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2O3K

Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004131molecular_functioncytosine deaminase activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0006139biological_processnucleobase-containing compound metabolic process
A0008270molecular_functionzinc ion binding
A0008655biological_processpyrimidine-containing compound salvage
A0008835molecular_functiondiaminohydroxyphosphoribosylaminopyrimidine deaminase activity
A0016787molecular_functionhydrolase activity
A0016814molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
A0019239molecular_functiondeaminase activity
A0019858biological_processcytosine metabolic process
A0044206biological_processUMP salvage
A0046087biological_processcytidine metabolic process
A0046872molecular_functionmetal ion binding
A0102480molecular_function5-fluorocytosine deaminase activity
B0003824molecular_functioncatalytic activity
B0004131molecular_functioncytosine deaminase activity
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0006139biological_processnucleobase-containing compound metabolic process
B0008270molecular_functionzinc ion binding
B0008655biological_processpyrimidine-containing compound salvage
B0008835molecular_functiondiaminohydroxyphosphoribosylaminopyrimidine deaminase activity
B0016787molecular_functionhydrolase activity
B0016814molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
B0019239molecular_functiondeaminase activity
B0019858biological_processcytosine metabolic process
B0044206biological_processUMP salvage
B0046087biological_processcytidine metabolic process
B0046872molecular_functionmetal ion binding
B0102480molecular_function5-fluorocytosine deaminase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 400
ChainResidue
BHIS262
BCYS291
BCYS294
BHPY410

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 401
ChainResidue
AHIS62
ACYS91
ACYS94
AHPY411

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 403
ChainResidue
AGLN150
AHOH423
AHOH435
BGLU275
AGLU128

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE HPY B 410
ChainResidue
BILE233
BASN251
BHIS262
BGLY263
BGLU264
BCYS291
BCYS294
BASP355
BZN400

site_idAC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE HPY A 411
ChainResidue
AILE33
AASN51
AHIS62
AGLY63
AGLU64
APRO90
ACYS91
ACYS94
AASP155
AZN401

Functional Information from PROSITE/UniProt
site_idPS00903
Number of Residues37
DetailsCYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HGEisTLencgrlegkvykdttlyttls............PCem......CtgaI
ChainResidueDetails
AHIS62-ILE98

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000269|PubMed:12637534, ECO:0007744|PDB:1UAQ
ChainResidueDetails
AGLU64
BGLU264

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:12637534, ECO:0000269|PubMed:12906827, ECO:0007744|PDB:1P6O, ECO:0007744|PDB:1UAQ
ChainResidueDetails
AASN51
AASP155
BASN251
BASP355

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:12637534, ECO:0000269|PubMed:12906827, ECO:0000269|PubMed:15879217, ECO:0007744|PDB:1OX7, ECO:0007744|PDB:1P6O, ECO:0007744|PDB:1RB7, ECO:0007744|PDB:1UAQ, ECO:0007744|PDB:1YSB, ECO:0007744|PDB:1YSD
ChainResidueDetails
AHIS62
ACYS91
ACYS94
BHIS262
BCYS291
BCYS294

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 636
ChainResidueDetails
AHIS62metal ligand
AGLU64proton acceptor, proton donor
ASER89electrostatic stabiliser
ACYS91metal ligand
ACYS94metal ligand

site_idMCSA2
Number of Residues5
DetailsM-CSA 636
ChainResidueDetails
BHIS262metal ligand
BGLU264proton acceptor, proton donor
BSER289electrostatic stabiliser
BCYS291metal ligand
BCYS294metal ligand

217705

PDB entries from 2024-03-27

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