2OV2

The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0007015	biological_process	actin filament organization
A	0007163	biological_process	establishment or maintenance of cell polarity
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0008045	biological_process	motor neuron axon guidance
A	0008360	biological_process	regulation of cell shape
A	0010810	biological_process	regulation of cell-substrate adhesion
A	0012505	cellular_component	endomembrane system
A	0016055	biological_process	Wnt signaling pathway
A	0016601	biological_process	Rac protein signal transduction
A	0016787	molecular_function	hydrolase activity
A	0019901	molecular_function	protein kinase binding
A	0030027	cellular_component	lamellipodium
A	0030031	biological_process	cell projection assembly
A	0030036	biological_process	actin cytoskeleton organization
A	0030426	cellular_component	growth cone
A	0030865	biological_process	cortical cytoskeleton organization
A	0031410	cellular_component	cytoplasmic vesicle
A	0031941	cellular_component	filamentous actin
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
A	0035556	biological_process	intracellular signal transduction
A	0043005	cellular_component	neuron projection
A	0043020	cellular_component	NADPH oxidase complex
A	0043025	cellular_component	neuronal cell body
A	0045730	biological_process	respiratory burst
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0060326	biological_process	cell chemotaxis
A	0070062	cellular_component	extracellular exosome
A	0071944	cellular_component	cell periphery
A	0098794	cellular_component	postsynapse
A	0098974	biological_process	postsynaptic actin cytoskeleton organization
A	0098978	cellular_component	glutamatergic synapse
A	0150052	biological_process	regulation of postsynapse assembly
A	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
A	1902622	biological_process	regulation of neutrophil migration
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0007015	biological_process	actin filament organization
B	0007163	biological_process	establishment or maintenance of cell polarity
B	0007264	biological_process	small GTPase-mediated signal transduction
B	0008045	biological_process	motor neuron axon guidance
B	0008360	biological_process	regulation of cell shape
B	0010810	biological_process	regulation of cell-substrate adhesion
B	0012505	cellular_component	endomembrane system
B	0016055	biological_process	Wnt signaling pathway
B	0016601	biological_process	Rac protein signal transduction
B	0016787	molecular_function	hydrolase activity
B	0019901	molecular_function	protein kinase binding
B	0030027	cellular_component	lamellipodium
B	0030031	biological_process	cell projection assembly
B	0030036	biological_process	actin cytoskeleton organization
B	0030426	cellular_component	growth cone
B	0030865	biological_process	cortical cytoskeleton organization
B	0031410	cellular_component	cytoplasmic vesicle
B	0031941	cellular_component	filamentous actin
B	0032956	biological_process	regulation of actin cytoskeleton organization
B	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
B	0035556	biological_process	intracellular signal transduction
B	0043005	cellular_component	neuron projection
B	0043020	cellular_component	NADPH oxidase complex
B	0043025	cellular_component	neuronal cell body
B	0045730	biological_process	respiratory burst
B	0048306	molecular_function	calcium-dependent protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0060326	biological_process	cell chemotaxis
B	0070062	cellular_component	extracellular exosome
B	0071944	cellular_component	cell periphery
B	0098794	cellular_component	postsynapse
B	0098974	biological_process	postsynaptic actin cytoskeleton organization
B	0098978	cellular_component	glutamatergic synapse
B	0150052	biological_process	regulation of postsynapse assembly
B	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
B	1902622	biological_process	regulation of neutrophil migration
C	0000166	molecular_function	nucleotide binding
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0007015	biological_process	actin filament organization
C	0007163	biological_process	establishment or maintenance of cell polarity
C	0007264	biological_process	small GTPase-mediated signal transduction
C	0008045	biological_process	motor neuron axon guidance
C	0008360	biological_process	regulation of cell shape
C	0010810	biological_process	regulation of cell-substrate adhesion
C	0012505	cellular_component	endomembrane system
C	0016055	biological_process	Wnt signaling pathway
C	0016601	biological_process	Rac protein signal transduction
C	0016787	molecular_function	hydrolase activity
C	0019901	molecular_function	protein kinase binding
C	0030027	cellular_component	lamellipodium
C	0030031	biological_process	cell projection assembly
C	0030036	biological_process	actin cytoskeleton organization
C	0030426	cellular_component	growth cone
C	0030865	biological_process	cortical cytoskeleton organization
C	0031410	cellular_component	cytoplasmic vesicle
C	0031941	cellular_component	filamentous actin
C	0032956	biological_process	regulation of actin cytoskeleton organization
C	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
C	0035556	biological_process	intracellular signal transduction
C	0043005	cellular_component	neuron projection
C	0043020	cellular_component	NADPH oxidase complex
C	0043025	cellular_component	neuronal cell body
C	0045730	biological_process	respiratory burst
C	0048306	molecular_function	calcium-dependent protein binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0060326	biological_process	cell chemotaxis
C	0070062	cellular_component	extracellular exosome
C	0071944	cellular_component	cell periphery
C	0098794	cellular_component	postsynapse
C	0098974	biological_process	postsynaptic actin cytoskeleton organization
C	0098978	cellular_component	glutamatergic synapse
C	0150052	biological_process	regulation of postsynapse assembly
C	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
C	1902622	biological_process	regulation of neutrophil migration
D	0000166	molecular_function	nucleotide binding
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0007015	biological_process	actin filament organization
D	0007163	biological_process	establishment or maintenance of cell polarity
D	0007264	biological_process	small GTPase-mediated signal transduction
D	0008045	biological_process	motor neuron axon guidance
D	0008360	biological_process	regulation of cell shape
D	0010810	biological_process	regulation of cell-substrate adhesion
D	0012505	cellular_component	endomembrane system
D	0016055	biological_process	Wnt signaling pathway
D	0016601	biological_process	Rac protein signal transduction
D	0016787	molecular_function	hydrolase activity
D	0019901	molecular_function	protein kinase binding
D	0030027	cellular_component	lamellipodium
D	0030031	biological_process	cell projection assembly
D	0030036	biological_process	actin cytoskeleton organization
D	0030426	cellular_component	growth cone
D	0030865	biological_process	cortical cytoskeleton organization
D	0031410	cellular_component	cytoplasmic vesicle
D	0031941	cellular_component	filamentous actin
D	0032956	biological_process	regulation of actin cytoskeleton organization
D	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
D	0035556	biological_process	intracellular signal transduction
D	0043005	cellular_component	neuron projection
D	0043020	cellular_component	NADPH oxidase complex
D	0043025	cellular_component	neuronal cell body
D	0045730	biological_process	respiratory burst
D	0048306	molecular_function	calcium-dependent protein binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0060326	biological_process	cell chemotaxis
D	0070062	cellular_component	extracellular exosome
D	0071944	cellular_component	cell periphery
D	0098794	cellular_component	postsynapse
D	0098974	biological_process	postsynaptic actin cytoskeleton organization
D	0098978	cellular_component	glutamatergic synapse
D	0150052	biological_process	regulation of postsynapse assembly
D	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
D	1902622	biological_process	regulation of neutrophil migration
E	0000166	molecular_function	nucleotide binding
E	0003924	molecular_function	GTPase activity
E	0003925	molecular_function	G protein activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0007015	biological_process	actin filament organization
E	0007163	biological_process	establishment or maintenance of cell polarity
E	0007264	biological_process	small GTPase-mediated signal transduction
E	0008045	biological_process	motor neuron axon guidance
E	0008360	biological_process	regulation of cell shape
E	0010810	biological_process	regulation of cell-substrate adhesion
E	0012505	cellular_component	endomembrane system
E	0016055	biological_process	Wnt signaling pathway
E	0016601	biological_process	Rac protein signal transduction
E	0016787	molecular_function	hydrolase activity
E	0019901	molecular_function	protein kinase binding
E	0030027	cellular_component	lamellipodium
E	0030031	biological_process	cell projection assembly
E	0030036	biological_process	actin cytoskeleton organization
E	0030426	cellular_component	growth cone
E	0030865	biological_process	cortical cytoskeleton organization
E	0031410	cellular_component	cytoplasmic vesicle
E	0031941	cellular_component	filamentous actin
E	0032956	biological_process	regulation of actin cytoskeleton organization
E	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
E	0035556	biological_process	intracellular signal transduction
E	0043005	cellular_component	neuron projection
E	0043020	cellular_component	NADPH oxidase complex
E	0043025	cellular_component	neuronal cell body
E	0045730	biological_process	respiratory burst
E	0048306	molecular_function	calcium-dependent protein binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0060326	biological_process	cell chemotaxis
E	0070062	cellular_component	extracellular exosome
E	0071944	cellular_component	cell periphery
E	0098794	cellular_component	postsynapse
E	0098974	biological_process	postsynaptic actin cytoskeleton organization
E	0098978	cellular_component	glutamatergic synapse
E	0150052	biological_process	regulation of postsynapse assembly
E	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
E	1902622	biological_process	regulation of neutrophil migration
F	0000166	molecular_function	nucleotide binding
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0007015	biological_process	actin filament organization
F	0007163	biological_process	establishment or maintenance of cell polarity
F	0007264	biological_process	small GTPase-mediated signal transduction
F	0008045	biological_process	motor neuron axon guidance
F	0008360	biological_process	regulation of cell shape
F	0010810	biological_process	regulation of cell-substrate adhesion
F	0012505	cellular_component	endomembrane system
F	0016055	biological_process	Wnt signaling pathway
F	0016601	biological_process	Rac protein signal transduction
F	0016787	molecular_function	hydrolase activity
F	0019901	molecular_function	protein kinase binding
F	0030027	cellular_component	lamellipodium
F	0030031	biological_process	cell projection assembly
F	0030036	biological_process	actin cytoskeleton organization
F	0030426	cellular_component	growth cone
F	0030865	biological_process	cortical cytoskeleton organization
F	0031410	cellular_component	cytoplasmic vesicle
F	0031941	cellular_component	filamentous actin
F	0032956	biological_process	regulation of actin cytoskeleton organization
F	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
F	0035556	biological_process	intracellular signal transduction
F	0043005	cellular_component	neuron projection
F	0043020	cellular_component	NADPH oxidase complex
F	0043025	cellular_component	neuronal cell body
F	0045730	biological_process	respiratory burst
F	0048306	molecular_function	calcium-dependent protein binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0060326	biological_process	cell chemotaxis
F	0070062	cellular_component	extracellular exosome
F	0071944	cellular_component	cell periphery
F	0098794	cellular_component	postsynapse
F	0098974	biological_process	postsynaptic actin cytoskeleton organization
F	0098978	cellular_component	glutamatergic synapse
F	0150052	biological_process	regulation of postsynapse assembly
F	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
F	1902622	biological_process	regulation of neutrophil migration
G	0000166	molecular_function	nucleotide binding
G	0003924	molecular_function	GTPase activity
G	0003925	molecular_function	G protein activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0007015	biological_process	actin filament organization
G	0007163	biological_process	establishment or maintenance of cell polarity
G	0007264	biological_process	small GTPase-mediated signal transduction
G	0008045	biological_process	motor neuron axon guidance
G	0008360	biological_process	regulation of cell shape
G	0010810	biological_process	regulation of cell-substrate adhesion
G	0012505	cellular_component	endomembrane system
G	0016055	biological_process	Wnt signaling pathway
G	0016601	biological_process	Rac protein signal transduction
G	0016787	molecular_function	hydrolase activity
G	0019901	molecular_function	protein kinase binding
G	0030027	cellular_component	lamellipodium
G	0030031	biological_process	cell projection assembly
G	0030036	biological_process	actin cytoskeleton organization
G	0030426	cellular_component	growth cone
G	0030865	biological_process	cortical cytoskeleton organization
G	0031410	cellular_component	cytoplasmic vesicle
G	0031941	cellular_component	filamentous actin
G	0032956	biological_process	regulation of actin cytoskeleton organization
G	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
G	0035556	biological_process	intracellular signal transduction
G	0043005	cellular_component	neuron projection
G	0043020	cellular_component	NADPH oxidase complex
G	0043025	cellular_component	neuronal cell body
G	0045730	biological_process	respiratory burst
G	0048306	molecular_function	calcium-dependent protein binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0060326	biological_process	cell chemotaxis
G	0070062	cellular_component	extracellular exosome
G	0071944	cellular_component	cell periphery
G	0098794	cellular_component	postsynapse
G	0098974	biological_process	postsynaptic actin cytoskeleton organization
G	0098978	cellular_component	glutamatergic synapse
G	0150052	biological_process	regulation of postsynapse assembly
G	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
G	1902622	biological_process	regulation of neutrophil migration
H	0000166	molecular_function	nucleotide binding
H	0003924	molecular_function	GTPase activity
H	0003925	molecular_function	G protein activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0007015	biological_process	actin filament organization
H	0007163	biological_process	establishment or maintenance of cell polarity
H	0007264	biological_process	small GTPase-mediated signal transduction
H	0008045	biological_process	motor neuron axon guidance
H	0008360	biological_process	regulation of cell shape
H	0010810	biological_process	regulation of cell-substrate adhesion
H	0012505	cellular_component	endomembrane system
H	0016055	biological_process	Wnt signaling pathway
H	0016601	biological_process	Rac protein signal transduction
H	0016787	molecular_function	hydrolase activity
H	0019901	molecular_function	protein kinase binding
H	0030027	cellular_component	lamellipodium
H	0030031	biological_process	cell projection assembly
H	0030036	biological_process	actin cytoskeleton organization
H	0030426	cellular_component	growth cone
H	0030865	biological_process	cortical cytoskeleton organization
H	0031410	cellular_component	cytoplasmic vesicle
H	0031941	cellular_component	filamentous actin
H	0032956	biological_process	regulation of actin cytoskeleton organization
H	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
H	0035556	biological_process	intracellular signal transduction
H	0043005	cellular_component	neuron projection
H	0043020	cellular_component	NADPH oxidase complex
H	0043025	cellular_component	neuronal cell body
H	0045730	biological_process	respiratory burst
H	0048306	molecular_function	calcium-dependent protein binding
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0060326	biological_process	cell chemotaxis
H	0070062	cellular_component	extracellular exosome
H	0071944	cellular_component	cell periphery
H	0098794	cellular_component	postsynapse
H	0098974	biological_process	postsynaptic actin cytoskeleton organization
H	0098978	cellular_component	glutamatergic synapse
H	0150052	biological_process	regulation of postsynapse assembly
H	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
H	1902622	biological_process	regulation of neutrophil migration
I	0004674	molecular_function	protein serine/threonine kinase activity
J	0004674	molecular_function	protein serine/threonine kinase activity
K	0004674	molecular_function	protein serine/threonine kinase activity
L	0004674	molecular_function	protein serine/threonine kinase activity
M	0004674	molecular_function	protein serine/threonine kinase activity
N	0004674	molecular_function	protein serine/threonine kinase activity
O	0004674	molecular_function	protein serine/threonine kinase activity
P	0004674	molecular_function	protein serine/threonine kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 202

Chain	Residue
A	THR17
A	THR35
A	GCP200
A	HOH1222
A	HOH1250

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F 202

Chain	Residue
F	HOH1334
F	THR17
F	THR35
F	GCP200
F	HOH1302

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 202

Chain	Residue
B	THR17
B	THR35
B	GCP200
B	HOH1220
B	HOH1253

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 202

Chain	Residue
C	THR17
C	THR35
C	GCP200
C	HOH1308
C	HOH1360

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 202

Chain	Residue
G	THR17
G	THR35
G	GCP200
G	HOH236
G	HOH249

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 202

Chain	Residue
D	THR17
D	THR35
D	GCP200
D	HOH1317
D	HOH1328

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 202

Chain	Residue
E	THR17
E	THR35
E	GCP200
E	HOH1242
E	HOH1249

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG H 202

Chain	Residue
H	THR17
H	THR35
H	GCP200
H	HOH217
H	HOH263

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1201

Chain	Residue
A	SER151

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1203

Chain	Residue
B	HOH1213
C	ARG102

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 1204

Chain	Residue
B	SER22
B	LEU160

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL P 1205

Chain	Residue
P	GLN27

---

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL N 1206

Chain	Residue
N	PRO14

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL O 1209

Chain	Residue
O	GLN27
O	HOH759

---

site_id	BC6
Number of Residues	30
Details	BINDING SITE FOR RESIDUE GCP A 200

Chain	Residue
A	ALA13
A	VAL14
A	GLY15
A	LYS16
A	THR17
A	CYS18
A	PHE28
A	TYR32
A	PRO34
A	THR35
A	GLY60
A	LYS116
A	ASP118
A	LEU119
A	SER158
A	ALA159
A	LEU160
A	MG202
A	HOH1208
A	HOH1209
A	HOH1210
A	HOH1221
A	HOH1222
A	HOH1227
A	HOH1234
A	HOH1250
A	HOH1254
A	HOH1283
A	HOH1290
J	GLN27

---

site_id	BC7
Number of Residues	29
Details	BINDING SITE FOR RESIDUE GCP F 200

Chain	Residue
F	HOH1303
F	HOH1319
F	HOH1332
F	HOH1333
F	HOH1334
F	HOH1335
G	HOH207
O	GLN27
O	HOH586
F	ALA13
F	VAL14
F	GLY15
F	LYS16
F	THR17
F	CYS18
F	PHE28
F	TYR32
F	PRO34
F	THR35
F	GLY60
F	LYS116
F	ASP118
F	LEU119
F	SER158
F	ALA159
F	LEU160
F	MG202
F	EDO1301
F	HOH1302

---

site_id	BC8
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GCP B 200

Chain	Residue
A	HOH1241
B	ALA13
B	VAL14
B	GLY15
B	LYS16
B	THR17
B	CYS18
B	PHE28
B	TYR32
B	PRO34
B	THR35
B	GLY60
B	LYS116
B	ASP118
B	LEU119
B	SER158
B	ALA159
B	LEU160
B	MG202
B	HOH1205
B	HOH1209
B	HOH1219
B	HOH1220
B	HOH1226
B	HOH1228
B	HOH1232
B	HOH1253
I	GLN27

---

site_id	BC9
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GCP C 200

Chain	Residue
C	ALA13
C	VAL14
C	GLY15
C	LYS16
C	THR17
C	CYS18
C	PHE28
C	TYR32
C	PRO34
C	THR35
C	GLY60
C	LYS116
C	ASP118
C	LEU119
C	SER158
C	ALA159
C	LEU160
C	MG202
C	EDO1302
C	HOH1303
C	HOH1307
C	HOH1308
C	HOH1321
C	HOH1330
C	HOH1338
C	HOH1339
C	HOH1360
L	GLN27

---

site_id	CC1
Number of Residues	29
Details	BINDING SITE FOR RESIDUE GCP G 200

Chain	Residue
F	HOH1304
G	ALA13
G	VAL14
G	GLY15
G	LYS16
G	THR17
G	CYS18
G	PHE28
G	TYR32
G	PRO34
G	THR35
G	GLY60
G	LYS116
G	ASP118
G	LEU119
G	SER158
G	ALA159
G	LEU160
G	MG202
G	HOH203
G	HOH204
G	HOH213
G	HOH221
G	HOH225
G	HOH236
G	HOH237
G	HOH249
N	GLN27
N	HOH530

---

site_id	CC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GCP D 200

Chain	Residue
D	ALA13
D	VAL14
D	GLY15
D	LYS16
D	THR17
D	CYS18
D	PHE28
D	TYR32
D	PRO34
D	THR35
D	GLY60
D	LYS116
D	ASP118
D	SER158
D	ALA159
D	LEU160
D	MG202
D	EDO1303
D	HOH1305
D	HOH1317
D	HOH1328
D	HOH1330
D	HOH1333
D	HOH1334
D	HOH1339
D	HOH1340
K	GLN27

---

site_id	CC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GCP E 200

Chain	Residue
E	ALA13
E	VAL14
E	GLY15
E	LYS16
E	THR17
E	CYS18
E	PHE28
E	TYR32
E	PRO34
E	THR35
E	GLY60
E	LYS116
E	ASP118
E	LEU119
E	SER158
E	ALA159
E	LEU160
E	MG202
E	HOH1209
E	HOH1213
E	HOH1215
E	HOH1216
E	HOH1240
E	HOH1242
E	HOH1249
E	HOH1259
H	HOH208
P	GLN27

---

site_id	CC4
Number of Residues	30
Details	BINDING SITE FOR RESIDUE GCP H 200

Chain	Residue
E	HOH1225
H	ALA13
H	VAL14
H	GLY15
H	LYS16
H	THR17
H	CYS18
H	PHE28
H	TYR32
H	PRO34
H	THR35
H	GLY60
H	LYS116
H	ASP118
H	LEU119
H	SER158
H	ALA159
H	LEU160
H	MG202
H	HOH207
H	HOH215
H	HOH217
H	HOH219
H	HOH225
H	HOH239
H	HOH247
H	HOH263
H	HOH306
M	GLN27
M	HOH595

---

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO F 1301

Chain	Residue
F	PRO29
F	GLU31
F	TYR32
F	ILE33
F	GCP200
F	HOH1373

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 1302

Chain	Residue
C	THR17
C	GLU31
C	TYR32
C	ILE33
C	GCP200
C	HOH1407

---

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 1303

Chain	Residue
D	THR17
D	GLU31
D	TYR32
D	ILE33
D	GCP200
D	HOH1364

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Glycosylation: {"description":"O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24684802","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	104
Details	Domain: {"description":"CRIB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00057","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN61

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
F	GLN61

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLN61

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLN61

---

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
G	GLN61

---

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	GLN61

---

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
E	GLN61

---

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
H	GLN61

---