Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2O3C

Crystal structure of zebrafish Ape

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001947	biological_process	heart looping
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006974	biological_process	DNA damage response
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
A	0010628	biological_process	positive regulation of gene expression
A	0016607	cellular_component	nuclear speck
A	0016787	molecular_function	hydrolase activity
A	0043066	biological_process	negative regulation of apoptotic process
A	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
A	0046872	molecular_function	metal ion binding
A	0052720	molecular_function	class II DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0060047	biological_process	heart contraction
A	0140431	molecular_function	DNA-(abasic site) binding
B	0001947	biological_process	heart looping
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006974	biological_process	DNA damage response
B	0008081	molecular_function	phosphoric diester hydrolase activity
B	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
B	0010628	biological_process	positive regulation of gene expression
B	0016607	cellular_component	nuclear speck
B	0016787	molecular_function	hydrolase activity
B	0043066	biological_process	negative regulation of apoptotic process
B	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
B	0046872	molecular_function	metal ion binding
B	0052720	molecular_function	class II DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0060047	biological_process	heart contraction
B	0140431	molecular_function	DNA-(abasic site) binding
C	0001947	biological_process	heart looping
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0003824	molecular_function	catalytic activity
C	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0006974	biological_process	DNA damage response
C	0008081	molecular_function	phosphoric diester hydrolase activity
C	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
C	0010628	biological_process	positive regulation of gene expression
C	0016607	cellular_component	nuclear speck
C	0016787	molecular_function	hydrolase activity
C	0043066	biological_process	negative regulation of apoptotic process
C	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
C	0046872	molecular_function	metal ion binding
C	0052720	molecular_function	class II DNA-(apurinic or apyrimidinic site) endonuclease activity
C	0060047	biological_process	heart contraction
C	0140431	molecular_function	DNA-(abasic site) binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PB C 401

Chain	Residue
B	GLU131
C	ASP63
C	GLU89
C	HOH424
C	HOH454
C	HOH464

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PB A 402

Chain	Residue
A	HOH453
C	GLU131
A	ASP63
A	ALA67
A	HOH438

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PB B 403

Chain	Residue
B	ASP63
B	GLU89
B	HOH473
B	HOH514

Functional Information from PROSITE/UniProt

site_id	PS00726
Number of Residues	10
Details	AP_NUCLEASE_F1_1 AP endonucleases family 1 signature 1. PDILCLQETK

Chain	Residue	Details
A	PRO82-LYS91

site_id	PS00728
Number of Residues	12
Details	AP_NUCLEASE_F1_3 AP endonucleases family 1 signature 3. NvGwRLDYfVlS

Chain	Residue	Details
A	ASN269-SER280

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	15
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Site: {"description":"Important for catalytic activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	3
Details	Site: {"description":"Interaction with DNA substrate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1ako

Chain	Residue	Details
A	ASN61
A	ASP275
A	ASP203
A	ASN205
A	HIS301

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 1ako

Chain	Residue	Details
B	ASN61
B	ASP275
B	ASP203
B	ASN205
B	HIS301

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 1ako

Chain	Residue	Details
C	ASN61
C	ASP275
C	ASP203
C	ASN205
C	HIS301

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)