2OXE

Structure of the Human Pancreatic Lipase-related Protein 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004465	molecular_function	lipoprotein lipase activity
A	0004620	molecular_function	phospholipase activity
A	0004806	molecular_function	triacylglycerol lipase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006641	biological_process	triglyceride metabolic process
A	0008970	molecular_function	phospholipase A1 activity
A	0009395	biological_process	phospholipid catabolic process
A	0016042	biological_process	lipid catabolic process
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0019376	biological_process	galactolipid catabolic process
A	0019433	biological_process	triglyceride catabolic process
A	0031410	cellular_component	cytoplasmic vesicle
A	0034375	biological_process	high-density lipoprotein particle remodeling
A	0034638	biological_process	phosphatidylcholine catabolic process
A	0042589	cellular_component	zymogen granule membrane
A	0042632	biological_process	cholesterol homeostasis
A	0043005	cellular_component	neuron projection
A	0044241	biological_process	lipid digestion
A	0046872	molecular_function	metal ion binding
A	0047372	molecular_function	monoacylglycerol lipase activity
A	0047714	molecular_function	galactolipase activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
B	0004465	molecular_function	lipoprotein lipase activity
B	0004620	molecular_function	phospholipase activity
B	0004806	molecular_function	triacylglycerol lipase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006629	biological_process	lipid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006641	biological_process	triglyceride metabolic process
B	0008970	molecular_function	phospholipase A1 activity
B	0009395	biological_process	phospholipid catabolic process
B	0016042	biological_process	lipid catabolic process
B	0016298	molecular_function	lipase activity
B	0016787	molecular_function	hydrolase activity
B	0019376	biological_process	galactolipid catabolic process
B	0019433	biological_process	triglyceride catabolic process
B	0031410	cellular_component	cytoplasmic vesicle
B	0034375	biological_process	high-density lipoprotein particle remodeling
B	0034638	biological_process	phosphatidylcholine catabolic process
B	0042589	cellular_component	zymogen granule membrane
B	0042632	biological_process	cholesterol homeostasis
B	0043005	cellular_component	neuron projection
B	0044241	biological_process	lipid digestion
B	0046872	molecular_function	metal ion binding
B	0047372	molecular_function	monoacylglycerol lipase activity
B	0047714	molecular_function	galactolipase activity
B	0052689	molecular_function	carboxylic ester hydrolase activity

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VHVIGHSLGA

Chain	Residue	Details
A	VAL165-ALA174

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Region: {"description":"Required for galactolipase activity","evidences":[{"source":"PubMed","id":"26494624","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"18702514","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU10037","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18702514","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18702514","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PVS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18702514","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OXE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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