2OTC
ORNITHINE TRANSCARBAMOYLASE COMPLEXED WITH N-(PHOSPHONACETYL)-L-ORNITHINE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0006591 | biological_process | ornithine metabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0019240 | biological_process | citrulline biosynthetic process |
| A | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006526 | biological_process | arginine biosynthetic process |
| B | 0006591 | biological_process | ornithine metabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0019240 | biological_process | citrulline biosynthetic process |
| B | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006526 | biological_process | arginine biosynthetic process |
| C | 0006591 | biological_process | ornithine metabolic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0019240 | biological_process | citrulline biosynthetic process |
| C | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006526 | biological_process | arginine biosynthetic process |
| D | 0006591 | biological_process | ornithine metabolic process |
| D | 0016597 | molecular_function | amino acid binding |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| D | 0019240 | biological_process | citrulline biosynthetic process |
| D | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0006526 | biological_process | arginine biosynthetic process |
| E | 0006591 | biological_process | ornithine metabolic process |
| E | 0016597 | molecular_function | amino acid binding |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| E | 0019240 | biological_process | citrulline biosynthetic process |
| E | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0006526 | biological_process | arginine biosynthetic process |
| F | 0006591 | biological_process | ornithine metabolic process |
| F | 0016597 | molecular_function | amino acid binding |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| F | 0019240 | biological_process | citrulline biosynthetic process |
| F | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006520 | biological_process | amino acid metabolic process |
| G | 0006526 | biological_process | arginine biosynthetic process |
| G | 0006591 | biological_process | ornithine metabolic process |
| G | 0016597 | molecular_function | amino acid binding |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| G | 0019240 | biological_process | citrulline biosynthetic process |
| G | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006520 | biological_process | amino acid metabolic process |
| H | 0006526 | biological_process | arginine biosynthetic process |
| H | 0006591 | biological_process | ornithine metabolic process |
| H | 0016597 | molecular_function | amino acid binding |
| H | 0016740 | molecular_function | transferase activity |
| H | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| H | 0019240 | biological_process | citrulline biosynthetic process |
| H | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006520 | biological_process | amino acid metabolic process |
| I | 0006526 | biological_process | arginine biosynthetic process |
| I | 0006591 | biological_process | ornithine metabolic process |
| I | 0016597 | molecular_function | amino acid binding |
| I | 0016740 | molecular_function | transferase activity |
| I | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| I | 0019240 | biological_process | citrulline biosynthetic process |
| I | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| I | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PAO A 334 |
| Chain | Residue |
| A | SER55 |
| A | ASP231 |
| A | SER235 |
| A | MET236 |
| A | LEU274 |
| A | ARG319 |
| A | HOH336 |
| C | GLN82 |
| A | THR56 |
| A | ARG57 |
| A | THR58 |
| A | ARG106 |
| A | LEU128 |
| A | HIS133 |
| A | ASN166 |
| A | ASN167 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PAO B 334 |
| Chain | Residue |
| A | GLN82 |
| B | SER55 |
| B | THR56 |
| B | ARG57 |
| B | THR58 |
| B | ARG106 |
| B | LEU128 |
| B | HIS133 |
| B | ASN166 |
| B | ASN167 |
| B | ASP231 |
| B | SER235 |
| B | MET236 |
| B | LEU274 |
| B | ARG319 |
| B | HOH337 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PAO C 334 |
| Chain | Residue |
| B | GLN82 |
| C | SER55 |
| C | THR56 |
| C | ARG57 |
| C | THR58 |
| C | ARG106 |
| C | LEU128 |
| C | HIS133 |
| C | ASN166 |
| C | ASN167 |
| C | ASP231 |
| C | SER235 |
| C | MET236 |
| C | LEU274 |
| C | ARG319 |
| C | HOH337 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PAO D 334 |
| Chain | Residue |
| D | SER55 |
| D | THR56 |
| D | ARG57 |
| D | THR58 |
| D | ARG106 |
| D | LEU128 |
| D | HIS133 |
| D | ASN166 |
| D | ASN167 |
| D | ASP231 |
| D | SER235 |
| D | MET236 |
| D | LEU274 |
| D | ARG319 |
| D | HOH336 |
| F | GLN82 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PAO E 334 |
| Chain | Residue |
| D | GLN82 |
| E | SER55 |
| E | THR56 |
| E | ARG57 |
| E | THR58 |
| E | ARG106 |
| E | LEU128 |
| E | HIS133 |
| E | ASN166 |
| E | ASN167 |
| E | ASP231 |
| E | SER235 |
| E | MET236 |
| E | LEU274 |
| E | ARG319 |
| E | HOH337 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PAO F 334 |
| Chain | Residue |
| E | GLN82 |
| F | SER55 |
| F | THR56 |
| F | ARG57 |
| F | THR58 |
| F | ARG106 |
| F | LEU128 |
| F | HIS133 |
| F | ASN166 |
| F | ASN167 |
| F | ASP231 |
| F | SER235 |
| F | MET236 |
| F | LEU274 |
| F | ARG319 |
| F | HOH337 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PAO G 334 |
| Chain | Residue |
| G | THR58 |
| G | ARG106 |
| G | LEU128 |
| G | HIS133 |
| G | ASN166 |
| G | ASN167 |
| G | ASP231 |
| G | SER235 |
| G | MET236 |
| G | LEU274 |
| G | ARG319 |
| G | HOH336 |
| I | GLN82 |
| G | SER55 |
| G | THR56 |
| G | ARG57 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PAO H 334 |
| Chain | Residue |
| G | GLN82 |
| H | SER55 |
| H | THR56 |
| H | ARG57 |
| H | THR58 |
| H | ARG106 |
| H | LEU128 |
| H | HIS133 |
| H | ASN166 |
| H | ASN167 |
| H | ASP231 |
| H | SER235 |
| H | MET236 |
| H | LEU274 |
| H | ARG319 |
| H | HOH337 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PAO I 334 |
| Chain | Residue |
| H | GLN82 |
| I | SER55 |
| I | THR56 |
| I | ARG57 |
| I | THR58 |
| I | ARG106 |
| I | LEU128 |
| I | HIS133 |
| I | ASN166 |
| I | ASN167 |
| I | ASP231 |
| I | SER235 |
| I | MET236 |
| I | LEU274 |
| I | ARG319 |
| I | HOH337 |
Functional Information from PROSITE/UniProt
| site_id | PS00097 |
| Number of Residues | 8 |
| Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FeKdSTRT |
| Chain | Residue | Details |
| A | PHE51-THR58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 63 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10747936, ECO:0000269|PubMed:9275160, ECO:0007744|PDB:1DUV, ECO:0007744|PDB:2OTC |
| Chain | Residue | Details |
| A | THR56 | |
| B | GLY107 | |
| B | PRO134 | |
| B | MET168 | |
| B | VAL232 | |
| B | MET236 | |
| C | THR56 | |
| C | ILE83 | |
| C | GLY107 | |
| C | PRO134 | |
| C | MET168 | |
| A | ILE83 | |
| C | VAL232 | |
| C | MET236 | |
| D | THR56 | |
| D | ILE83 | |
| D | GLY107 | |
| D | PRO134 | |
| D | MET168 | |
| D | VAL232 | |
| D | MET236 | |
| E | THR56 | |
| A | GLY107 | |
| E | ILE83 | |
| E | GLY107 | |
| E | PRO134 | |
| E | MET168 | |
| E | VAL232 | |
| E | MET236 | |
| F | THR56 | |
| F | ILE83 | |
| F | GLY107 | |
| F | PRO134 | |
| A | PRO134 | |
| F | MET168 | |
| F | VAL232 | |
| F | MET236 | |
| G | THR56 | |
| G | ILE83 | |
| G | GLY107 | |
| G | PRO134 | |
| G | MET168 | |
| G | VAL232 | |
| G | MET236 | |
| A | MET168 | |
| H | THR56 | |
| H | ILE83 | |
| H | GLY107 | |
| H | PRO134 | |
| H | MET168 | |
| H | VAL232 | |
| H | MET236 | |
| I | THR56 | |
| I | ILE83 | |
| I | GLY107 | |
| A | VAL232 | |
| I | PRO134 | |
| I | MET168 | |
| I | VAL232 | |
| I | MET236 | |
| A | MET236 | |
| B | THR56 | |
| B | ILE83 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:2405164 |
| Chain | Residue | Details |
| A | LEU274 | |
| B | LEU274 | |
| C | LEU274 | |
| D | LEU274 | |
| E | LEU274 | |
| F | LEU274 | |
| G | LEU274 | |
| H | LEU274 | |
| I | LEU274 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10747936, ECO:0007744|PDB:1DUV |
| Chain | Residue | Details |
| A | MET320 | |
| B | MET320 | |
| C | MET320 | |
| D | MET320 | |
| E | MET320 | |
| F | MET320 | |
| G | MET320 | |
| H | MET320 | |
| I | MET320 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| A | GLN136 | |
| A | CYS273 | |
| A | ASP231 | |
| A | ARG106 | |
| A | HIS133 | |
| A | ARG319 |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| A | THR58 | |
| A | ARG106 | |
| A | HIS133 | |
| A | ARG57 |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| B | THR58 | |
| B | ARG106 | |
| B | HIS133 | |
| B | ARG57 |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| C | THR58 | |
| C | ARG106 | |
| C | HIS133 | |
| C | ARG57 |
| site_id | CSA13 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| D | THR58 | |
| D | ARG106 | |
| D | HIS133 | |
| D | ARG57 |
| site_id | CSA14 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| E | THR58 | |
| E | ARG106 | |
| E | HIS133 | |
| E | ARG57 |
| site_id | CSA15 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| F | THR58 | |
| F | ARG106 | |
| F | HIS133 | |
| F | ARG57 |
| site_id | CSA16 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| G | THR58 | |
| G | ARG106 | |
| G | HIS133 | |
| G | ARG57 |
| site_id | CSA17 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| H | THR58 | |
| H | ARG106 | |
| H | HIS133 | |
| H | ARG57 |
| site_id | CSA18 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| I | THR58 | |
| I | ARG106 | |
| I | HIS133 | |
| I | ARG57 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| B | GLN136 | |
| B | CYS273 | |
| B | ASP231 | |
| B | ARG106 | |
| B | HIS133 | |
| B | ARG319 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| C | GLN136 | |
| C | CYS273 | |
| C | ASP231 | |
| C | ARG106 | |
| C | HIS133 | |
| C | ARG319 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| D | GLN136 | |
| D | CYS273 | |
| D | ASP231 | |
| D | ARG106 | |
| D | HIS133 | |
| D | ARG319 |
| site_id | CSA5 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| E | GLN136 | |
| E | CYS273 | |
| E | ASP231 | |
| E | ARG106 | |
| E | HIS133 | |
| E | ARG319 |
| site_id | CSA6 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| F | GLN136 | |
| F | CYS273 | |
| F | ASP231 | |
| F | ARG106 | |
| F | HIS133 | |
| F | ARG319 |
| site_id | CSA7 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| G | GLN136 | |
| G | CYS273 | |
| G | ASP231 | |
| G | ARG106 | |
| G | HIS133 | |
| G | ARG319 |
| site_id | CSA8 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| H | GLN136 | |
| H | CYS273 | |
| H | ASP231 | |
| H | ARG106 | |
| H | HIS133 | |
| H | ARG319 |
| site_id | CSA9 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| I | GLN136 | |
| I | CYS273 | |
| I | ASP231 | |
| I | ARG106 | |
| I | HIS133 | |
| I | ARG319 |
