2O5I

Crystal structure of the T. thermophilus RNA polymerase elongation complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0006351	biological_process	DNA-templated transcription
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046983	molecular_function	protein dimerization activity
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0006351	biological_process	DNA-templated transcription
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046983	molecular_function	protein dimerization activity
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0032549	molecular_function	ribonucleoside binding
C	0034062	molecular_function	5'-3' RNA polymerase activity
D	0000287	molecular_function	magnesium ion binding
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0034062	molecular_function	5'-3' RNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0034062	molecular_function	5'-3' RNA polymerase activity
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0006351	biological_process	DNA-templated transcription
K	0034062	molecular_function	5'-3' RNA polymerase activity
K	0046983	molecular_function	protein dimerization activity
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0006351	biological_process	DNA-templated transcription
L	0034062	molecular_function	5'-3' RNA polymerase activity
L	0046983	molecular_function	protein dimerization activity
M	0003677	molecular_function	DNA binding
M	0003899	molecular_function	DNA-directed RNA polymerase activity
M	0006351	biological_process	DNA-templated transcription
M	0032549	molecular_function	ribonucleoside binding
M	0034062	molecular_function	5'-3' RNA polymerase activity
N	0000287	molecular_function	magnesium ion binding
N	0003677	molecular_function	DNA binding
N	0003899	molecular_function	DNA-directed RNA polymerase activity
N	0005515	molecular_function	protein binding
N	0006351	biological_process	DNA-templated transcription
N	0008270	molecular_function	zinc ion binding
N	0034062	molecular_function	5'-3' RNA polymerase activity
O	0003677	molecular_function	DNA binding
O	0003899	molecular_function	DNA-directed RNA polymerase activity
O	0006351	biological_process	DNA-templated transcription
O	0034062	molecular_function	5'-3' RNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 4058

Chain	Residue
D	CYS58
D	ALA59
D	CYS60
D	CYS73
D	CYS76

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 6112

Chain	Residue
D	CYS1112
D	CYS1194
D	CYS1201
D	CYS1204

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN N 5058

Chain	Residue
D	SER1300
N	CYS58
N	ALA59
N	CYS60
N	CYS73
N	CYS76

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N 7112

Chain	Residue
N	CYS1112
N	CYS1194
N	CYS1201
N	CYS1204

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 8001

Chain	Residue
D	ASP739
D	ASP741
D	ASP743
H	G16

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG N 8002

Chain	Residue
N	ASP739
N	ASP741
N	ASP743
Y	G16

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	912
Details	Region: {"description":"Alpha N-terminal domain (alpha-NTD)","evidences":[{"source":"HAMAP-Rule","id":"MF_00059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AOI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---