2P5T

Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0009636	biological_process	response to toxic substance
A	0015643	molecular_function	toxic substance binding
A	0031342	biological_process	negative regulation of cell killing
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
C	0003677	molecular_function	DNA binding
C	0009636	biological_process	response to toxic substance
C	0015643	molecular_function	toxic substance binding
C	0031342	biological_process	negative regulation of cell killing
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
E	0003677	molecular_function	DNA binding
E	0009636	biological_process	response to toxic substance
E	0015643	molecular_function	toxic substance binding
E	0031342	biological_process	negative regulation of cell killing
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
G	0003677	molecular_function	DNA binding
G	0009636	biological_process	response to toxic substance
G	0015643	molecular_function	toxic substance binding
G	0031342	biological_process	negative regulation of cell killing
H	0000166	molecular_function	nucleotide binding
H	0005524	molecular_function	ATP binding
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. ILLgGQSGAGKttI

Chain	Residue	Details
B	ILE35-ILE48

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17488720","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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