Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 1001 |
| Chain | Residue |
| B | GLU284 |
| B | ASP291 |
| B | LEU312 |
| B | ASP314 |
| B | GLU316 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1002 |
| Chain | Residue |
| A | GLU316 |
| A | HOH1068 |
| A | GLU284 |
| A | ASP291 |
| A | LEU312 |
| A | ASP314 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1003 |
| Chain | Residue |
| A | LEU81 |
| A | GLY83 |
| A | ASP88 |
| A | GLU167 |
| A | HOH1007 |
| A | HOH1168 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 1004 |
| Chain | Residue |
| B | LEU81 |
| B | GLY83 |
| B | ASP88 |
| B | GLU167 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA A 1005 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR CHAIN D OF LEUPEPTIN |
| Chain | Residue |
| A | GLN91 |
| A | GLY95 |
| A | CYS97 |
| A | TRP98 |
| A | LYS188 |
| A | GLY189 |
| A | GLY190 |
| A | PHE233 |
| A | GLU243 |
| A | GLY253 |
| A | HOH1149 |
| B | GLN62 |
| B | ARG297 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR CHAIN E OF LEUPEPTIN |
| Chain | Residue |
| A | GLU59 |
| B | GLY95 |
| B | ASP96 |
| B | CYS97 |
| B | TRP98 |
| B | LYS188 |
| B | GLY189 |
| B | GLY190 |
| B | PHE233 |
| B | SER242 |
| B | GLY253 |
| B | HOH1105 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGeLGDCWLlAA |
| Chain | Residue | Details |
| A | GLN91-ALA102 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 590 |
| Details | Domain: {"description":"Calpain catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00239","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"17157313","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| A | CYS97 | |
| A | HIS254 | |
| A | ASN278 | |
| A | GLN91 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| B | CYS97 | |
| B | HIS254 | |
| B | ASN278 | |
| B | GLN91 | |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| A | CYS97 | |
| A | HIS254 | |
| A | ASN278 | |
| A | TRP280 | |
| A | GLN91 | |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| B | CYS97 | |
| B | HIS254 | |
| B | ASN278 | |
| B | TRP280 | |
| B | GLN91 | |
