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2O5D

Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-directed RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE VR1 A 600
ChainResidue
ALEU419
ATRP528
AVAL530
ALYS533
AHOH731
AHOH806
AARG422
AMET423
ALEU474
AHIS475
ASER476
ATYR477
AILE482
AALA486

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE VR1 B 600
ChainResidue
BLEU419
BARG422
BMET423
BLEU474
BHIS475
BSER476
BTYR477
BILE482
BALA486
BTRP528
BLYS533

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues236
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10557268","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11884572","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

249697

PDB entries from 2026-02-25

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