2O6G

Crystal structure of IRF-3 bound to the interferon-b enhancer

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0006355	biological_process	regulation of DNA-templated transcription
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0006355	biological_process	regulation of DNA-templated transcription
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00601
Number of Residues	33
Details	IRF_1 IRF tryptophan pentad repeat DNA-binding domain signature. WvNksrtrFrIPWkHglrqdaqqe.DfgIFQaWA

Chain	Residue	Details
E	TRP26-ALA58

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	424
Details	DNA binding: {"description":"IRF tryptophan pentad repeat","evidences":[{"source":"PROSITE-ProRule","id":"PRU00840","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	64
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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