Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

2OUY

crystal structure of pde10a2 mutant D564A in complex with cAMP.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN A 777
ChainResidue
AHOH1
AHOH2
AHIS529
AHIS563
AASN564
AASP674

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 778
ChainResidue
AHOH5
AHOH6
AASN564
AHOH1
AHOH3
AHOH4

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN B 777
ChainResidue
BHOH11
BHOH12
BHIS529
BHIS563
BASN564
BASP674

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG B 778
ChainResidue
BHOH11
BHOH13
BHOH14
BHOH15
BHOH16
BASN564
BTHR633

site_idAC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE CMP A 779
ChainResidue
AHOH2
AHOH6
AHOH8
AHOH224
AHIS525
ALEU635
ALEU675
AILE692
APHE696
AGLN726
APHE729
BLEU706

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues317
DetailsDomain: {"description":"PDEase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01192","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17389385","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

244349

PDB entries from 2025-11-05

PDB statisticsPDBj update infoContact PDBjnumon