule-based process
B	0007283	biological_process	spermatogenesis
B	0007290	biological_process	spermatid nucleus elongation
B	0007291	biological_process	sperm individualization
B	0007476	biological_process	imaginal disc-derived wing morphogenesis
B	0008407	biological_process	chaeta morphogenesis
B	0015630	cellular_component	microtubule cytoskeleton
B	0022416	biological_process	chaeta development
B	0030286	cellular_component	dynein complex
B	0032991	cellular_component	protein-containing complex
B	0034454	biological_process	microtubule anchoring at centrosome
B	0035220	biological_process	wing disc development
B	0042803	molecular_function	protein homodimerization activity
B	0045505	molecular_function	dynein intermediate chain binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0048477	biological_process	oogenesis
B	0051017	biological_process	actin filament bundle assembly
B	0051959	molecular_function	dynein light intermediate chain binding
B	0090571	cellular_component	RNA polymerase II transcription repressor complex
B	0097718	molecular_function	disordered domain specific binding
B	0141006	biological_process	piRNA-mediated retrotransposon silencing by heterochromatin formation
B	1904801	biological_process	positive regulation of neuron remodeling
C	0000132	biological_process	establishment of mitotic spindle orientation
C	0003714	molecular_function	transcription corepressor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005814	cellular_component	centriole
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005868	cellular_component	cytoplasmic dynein complex
C	0005874	cellular_component	microtubule
C	0005875	cellular_component	microtubule associated complex
C	0007017	biological_process	microtubule-based process
C	0007283	biological_process	spermatogenesis
C	0007290	biological_process	spermatid nucleus elongation
C	0007291	biological_process	sperm individualization
C	0007476	biological_process	imaginal disc-derived wing morphogenesis
C	0008407	biological_process	chaeta morphogenesis
C	0015630	cellular_component	microtubule cytoskeleton
C	0022416	biological_process	chaeta development
C	0030286	cellular_component	dynein complex
C	0032991	cellular_component	protein-containing complex
C	0034454	biological_process	microtubule anchoring at centrosome
C	0035220	biological_process	wing disc development
C	0042803	molecular_function	protein homodimerization activity
C	0045505	molecular_function	dynein intermediate chain binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0048477	biological_process	oogenesis
C	0051017	biological_process	actin filament bundle assembly
C	0051959	molecular_function	dynein light intermediate chain binding
C	0090571	cellular_component	RNA polymerase II transcription repressor complex
C	0097718	molecular_function	disordered domain specific binding
C	0141006	biological_process	piRNA-mediated retrotransposon silencing by heterochromatin formation
C	1904801	biological_process	positive regulation of neuron remodeling
D	0000132	biological_process	establishment of mitotic spindle orientation
D	0003714	molecular_function	transcription corepressor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005814	cellular_component	centriole
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005868	cellular_component	cytoplasmic dynein complex
D	0005874	cellular_component	microtubule
D	0005875	cellular_component	microtubule associated complex
D	0007017	biological_process	microtubule-based process
D	0007283	biological_process	spermatogenesis
D	0007290	biological_process	spermatid nucleus elongation
D	0007291	biological_process	sperm individualization
D	0007476	biological_process	imaginal disc-derived wing morphogenesis
D	0008407	biological_process	chaeta morphogenesis
D	0015630	cellular_component	microtubule cytoskeleton
D	0022416	biological_process	chaeta development
D	0030286	cellular_component	dynein complex
D	0032991	cellular_component	protein-containing complex
D	0034454	biological_process	microtubule anchoring at centrosome
D	0035220	biological_process	wing disc development
D	0042803	molecular_function	protein homodimerization activity
D	0045505	molecular_function	dynein intermediate chain binding
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0048477	biological_process	oogenesis
D	0051017	biological_process	actin filament bundle assembly
D	0051959	molecular_function	dynein light intermediate chain binding
D	0090571	cellular_component	RNA polymerase II transcription repressor complex
D	0097718	molecular_function	disordered domain specific binding
D	0141006	biological_process	piRNA-mediated retrotransposon silencing by heterochromatin formation
D	1904801	biological_process	positive regulation of neuron remodeling
E	0000278	biological_process	mitotic cell cycle
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005868	cellular_component	cytoplasmic dynein complex
E	0005874	cellular_component	microtubule
E	0007018	biological_process	microtubule-based movement
E	0007286	biological_process	spermatid development
E	0008090	biological_process	retrograde axonal transport
E	0008340	biological_process	determination of adult lifespan
E	0030286	cellular_component	dynein complex
E	0032991	cellular_component	protein-containing complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0045505	molecular_function	dynein intermediate chain binding
E	0051959	molecular_function	dynein light intermediate chain binding
E	0097718	molecular_function	disordered domain specific binding
E	1904115	cellular_component	axon cytoplasm
F	0000278	biological_process	mitotic cell cycle
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005868	cellular_component	cytoplasmic dynein complex
F	0005874	cellular_component	microtubule
F	0007018	biological_process	microtubule-based movement
F	0007286	biological_process	spermatid development
F	0008090	biological_process	retrograde axonal transport
F	0008340	biological_process	determination of adult lifespan
F	0030286	cellular_component	dynein complex
F	0032991	cellular_component	protein-containing complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0045505	molecular_function	dynein intermediate chain binding
F	0051959	molecular_function	dynein light intermediate chain binding
F	0097718	molecular_function	disordered domain specific binding
F	1904115	cellular_component	axon cytoplasm
G	0000278	biological_process	mitotic cell cycle
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005868	cellular_component	cytoplasmic dynein complex
G	0005874	cellular_component	microtubule
G	0007018	biological_process	microtubule-based movement
G	0007286	biological_process	spermatid development
G	0008090	biological_process	retrograde axonal transport
G	0008340	biological_process	determination of adult lifespan
G	0030286	cellular_component	dynein complex
G	0032991	cellular_component	protein-containing complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0045505	molecular_function	dynein intermediate chain binding
G	0051959	molecular_function	dynein light intermediate chain binding
G	0097718	molecular_function	disordered domain specific binding
G	1904115	cellular_component	axon cytoplasm
H	0000278	biological_process	mitotic cell cycle
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005868	cellular_component	cytoplasmic dynein complex
H	0005874	cellular_component	microtubule
H	0007018	biological_process	microtubule-based movement
H	0007286	biological_process	spermatid development
H	0008090	biological_process	retrograde axonal transport
H	0008340	biological_process	determination of adult lifespan
H	0030286	cellular_component	dynein complex
H	0032991	cellular_component	protein-containing complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0045505	molecular_function	dynein intermediate chain binding
H	0051959	molecular_function	dynein light intermediate chain binding
H	0097718	molecular_function	disordered domain specific binding
H	1904115	cellular_component	axon cytoplasm
I	0005868	cellular_component	cytoplasmic dynein complex
I	0007018	biological_process	microtubule-based movement
J	0005868	cellular_component	cytoplasmic dynein complex
J	0007018	biological_process	microtubule-based movement
K	0005868	cellular_component	cytoplasmic dynein complex
K	0007018	biological_process	microtubule-based movement
L	0005868	cellular_component	cytoplasmic dynein complex
L	0007018	biological_process	microtubule-based movement

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 112

Chain	Residue
G	THR92
G	VAL93
G	ARG94
G	HOH113
K	LYS116

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 90

Chain	Residue
C	SER14
C	GLU15
C	ARG71

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 90

Chain	Residue
D	GLY79
D	GLN80
D	ARG60

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 J 7

Chain	Residue
E	GLN43
J	TYR130
J	THR131

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 112

Chain	Residue
E	THR92
E	ARG94
G	ASN85
L	LYS116

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Functional Information from PROSITE/UniProt

site_id	PS01239
Number of Residues	15
Details	DYNEIN_LIGHT_1 Dynein light chain type 1 signature. HcIvGRnFGSyVTHE

Chain	Residue	Details
A	HIS55-GLU69

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