2OXE

Structure of the Human Pancreatic Lipase-related Protein 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004620	molecular_function	phospholipase activity
A	0004806	molecular_function	triglyceride lipase activity
A	0005509	molecular_function	calcium ion binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0006641	biological_process	triglyceride metabolic process
A	0009395	biological_process	phospholipid catabolic process
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0019376	biological_process	galactolipid catabolic process
A	0019433	biological_process	triglyceride catabolic process
A	0031410	cellular_component	cytoplasmic vesicle
A	0034638	biological_process	phosphatidylcholine catabolic process
A	0042589	cellular_component	zymogen granule membrane
A	0042995	cellular_component	cell projection
A	0043005	cellular_component	neuron projection
A	0044241	biological_process	lipid digestion
A	0046872	molecular_function	metal ion binding
A	0047372	molecular_function	acylglycerol lipase activity
A	0047714	molecular_function	galactolipase activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	0102549	molecular_function	1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity
B	0004620	molecular_function	phospholipase activity
B	0004806	molecular_function	triglyceride lipase activity
B	0005509	molecular_function	calcium ion binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006629	biological_process	lipid metabolic process
B	0006641	biological_process	triglyceride metabolic process
B	0009395	biological_process	phospholipid catabolic process
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016298	molecular_function	lipase activity
B	0016787	molecular_function	hydrolase activity
B	0019376	biological_process	galactolipid catabolic process
B	0019433	biological_process	triglyceride catabolic process
B	0031410	cellular_component	cytoplasmic vesicle
B	0034638	biological_process	phosphatidylcholine catabolic process
B	0042589	cellular_component	zymogen granule membrane
B	0042995	cellular_component	cell projection
B	0043005	cellular_component	neuron projection
B	0044241	biological_process	lipid digestion
B	0046872	molecular_function	metal ion binding
B	0047372	molecular_function	acylglycerol lipase activity
B	0047714	molecular_function	galactolipase activity
B	0052689	molecular_function	carboxylic ester hydrolase activity
B	0102549	molecular_function	1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VHVIGHSLGA

Chain	Residue	Details
A	VAL165-ALA174

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:18702514

Chain	Residue	Details
A	SER171
B	SER171

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10037, ECO:0000269|PubMed:18702514

Chain	Residue	Details
A	ASP195
A	HIS282
B	ASP195
B	HIS282

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:18702514, ECO:0007744|PDB:2OXE, ECO:0007744|PDB:2PVS

Chain	Residue	Details
A	GLU206
A	ARG209
A	ASP211
A	ASP214
B	GLU206
B	ARG209
B	ASP211
B	ASP214

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18702514, ECO:0007744|PDB:2OXE

Chain	Residue	Details
A	ASN353
B	ASN353

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN428
B	ASN428

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