2PF4

Crystal structure of the full-length simian virus 40 small t antigen complexed with the protein phosphatase 2A Aalpha subunit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000159	cellular_component	protein phosphatase type 2A complex
A	0000775	cellular_component	chromosome, centromeric region
A	0000785	cellular_component	chromatin
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006366	biological_process	transcription by RNA polymerase II
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0007059	biological_process	chromosome segregation
A	0007143	biological_process	female meiotic nuclear division
A	0016328	cellular_component	lateral plasma membrane
A	0019888	molecular_function	protein phosphatase regulator activity
A	0030425	cellular_component	dendrite
A	0035331	biological_process	negative regulation of hippo signaling
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043029	biological_process	T cell homeostasis
A	0045202	cellular_component	synapse
A	0046982	molecular_function	protein heterodimerization activity
A	0051225	biological_process	spindle assembly
A	0051232	biological_process	meiotic spindle elongation
A	0051306	biological_process	mitotic sister chromatid separation
A	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
A	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0090443	cellular_component	FAR/SIN/STRIPAK complex
A	0098978	cellular_component	glutamatergic synapse
A	0160232	cellular_component	INTAC complex
A	0160240	biological_process	RNA polymerase II transcription initiation surveillance
A	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
A	1990405	molecular_function	protein antigen binding
A	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B	0000159	cellular_component	protein phosphatase type 2A complex
B	0000775	cellular_component	chromosome, centromeric region
B	0000785	cellular_component	chromatin
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006366	biological_process	transcription by RNA polymerase II
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0007059	biological_process	chromosome segregation
B	0007143	biological_process	female meiotic nuclear division
B	0016328	cellular_component	lateral plasma membrane
B	0019888	molecular_function	protein phosphatase regulator activity
B	0030425	cellular_component	dendrite
B	0035331	biological_process	negative regulation of hippo signaling
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0043029	biological_process	T cell homeostasis
B	0045202	cellular_component	synapse
B	0046982	molecular_function	protein heterodimerization activity
B	0051225	biological_process	spindle assembly
B	0051232	biological_process	meiotic spindle elongation
B	0051306	biological_process	mitotic sister chromatid separation
B	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
B	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0090443	cellular_component	FAR/SIN/STRIPAK complex
B	0098978	cellular_component	glutamatergic synapse
B	0160232	cellular_component	INTAC complex
B	0160240	biological_process	RNA polymerase II transcription initiation surveillance
B	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
B	1990405	molecular_function	protein antigen binding
B	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
C	0000159	cellular_component	protein phosphatase type 2A complex
C	0000775	cellular_component	chromosome, centromeric region
C	0000785	cellular_component	chromatin
C	0004722	molecular_function	protein serine/threonine phosphatase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006366	biological_process	transcription by RNA polymerase II
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0007059	biological_process	chromosome segregation
C	0007143	biological_process	female meiotic nuclear division
C	0016328	cellular_component	lateral plasma membrane
C	0019888	molecular_function	protein phosphatase regulator activity
C	0030425	cellular_component	dendrite
C	0035331	biological_process	negative regulation of hippo signaling
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0043029	biological_process	T cell homeostasis
C	0045202	cellular_component	synapse
C	0046982	molecular_function	protein heterodimerization activity
C	0051225	biological_process	spindle assembly
C	0051232	biological_process	meiotic spindle elongation
C	0051306	biological_process	mitotic sister chromatid separation
C	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
C	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0090443	cellular_component	FAR/SIN/STRIPAK complex
C	0098978	cellular_component	glutamatergic synapse
C	0160232	cellular_component	INTAC complex
C	0160240	biological_process	RNA polymerase II transcription initiation surveillance
C	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
C	1990405	molecular_function	protein antigen binding
C	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
D	0000159	cellular_component	protein phosphatase type 2A complex
D	0000775	cellular_component	chromosome, centromeric region
D	0000785	cellular_component	chromatin
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006366	biological_process	transcription by RNA polymerase II
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0007059	biological_process	chromosome segregation
D	0007143	biological_process	female meiotic nuclear division
D	0016328	cellular_component	lateral plasma membrane
D	0019888	molecular_function	protein phosphatase regulator activity
D	0030425	cellular_component	dendrite
D	0035331	biological_process	negative regulation of hippo signaling
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0043029	biological_process	T cell homeostasis
D	0045202	cellular_component	synapse
D	0046982	molecular_function	protein heterodimerization activity
D	0051225	biological_process	spindle assembly
D	0051232	biological_process	meiotic spindle elongation
D	0051306	biological_process	mitotic sister chromatid separation
D	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
D	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D	0090443	cellular_component	FAR/SIN/STRIPAK complex
D	0098978	cellular_component	glutamatergic synapse
D	0160232	cellular_component	INTAC complex
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
D	1990405	molecular_function	protein antigen binding
D	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
E	0005515	molecular_function	protein binding
E	0008270	molecular_function	zinc ion binding
E	0030430	cellular_component	host cell cytoplasm
E	0039657	biological_process	symbiont-mediated suppression of host gene expression
E	0042025	cellular_component	host cell nucleus
E	0046872	molecular_function	metal ion binding
F	0005515	molecular_function	protein binding
F	0008270	molecular_function	zinc ion binding
F	0030430	cellular_component	host cell cytoplasm
F	0039657	biological_process	symbiont-mediated suppression of host gene expression
F	0042025	cellular_component	host cell nucleus
F	0046872	molecular_function	metal ion binding
G	0005515	molecular_function	protein binding
G	0008270	molecular_function	zinc ion binding
G	0030430	cellular_component	host cell cytoplasm
G	0039657	biological_process	symbiont-mediated suppression of host gene expression
G	0042025	cellular_component	host cell nucleus
G	0046872	molecular_function	metal ion binding
H	0005515	molecular_function	protein binding
H	0008270	molecular_function	zinc ion binding
H	0030430	cellular_component	host cell cytoplasm
H	0039657	biological_process	symbiont-mediated suppression of host gene expression
H	0042025	cellular_component	host cell nucleus
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 601

Chain	Residue
E	CYS103
E	CYS111
E	CYS113
E	CYS116

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 602

Chain	Residue
E	HIS122
E	CYS138
E	CYS140
E	CYS143

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 701

Chain	Residue
F	CYS111
F	CYS113
F	CYS116
F	CYS103

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 702

Chain	Residue
F	HIS122
F	CYS138
F	CYS140
F	CYS143

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 801

Chain	Residue
G	CYS103
G	CYS111
G	CYS113
G	CYS116

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 802

Chain	Residue
G	HIS122
G	CYS138
G	CYS140
G	CYS143

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 901

Chain	Residue
H	CYS103
H	CYS111
H	CYS113
H	CYS116

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 902

Chain	Residue
H	HIS122
H	CYS138
H	CYS140
H	CYS143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	148
Details	Repeat: {"description":"HEAT 2","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	152
Details	Repeat: {"description":"HEAT 3","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	148
Details	Repeat: {"description":"HEAT 4","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	152
Details	Repeat: {"description":"HEAT 5","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	152
Details	Repeat: {"description":"HEAT 6","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	152
Details	Repeat: {"description":"HEAT 7","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	168
Details	Repeat: {"description":"HEAT 8","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	152
Details	Repeat: {"description":"HEAT 9","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	152
Details	Repeat: {"description":"HEAT 10","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	152
Details	Repeat: {"description":"HEAT 11","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	152
Details	Repeat: {"description":"HEAT 12","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	152
Details	Repeat: {"description":"HEAT 13","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	152
Details	Repeat: {"description":"HEAT 14","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	99
Details	Repeat: {"description":"HEAT 15","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	52
Details	Zinc finger: {"description":"C4-type; atypical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	84
Details	Zinc finger: {"description":"H1C3-type; atypical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Modified residue: {"description":"N-acetylmethionine; by host","evidences":[{"source":"PubMed","id":"205802","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---