2P4D

Structure-assisted discovery of Variola major H1 phosphatase inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0030430	cellular_component	host cell cytoplasm
A	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
A	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
A	0044423	cellular_component	virion component
A	0052031	biological_process	symbiont-mediated perturbation of host defense response
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCvaGvnRSG

Chain	Residue	Details
A	VAL108-GLY118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---