2O72

Crystal Structure Analysis of human E-cadherin (1-213)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005886	cellular_component	plasma membrane
A	0007155	biological_process	cell adhesion
A	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
A	0016020	cellular_component	membrane
A	0098609	biological_process	cell-cell adhesion

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 401

Chain	Residue
A	ASN102
A	ASN104
A	ASP134
A	ASP136
A	ASN143
A	ASP195

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 402

Chain	Residue
A	GLN101
A	ASP103
A	ASP136
A	GLU11
A	GLU69
A	ASP100

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 403

Chain	Residue
A	GLU11
A	ASP67
A	GLU69
A	ASP103
A	HOH428
A	HOH479

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 404

Chain	Residue
A	GLN110
A	GLU119
A	ASP180
A	CA405
A	HOH624
A	HOH639

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 405

Chain	Residue
A	GLU119
A	ARG181
A	GLU182
A	ASP213
A	CA404
A	HOH546
A	HOH624

---

Functional Information from PROSITE/UniProt

site_id	PS00232
Number of Residues	11
Details	CADHERIN_1 Cadherin domain signature. ItVtDqNDNkP

Chain	Residue	Details
A	ILE96-PRO106

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	ASP103
A	ASP134

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by S.pyogenes SpeB => ECO:0000269|PubMed:23532847

Chain	Residue	Details
A	THR210

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: O-linked (Man...) serine => ECO:0000250|UniProtKB:P09803

Chain	Residue	Details
A	SER126

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: O-linked (Man...) threonine => ECO:0000250|UniProtKB:P09803

Chain	Residue	Details
A	THR131
A	THR204

---