Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2O2P

Crystal structure of the C-terminal domain of rat 10'formyltetrahydrofolate dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 3001

Chain	Residue
A	LYS852
C	ARG554

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 3002

Chain	Residue
A	ARG554
C	LYS852
C	HOH3110

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 3003

Chain	Residue
B	ARG554
B	HOH3388
D	LYS852
D	HOH3196

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 3004

Chain	Residue
B	ASP851
B	LYS852
B	HOH3141
D	ARG554

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 3005

Chain	Residue
B	ARG636
B	PRO641

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 3006

Chain	Residue
A	ARG636
A	PRO641

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 3007

Chain	Residue
C	ARG636
C	PRO641

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 3008

Chain	Residue
D	ARG636
D	PRO641

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 3009

Chain	Residue
B	ARG764

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 3010

Chain	Residue
C	ARG764
C	TYR799

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 3011

Chain	Residue
A	ARG764

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 3012

Chain	Residue
D	ARG764

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 3013

Chain	Residue
A	TYR848
C	ARG551
C	ARG554

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 3014

Chain	Residue
A	ARG551
A	ARG554
C	TYR848

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 3015

Chain	Residue
B	ARG551
B	ARG554
D	TYR848

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 3016

Chain	Residue
B	TYR848
D	ARG551
D	ARG554

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 3017

Chain	Residue
A	ASN548
A	HOH3158
A	HOH3285
A	HOH3438
B	GLN528

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 3018

Chain	Residue
A	GLN528
B	ASN548
B	HOH3186
B	HOH3306
B	HOH3331

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 3019

Chain	Residue
C	ASN548
C	HOH3282
C	HOH3446
C	HOH3512
D	GLN528

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 3020

Chain	Residue
A	ASN738
A	GLU741
A	ARG781
A	HOH3191
A	HOH3412
C	HOH3285

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 3021

Chain	Residue
B	THR445
B	ASN738
B	GLU741
B	ARG781
B	HOH3153

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 3022

Chain	Residue
C	ASN738
C	ARG781
C	HOH3071
C	HOH3513

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 3023

Chain	Residue
D	ASN738
D	GLU741
D	ARG781

site_id	CC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 3024

Chain	Residue
A	GLY881
A	LYS882
A	HOH3029
B	LYS669
B	LEU893
B	ARG894
B	ILE895
B	HOH3235

site_id	CC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 3025

Chain	Residue
A	LYS669
A	LEU893
A	ARG894
A	ILE895
A	HOH3034
A	HOH3326
A	HOH3478
B	GLY881
B	LYS882

site_id	CC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 D 3026

Chain	Residue
C	GLY881
C	LYS882
D	LYS669
D	LEU893
D	ARG894
D	ILE895
D	HOH3029
D	HOH3120
D	HOH3199
D	HOH3449

site_id	CC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 C 3027

Chain	Residue
C	LEU893
C	ARG894
C	ILE895
C	HOH3035
C	HOH3105
C	HOH3169
C	HOH3509
C	HOH3514
D	GLY881
D	LYS882
C	LYS669

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 3028

Chain	Residue
A	LEU416
A	THR417
A	HOH3428
C	LYS415
C	ARG742

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 2001

Chain	Residue
A	TYR575
A	ASN706
A	THR866

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 2002

Chain	Residue
B	TYR575
B	ASN706
B	THR866

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 2003

Chain	Residue
C	TYR575
C	ASN706
C	THR866

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 2004

Chain	Residue
D	TYR575
D	ASN706
D	ASN864
D	THR866

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNKGENCIAAG

Chain	Residue	Details
A	PHE700-GLY711

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP

Chain	Residue	Details
A	LEU672-PRO679

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1940
Details	Region: {"description":"Aldehyde dehydrogenase domain","evidences":[{"source":"PubMed","id":"10585460","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17302434","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"17302434","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21540484","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2O2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	44
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17302434","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21540484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2O2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O2R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17302434","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21540484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2O2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21540484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3RHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O75891","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8K009","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R0Y6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3SY69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
A	CYS707
A	ASN574
A	GLU673

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
B	CYS707
B	ASN574
B	GLU673

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
C	CYS707
C	ASN574
C	GLU673

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
D	CYS707
D	ASN574
D	GLU673

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
A	CYS707
A	LYS597
A	GLU804
A	GLU673

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
B	CYS707
B	LYS597
B	GLU804
B	GLU673

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
C	CYS707
C	LYS597
C	GLU804
C	GLU673

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
D	CYS707
D	LYS597
D	GLU804
D	GLU673

site_id	MCSA1
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
A	CYS707

site_id	MCSA2
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
B	CYS707

site_id	MCSA3
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
C	CYS707

site_id	MCSA4
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
D	CYS707

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)