2P4U
Crystal structure of acid phosphatase 1 (Acp1) from Mus musculus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003993 | molecular_function | acid phosphatase activity |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0042383 | cellular_component | sarcolemma |
| B | 0003993 | molecular_function | acid phosphatase activity |
| B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0042383 | cellular_component | sarcolemma |
| C | 0003993 | molecular_function | acid phosphatase activity |
| C | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| C | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| C | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006470 | biological_process | protein dephosphorylation |
| C | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016791 | molecular_function | phosphatase activity |
| C | 0042383 | cellular_component | sarcolemma |
| D | 0003993 | molecular_function | acid phosphatase activity |
| D | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| D | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| D | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006470 | biological_process | protein dephosphorylation |
| D | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016791 | molecular_function | phosphatase activity |
| D | 0042383 | cellular_component | sarcolemma |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 201 |
| Chain | Residue |
| A | CYS13 |
| A | LEU14 |
| A | GLY15 |
| A | ASN16 |
| A | ILE17 |
| A | CYS18 |
| A | ARG19 |
| A | ASP130 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 B 201 |
| Chain | Residue |
| B | LEU14 |
| B | GLY15 |
| B | ASN16 |
| B | ILE17 |
| B | CYS18 |
| B | ARG19 |
| B | ASP130 |
| B | HOH244 |
| B | CYS13 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 C 201 |
| Chain | Residue |
| C | CYS13 |
| C | LEU14 |
| C | GLY15 |
| C | ASN16 |
| C | ILE17 |
| C | CYS18 |
| C | ARG19 |
| C | ASP130 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 D 201 |
| Chain | Residue |
| D | CYS13 |
| D | LEU14 |
| D | GLY15 |
| D | ASN16 |
| D | ILE17 |
| D | CYS18 |
| D | ARG19 |
| D | ASP130 |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 21 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Clr..CckaFlektyeghHhhh..H |
| Chain | Residue | Details |
| A | CYS146-HIS166 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P11064 |
| Chain | Residue | Details |
| A | CYS13 | |
| B | CYS13 | |
| C | CYS13 | |
| D | CYS13 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P11064 |
| Chain | Residue | Details |
| A | ARG19 | |
| B | ARG19 | |
| C | ARG19 | |
| D | ARG19 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P11064 |
| Chain | Residue | Details |
| A | ASP130 | |
| B | ASP130 | |
| C | ASP130 | |
| D | ASP130 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P11064 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P24666 |
| Chain | Residue | Details |
| A | TYR132 | |
| A | TYR133 | |
| B | TYR132 | |
| B | TYR133 | |
| C | TYR132 | |
| C | TYR133 | |
| D | TYR132 | |
| D | TYR133 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pnt |
| Chain | Residue | Details |
| A | CYS13 | |
| A | ARG19 | |
| A | CYS18 | |
| A | ASP130 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pnt |
| Chain | Residue | Details |
| B | CYS13 | |
| B | ARG19 | |
| B | CYS18 | |
| B | ASP130 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pnt |
| Chain | Residue | Details |
| C | CYS13 | |
| C | ARG19 | |
| C | CYS18 | |
| C | ASP130 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pnt |
| Chain | Residue | Details |
| D | CYS13 | |
| D | ARG19 | |
| D | CYS18 | |
| D | ASP130 |
