2O1O
Cryptosporidium parvum putative polyprenyl pyrophosphate synthase (cgd4_2550) in complex with risedronate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG B 501 |
| Chain | Residue |
| B | ASN254 |
| B | RIS400 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 502 |
| Chain | Residue |
| B | ASP115 |
| B | ASP119 |
| B | RIS400 |
| B | HOH518 |
| B | HOH519 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 503 |
| Chain | Residue |
| B | ASP187 |
| B | LYS273 |
| B | RIS400 |
| B | HOH520 |
| B | ASP115 |
| B | ASP119 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 501 |
| Chain | Residue |
| A | ASN254 |
| A | RIS400 |
| A | HOH511 |
| A | HOH513 |
| A | HOH514 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | ASP115 |
| A | ASP119 |
| A | GLN184 |
| A | ASP187 |
| A | RIS400 |
| A | MG503 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 503 |
| Chain | Residue |
| A | ASP115 |
| A | ASP119 |
| A | RIS400 |
| A | MG502 |
| A | HOH510 |
| A | HOH512 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE RIS B 400 |
| Chain | Residue |
| B | ASP115 |
| B | ASP119 |
| B | ARG124 |
| B | LYS210 |
| B | THR211 |
| B | GLN251 |
| B | ASN254 |
| B | LYS273 |
| B | MG501 |
| B | MG502 |
| B | MG503 |
| B | HOH514 |
| B | HOH518 |
| B | HOH519 |
| B | HOH520 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE RIS A 400 |
| Chain | Residue |
| A | ASP115 |
| A | ASP119 |
| A | ARG124 |
| A | GLN184 |
| A | LYS210 |
| A | THR211 |
| A | GLN251 |
| A | ASN254 |
| A | MG501 |
| A | MG502 |
| A | MG503 |
| A | HOH510 |
| A | HOH512 |
| A | HOH513 |
Functional Information from PROSITE/UniProt
| site_id | PS00723 |
| Number of Residues | 15 |
| Details | POLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LIaDDim..DsgkfRRG |
| Chain | Residue | Details |
| A | LEU112-GLY126 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| A | ARG124 | |
| A | TYR250 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| B | ARG124 | |
| B | TYR250 |
