Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2PF4

Crystal structure of the full-length simian virus 40 small t antigen complexed with the protein phosphatase 2A Aalpha subunit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000159	cellular_component	protein phosphatase type 2A complex
A	0000775	cellular_component	chromosome, centromeric region
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007059	biological_process	chromosome segregation
A	0007143	biological_process	female meiotic nuclear division
A	0016328	cellular_component	lateral plasma membrane
A	0030425	cellular_component	dendrite
A	0035331	biological_process	negative regulation of hippo signaling
A	0042995	cellular_component	cell projection
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043029	biological_process	T cell homeostasis
A	0045202	cellular_component	synapse
A	0046982	molecular_function	protein heterodimerization activity
A	0051232	biological_process	meiotic spindle elongation
A	0051306	biological_process	mitotic sister chromatid separation
A	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
A	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0090443	cellular_component	FAR/SIN/STRIPAK complex
A	0098978	cellular_component	glutamatergic synapse
A	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
A	1990405	molecular_function	protein antigen binding
A	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B	0000159	cellular_component	protein phosphatase type 2A complex
B	0000775	cellular_component	chromosome, centromeric region
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0007059	biological_process	chromosome segregation
B	0007143	biological_process	female meiotic nuclear division
B	0016328	cellular_component	lateral plasma membrane
B	0030425	cellular_component	dendrite
B	0035331	biological_process	negative regulation of hippo signaling
B	0042995	cellular_component	cell projection
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0043029	biological_process	T cell homeostasis
B	0045202	cellular_component	synapse
B	0046982	molecular_function	protein heterodimerization activity
B	0051232	biological_process	meiotic spindle elongation
B	0051306	biological_process	mitotic sister chromatid separation
B	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
B	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0090443	cellular_component	FAR/SIN/STRIPAK complex
B	0098978	cellular_component	glutamatergic synapse
B	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
B	1990405	molecular_function	protein antigen binding
B	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
C	0000159	cellular_component	protein phosphatase type 2A complex
C	0000775	cellular_component	chromosome, centromeric region
C	0004722	molecular_function	protein serine/threonine phosphatase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0007059	biological_process	chromosome segregation
C	0007143	biological_process	female meiotic nuclear division
C	0016328	cellular_component	lateral plasma membrane
C	0030425	cellular_component	dendrite
C	0035331	biological_process	negative regulation of hippo signaling
C	0042995	cellular_component	cell projection
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0043029	biological_process	T cell homeostasis
C	0045202	cellular_component	synapse
C	0046982	molecular_function	protein heterodimerization activity
C	0051232	biological_process	meiotic spindle elongation
C	0051306	biological_process	mitotic sister chromatid separation
C	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
C	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0090443	cellular_component	FAR/SIN/STRIPAK complex
C	0098978	cellular_component	glutamatergic synapse
C	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
C	1990405	molecular_function	protein antigen binding
C	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
D	0000159	cellular_component	protein phosphatase type 2A complex
D	0000775	cellular_component	chromosome, centromeric region
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0007059	biological_process	chromosome segregation
D	0007143	biological_process	female meiotic nuclear division
D	0016328	cellular_component	lateral plasma membrane
D	0030425	cellular_component	dendrite
D	0035331	biological_process	negative regulation of hippo signaling
D	0042995	cellular_component	cell projection
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0043029	biological_process	T cell homeostasis
D	0045202	cellular_component	synapse
D	0046982	molecular_function	protein heterodimerization activity
D	0051232	biological_process	meiotic spindle elongation
D	0051306	biological_process	mitotic sister chromatid separation
D	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
D	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D	0090443	cellular_component	FAR/SIN/STRIPAK complex
D	0098978	cellular_component	glutamatergic synapse
D	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
D	1990405	molecular_function	protein antigen binding
D	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
E	0005515	molecular_function	protein binding
E	0030430	cellular_component	host cell cytoplasm
E	0039657	biological_process	symbiont-mediated suppression of host gene expression
E	0042025	cellular_component	host cell nucleus
E	0046872	molecular_function	metal ion binding
F	0005515	molecular_function	protein binding
F	0030430	cellular_component	host cell cytoplasm
F	0039657	biological_process	symbiont-mediated suppression of host gene expression
F	0042025	cellular_component	host cell nucleus
F	0046872	molecular_function	metal ion binding
G	0005515	molecular_function	protein binding
G	0030430	cellular_component	host cell cytoplasm
G	0039657	biological_process	symbiont-mediated suppression of host gene expression
G	0042025	cellular_component	host cell nucleus
G	0046872	molecular_function	metal ion binding
H	0005515	molecular_function	protein binding
H	0030430	cellular_component	host cell cytoplasm
H	0039657	biological_process	symbiont-mediated suppression of host gene expression
H	0042025	cellular_component	host cell nucleus
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 601

Chain	Residue
E	CYS103
E	CYS111
E	CYS113
E	CYS116

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 602

Chain	Residue
E	HIS122
E	CYS138
E	CYS140
E	CYS143

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 701

Chain	Residue
F	CYS111
F	CYS113
F	CYS116
F	CYS103

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 702

Chain	Residue
F	HIS122
F	CYS138
F	CYS140
F	CYS143

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 801

Chain	Residue
G	CYS103
G	CYS111
G	CYS113
G	CYS116

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 802

Chain	Residue
G	HIS122
G	CYS138
G	CYS140
G	CYS143

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 901

Chain	Residue
H	CYS103
H	CYS111
H	CYS113
H	CYS116

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 902

Chain	Residue
H	HIS122
H	CYS138
H	CYS140
H	CYS143

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	ZN_FING: C4-type; atypical

Chain	Residue	Details
E	CYS103-CYS116
F	CYS103-CYS116
G	CYS103-CYS116
H	CYS103-CYS116

site_id	SWS_FT_FI2
Number of Residues	84
Details	ZN_FING: H1C3-type; atypical

Chain	Residue	Details
E	HIS122-CYS143
F	HIS122-CYS143
G	HIS122-CYS143
H	HIS122-CYS143

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylmethionine; by host => ECO:0000269\|PubMed:205802

Chain	Residue	Details
E	MET1
F	MET1
G	MET1
H	MET1

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)