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2O7Q

Crystal Structure of the A. thaliana DHQ-dehydroshikimate-SDH-shikimate-NADP(H)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003855molecular_function3-dehydroquinate dehydratase activity
A0004764molecular_functionshikimate 3-dehydrogenase (NADP+) activity
A0019632biological_processshikimate metabolic process
A0050661molecular_functionNADP binding
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1403
ChainResidue
ATRP158
APRO527
AHOH9243

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1402
ChainResidue
AASN483
AARG484
ATHR485

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1401
ChainResidue
ALYS385
AGLU386
AGLY462
AGLY463
AHOH9320
AILE382
APRO383
AHIS384

site_idAC4
Number of Residues12
DetailsBINDING SITE FOR RESIDUE DHK A 9241
ChainResidue
AGLU124
AARG126
AARG155
AHIS214
ALYS241
ALEU269
AARG279
APHE291
ASER300
AALA301
AGLN304
AHOH9259

site_idAC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE DHK A 4733
ChainResidue
AILE328
ASER336
ASER338
ASER379
ATHR381
ALYS385
AASN406
AASP423
ATYR550
AGLN578
AGLN582
AHOH9388

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor; for 3-dehydroquinate dehydratase activity => ECO:0000305|PubMed:16784230
ChainResidueDetails
AHIS214

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity => ECO:0000305|PubMed:16784230
ChainResidueDetails
ALYS241

site_idSWS_FT_FI3
Number of Residues2
DetailsACT_SITE: For shikimate dehydrogenase activity => ECO:0000305|PubMed:16784230
ChainResidueDetails
ALYS385
AASP423

site_idSWS_FT_FI4
Number of Residues7
DetailsBINDING: BINDING => ECO:0000269|DOI:10.1021/cg7007107, ECO:0007744|PDB:2O7Q
ChainResidueDetails
AGLU124
AARG126
AARG155
ALYS241
AARG279
ASER300
AGLN304

site_idSWS_FT_FI5
Number of Residues9
DetailsBINDING: BINDING => ECO:0000269|PubMed:16784230, ECO:0007744|PDB:2GPT
ChainResidueDetails
ASER336
ASER338
ATHR381
ALYS385
AASN406
AASP423
ATYR550
AGLN578
AGLN582

site_idSWS_FT_FI6
Number of Residues9
DetailsBINDING: BINDING => ECO:0000269|DOI:10.1021/cg7007107, ECO:0007744|PDB:2O7S
ChainResidueDetails
AALA461
AGLY463
AALA464
AASN483
ATHR485
AARG488
AMET525
AALA548
AGLY571

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1qfe
ChainResidueDetails
ALYS241
AHIS214
AGLU159

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1qfe
ChainResidueDetails
AASP414

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PDB entries from 2024-10-30

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