Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2O20

Crystal structure of transcription regulator CcpA of Lactococcus lactis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0045892	biological_process	negative regulation of DNA-templated transcription
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0045892	biological_process	negative regulation of DNA-templated transcription
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0045892	biological_process	negative regulation of DNA-templated transcription
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription
E	0045892	biological_process	negative regulation of DNA-templated transcription
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0045892	biological_process	negative regulation of DNA-templated transcription
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0006355	biological_process	regulation of DNA-templated transcription
G	0045892	biological_process	negative regulation of DNA-templated transcription
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0006355	biological_process	regulation of DNA-templated transcription
H	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 2006

Chain	Residue
A	ARG303
A	LYS307
A	HOH2080
A	HOH2104
A	HOH2126
A	HOH2203

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 2007

Chain	Residue
A	HOH2056
A	PHE219
A	ARG234
A	ARG238

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 2001

Chain	Residue
B	GLU233
B	ARG234
B	LYS261
B	HOH2025
B	HOH2138

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 B 2003

Chain	Residue
B	SER128
B	GLY188
B	ASP192
B	GLU194
B	ASN195
B	ARG198
B	TYR223
B	HIS247
B	HOH2051
B	HOH2151
B	HOH2173
B	HOH2193

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 2004

Chain	Residue
E	GLU212
E	PHE213
E	HOH2122
E	HOH2149

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 2010

Chain	Residue
E	THR76

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 2002

Chain	Residue
B	LYS229
F	GLU233
F	ARG234
F	LYS261
F	HOH2109
F	HOH2138

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 2005

Chain	Residue
A	LYS174
F	LYS182
F	GLY239
F	HOH2073
F	HOH2080

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 G 2008

Chain	Residue
G	ARG303
G	LYS307
G	HOH2039
G	HOH2040
G	HOH2082
G	HOH2096

Functional Information from PROSITE/UniProt

site_id	PS00356
Number of Residues	19
Details	HTH_LACI_1 LacI-type HTH domain signature. IyDVArvAgVSmaTVsrVV

Chain	Residue	Details
A	ILE8-VAL26

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)