2PB7
Crystal Structure of the SRA domain of the human UHRF1 protein
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ALA463 | |
| A | ASP469 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Required to confer preferential recognition of cytosine over thymine |
| Chain | Residue | Details |
| A | THR479 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Required to discriminate between hemimethylated DNA versus symmetrically methylated DNA |
| Chain | Residue | Details |
| A | ASN489 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Required for affinity and specificity for 5-mCpG sequence |
| Chain | Residue | Details |
| A | ARG491 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS546 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:22411829, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER639 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447 |
| Chain | Residue | Details |
| A | LYS546 |
