Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2OUI

D275P mutant of alcohol dehydrogenase from protozoa Entamoeba histolytica

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0050009	molecular_function	isopropanol dehydrogenase (NADP+) activity
B	0005737	cellular_component	cytoplasm
B	0008270	molecular_function	zinc ion binding
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
B	0050009	molecular_function	isopropanol dehydrogenase (NADP+) activity
C	0005737	cellular_component	cytoplasm
C	0008270	molecular_function	zinc ion binding
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
C	0050009	molecular_function	isopropanol dehydrogenase (NADP+) activity
D	0005737	cellular_component	cytoplasm
D	0008270	molecular_function	zinc ion binding
D	0016491	molecular_function	oxidoreductase activity
D	0046872	molecular_function	metal ion binding
D	0050009	molecular_function	isopropanol dehydrogenase (NADP+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 361

Chain	Residue
A	CYS37
A	SER39
A	HIS59
A	ASP150
A	CAC1001

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NO3 A 3001

Chain	Residue
A	HOH5055
A	HOH5104
A	THR38
A	GLY176
A	PRO177
A	VAL178

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NO3 A 3003

Chain	Residue
A	LYS201
A	CYS204
A	ASP205
A	ASN217
C	GLU325
C	ILE351
C	HIS352

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC A 1001

Chain	Residue
A	CYS37
A	SER39
A	HIS59
A	ASP150
A	THR154
A	ZN361
A	EDO2001
A	HOH5042
B	MET285

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 361

Chain	Residue
B	CYS37
B	HIS59
B	ASP150
B	CAC1001

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NO3 B 3002

Chain	Residue
B	PRO24
B	GLY69
B	SER70
B	HOH5100

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC B 1001

Chain	Residue
A	MET285
B	CYS37
B	SER39
B	HIS59
B	ILE86
B	ASP150
B	THR154
B	ZN361
B	HOH5067

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 361

Chain	Residue
C	CYS37
C	HIS59
C	ASP150
C	CAC1001

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC C 1001

Chain	Residue
C	CYS37
C	SER39
C	HIS59
C	ILE86
C	ASP150
C	THR154
C	ZN361
C	HOH5052
D	MET285

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 361

Chain	Residue
D	CYS37
D	SER39
D	HIS59
D	ASP150
D	CAC1001

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NO3 D 3004

Chain	Residue
D	ASP139
D	SER310
D	HOH7222
D	HOH7251

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC D 1001

Chain	Residue
C	MET285
D	CYS37
D	SER39
D	HIS59
D	ILE86
D	ASP150
D	THR154
D	ZN361
D	HOH7023

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 7001

Chain	Residue
D	HIS59
D	GLU60
D	ALA61
D	VAL83

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 2001

Chain	Residue
A	SER39
A	VAL265
A	ASN266
A	TYR267
A	CAC1001
A	HOH5145

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 2003

Chain	Residue
A	GLY174
A	ILE175
A	GLY176
A	GLY198
A	SER199
A	ARG200
A	HOH5255
A	HOH5269

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 2007

Chain	Residue
D	HOH7065
A	GLU160
A	LEU189
A	EDO2008
D	LYS165
D	LEU166
D	HOH7020

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 2008

Chain	Residue
A	GLU160
A	ASN163
A	ILE164
A	LYS165
A	EDO2007
A	HOH5078
A	HOH5165

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGE A 5001

Chain	Residue
A	LYS2
A	GLU328

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 2004

Chain	Residue
B	ASP89
B	TRP90
B	GLY91
B	GLU128
B	HOH5030
B	HOH5217

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 2005

Chain	Residue
B	GLN96
D	EDO2009

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 2006

Chain	Residue
B	GLU160
B	ASN163
B	ILE164
B	LYS165
B	HOH5170

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE B 5003

Chain	Residue
B	LYS2
B	TRP14
B	GLU328

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE B 5004

Chain	Residue
B	GLU160
B	LEU161
B	HIS291
B	HOH5246
B	HOH5247

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 2002

Chain	Residue
C	GLU160
C	ASN163
C	ILE164
C	LEU189
C	HOH5201

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE C 4001

Chain	Residue
A	ASP205
C	LYS2
C	TRP14
C	GLU16
C	GLU122
C	GLU328

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE C 5002

Chain	Residue
A	SER95
A	GLN96
C	SER95
C	GLN96
C	GLY98

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO D 2009

Chain	Residue
B	EDO2005
D	GLY98

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PG4 D 6001

Chain	Residue
D	LYS2
D	TRP14
D	GLU328

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaVGQivkvGslV

Chain	Residue	Details
A	GLY58-VAL72

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:20102159

Chain	Residue	Details
A	THR43
C	ILE65
C	VAL66
C	PHE156
D	THR43
D	ILE65
D	VAL66
D	PHE156
A	ILE65
A	VAL66
A	PHE156
B	THR43
B	ILE65
B	VAL66
B	PHE156
C	THR43

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	MET181
B	LYS346
C	MET181
C	CYS204
C	VAL224
C	GLY271
C	LYS346
D	MET181
D	CYS204
D	VAL224
D	GLY271
A	CYS204
D	LYS346
A	VAL224
A	GLY271
A	LYS346
B	MET181
B	CYS204
B	VAL224
B	GLY271

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1qlh

Chain	Residue	Details
A	HIS42
A	SER39

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1qlh

Chain	Residue	Details
B	HIS42
B	SER39

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1qlh

Chain	Residue	Details
C	HIS42
C	SER39

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1qlh

Chain	Residue	Details
D	HIS42
D	SER39

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)