2O6G
Crystal structure of IRF-3 bound to the interferon-b enhancer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| E | 0000976 | molecular_function | transcription cis-regulatory region binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0000976 | molecular_function | transcription cis-regulatory region binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0000976 | molecular_function | transcription cis-regulatory region binding |
| G | 0003700 | molecular_function | DNA-binding transcription factor activity |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| H | 0000976 | molecular_function | transcription cis-regulatory region binding |
| H | 0003700 | molecular_function | DNA-binding transcription factor activity |
| H | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PROSITE/UniProt
| site_id | PS00601 |
| Number of Residues | 33 |
| Details | IRF_1 IRF tryptophan pentad repeat DNA-binding domain signature. WvNksrtrFrIPWkHglrqdaqqe.DfgIFQaWA |
| Chain | Residue | Details |
| E | TRP26-ALA58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 424 |
| Details | DNA_BIND: IRF tryptophan pentad repeat => ECO:0000255|PROSITE-ProRule:PRU00840 |
| Chain | Residue | Details |
| E | LYS5-ASN111 | |
| F | LYS5-ASN111 | |
| G | LYS5-ASN111 | |
| H | LYS5-ASN111 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by CASP3 => ECO:0000269|PubMed:30878284 |
| Chain | Residue | Details |
| E | ASP121 | |
| F | ASP121 | |
| G | ASP121 | |
| H | ASP121 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:23746807 |
| Chain | Residue | Details |
| E | THR3 | |
| E | THR75 | |
| F | THR3 | |
| F | THR75 | |
| G | THR3 | |
| G | THR75 | |
| H | THR3 | |
| H | THR75 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:23746807 |
| Chain | Residue | Details |
| E | SER14 | |
| E | SER97 | |
| F | SER14 | |
| F | SER97 | |
| G | SER14 | |
| G | SER97 | |
| H | SER14 | |
| H | SER97 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70671 |
| Chain | Residue | Details |
| E | SER123 | |
| F | SER123 | |
| G | SER123 | |
| H | SER123 |
