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2O5D

Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE VR1 A 600
ChainResidue
ALEU419
ATRP528
AVAL530
ALYS533
AHOH731
AHOH806
AARG422
AMET423
ALEU474
AHIS475
ASER476
ATYR477
AILE482
AALA486

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE VR1 B 600
ChainResidue
BLEU419
BARG422
BMET423
BLEU474
BHIS475
BSER476
BTYR477
BILE482
BALA486
BTRP528
BLYS533

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-05-01

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