2O2Y
The crystal structure of P. falciparum enoyl acyl carrier protein reductase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 709 |
| Chain | Residue |
| C | LEU143 |
| C | HOH758 |
| D | HIS215 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 710 |
| Chain | Residue |
| A | HIS215 |
| B | LEU143 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 711 |
| Chain | Residue |
| A | ASP142 |
| A | LEU143 |
| A | HOH743 |
| B | HIS215 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 712 |
| Chain | Residue |
| C | HIS215 |
| D | ASP142 |
| D | LEU143 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 713 |
| Chain | Residue |
| D | TYR59 |
| D | ASP65 |
| site_id | AC6 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAD B 1450 |
| Chain | Residue |
| B | ILE22 |
| B | GLY23 |
| B | GLY27 |
| B | TYR28 |
| B | TRP48 |
| B | PHE84 |
| B | ASP85 |
| B | ALA86 |
| B | SER87 |
| B | SER132 |
| B | LEU133 |
| B | ALA134 |
| B | ASN135 |
| B | LEU182 |
| B | THR183 |
| B | TYR184 |
| B | LYS202 |
| B | ALA229 |
| B | GLY230 |
| B | PRO231 |
| B | LEU232 |
| B | SER234 |
| B | ALA236 |
| B | TCL706 |
| B | HOH1471 |
| B | HOH1497 |
| B | HOH1515 |
| B | HOH1564 |
| site_id | AC7 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAD D 550 |
| Chain | Residue |
| D | ILE22 |
| D | GLY23 |
| D | GLY27 |
| D | TYR28 |
| D | TRP48 |
| D | PHE84 |
| D | ASP85 |
| D | ALA86 |
| D | SER87 |
| D | SER132 |
| D | LEU133 |
| D | ALA134 |
| D | ASN135 |
| D | LEU182 |
| D | THR183 |
| D | LYS202 |
| D | ALA229 |
| D | GLY230 |
| D | PRO231 |
| D | LEU232 |
| D | SER234 |
| D | ARG235 |
| D | ALA236 |
| D | TCL707 |
| D | HOH719 |
| D | HOH726 |
| D | HOH777 |
| D | HOH798 |
| D | HOH804 |
| site_id | AC8 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAD A 650 |
| Chain | Residue |
| A | HOH765 |
| A | HOH774 |
| A | HOH785 |
| A | GLY21 |
| A | ILE22 |
| A | GLY23 |
| A | GLY27 |
| A | TYR28 |
| A | TRP48 |
| A | PHE84 |
| A | ASP85 |
| A | ALA86 |
| A | SER132 |
| A | LEU133 |
| A | ALA134 |
| A | ASN135 |
| A | LYS157 |
| A | LEU182 |
| A | THR183 |
| A | TYR184 |
| A | LYS202 |
| A | ALA229 |
| A | GLY230 |
| A | PRO231 |
| A | LEU232 |
| A | SER234 |
| A | ALA236 |
| A | TCL705 |
| A | HOH720 |
| A | HOH726 |
| A | HOH756 |
| site_id | AC9 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAD C 750 |
| Chain | Residue |
| C | GLY23 |
| C | GLY27 |
| C | TYR28 |
| C | TRP48 |
| C | PHE84 |
| C | ASP85 |
| C | ALA86 |
| C | SER87 |
| C | SER132 |
| C | LEU133 |
| C | ALA134 |
| C | ASN135 |
| C | LEU182 |
| C | THR183 |
| C | TYR184 |
| C | LYS202 |
| C | ALA229 |
| C | GLY230 |
| C | PRO231 |
| C | LEU232 |
| C | SER234 |
| C | ARG235 |
| C | ALA236 |
| C | TCL708 |
| C | HOH759 |
| C | HOH769 |
| C | HOH802 |
| C | HOH814 |
| C | HOH828 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TCL A 705 |
| Chain | Residue |
| A | ALA134 |
| A | ALA136 |
| A | TYR184 |
| A | TYR194 |
| A | ALA236 |
| A | ALA237 |
| A | NAD650 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TCL B 706 |
| Chain | Residue |
| B | ALA134 |
| B | ALA136 |
| B | TYR184 |
| B | TYR194 |
| B | ALA236 |
| B | ALA237 |
| B | NAD1450 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TCL D 707 |
| Chain | Residue |
| D | ALA134 |
| D | ALA136 |
| D | TYR184 |
| D | TYR194 |
| D | ALA236 |
| D | ALA237 |
| D | ILE240 |
| D | NAD550 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TCL C 708 |
| Chain | Residue |
| C | ALA134 |
| C | ALA136 |
| C | TYR184 |
| C | TYR194 |
| C | ALA236 |
| C | ALA237 |
| C | NAD750 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qsg |
| Chain | Residue | Details |
| A | TYR194 | |
| A | LYS202 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qsg |
| Chain | Residue | Details |
| B | TYR194 | |
| B | LYS202 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qsg |
| Chain | Residue | Details |
| C | TYR194 | |
| C | LYS202 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qsg |
| Chain | Residue | Details |
| D | TYR194 | |
| D | LYS202 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qsg |
| Chain | Residue | Details |
| A | MET198 | |
| A | LYS202 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qsg |
| Chain | Residue | Details |
| B | MET198 | |
| B | LYS202 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qsg |
| Chain | Residue | Details |
| C | MET198 | |
| C | LYS202 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qsg |
| Chain | Residue | Details |
| D | MET198 | |
| D | LYS202 |
