Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004478 | molecular_function | methionine adenosyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0009087 | biological_process | L-methionine catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048269 | cellular_component | methionine adenosyltransferase complex |
| A | 0051259 | biological_process | protein complex oligomerization |
| A | 0051289 | biological_process | protein homotetramerization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA A 401 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 402 |
| Chain | Residue |
| A | GLU147 |
| A | GLU216 |
| A | LYS307 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE SAM A 501 |
| Chain | Residue |
| A | ASP116 |
| A | ILE117 |
| A | GLY133 |
| A | ASP134 |
| A | ASP179 |
| A | LYS181 |
| A | SER247 |
| A | ARG249 |
| A | PHE250 |
| A | ASP258 |
| A | LYS289 |
| A | HOH644 |
| A | HOH652 |
| A | HOH687 |
| A | HOH732 |
| A | HOH753 |
| A | HOH798 |
| A | HIS29 |
| A | PRO30 |
| A | ALA55 |
| A | GLU70 |
| A | GLN113 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PG4 A 601 |
| Chain | Residue |
| A | GLN190 |
| A | GLY193 |
| A | ARG313 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 A 602 |
| Chain | Residue |
| A | GLU148 |
| A | LYS159 |
| A | TYR377 |
| A | ARG382 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 A 603 |
| Chain | Residue |
| A | THR146 |
| A | GLU147 |
| A | GLU211 |
| A | ASP212 |
| A | ILE213 |
| A | LYS307 |
| A | HOH738 |
Functional Information from PROSITE/UniProt
| site_id | PS00376 |
| Number of Residues | 11 |
| Details | ADOMET_SYNTHASE_1 S-adenosylmethionine synthase signature 1. GAGDQGlmfGY |
| Chain | Residue | Details |
| A | GLY131-TYR141 | |
| site_id | PS00377 |
| Number of Residues | 9 |
| Details | ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD |
| Chain | Residue | Details |
| A | GLY278-ASP286 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Region: {"description":"Flexible loop","evidences":[{"source":"UniProtKB","id":"P0A817","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P13444","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"23425511","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2OBV","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A817","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"P0A817","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P13444","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1fug |
| Chain | Residue | Details |
| A | ASP291 | |
| A | LYS285 | |
| A | LYS289 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1fug |
| Chain | Residue | Details |
| A | ARG264 | |
| A | LYS181 | |
| A | LYS265 | |
| A | HIS29 | |
