2NY7
HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody b12
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| G | 0019031 | cellular_component | viral envelope |
| L | 0002250 | biological_process | adaptive immune response |
| L | 0002376 | biological_process | immune system process |
| L | 0003823 | molecular_function | antigen binding |
| L | 0005576 | cellular_component | extracellular region |
| L | 0005615 | cellular_component | extracellular space |
| L | 0005886 | cellular_component | plasma membrane |
| L | 0006955 | biological_process | immune response |
| L | 0016020 | cellular_component | membrane |
| L | 0016064 | biological_process | immunoglobulin mediated immune response |
| L | 0019814 | cellular_component | immunoglobulin complex |
| L | 0050853 | biological_process | B cell receptor signaling pathway |
| L | 0070062 | cellular_component | extracellular exosome |
| L | 0071735 | cellular_component | IgG immunoglobulin complex |
| L | 0071738 | cellular_component | IgD immunoglobulin complex |
| L | 0071742 | cellular_component | IgE immunoglobulin complex |
| L | 0071745 | cellular_component | IgA immunoglobulin complex |
| L | 0071753 | cellular_component | IgM immunoglobulin complex |
| L | 0072562 | cellular_component | blood microparticle |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR192-HIS198 | |
| H | TYR206-HIS212 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Region: {"description":"CD4-binding loop","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Region: {"description":"V5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Region: {"description":"V5","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19965434","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26972002","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11188697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14981267","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26972002","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11188697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14981267","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23539181","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26972002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9641677","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11188697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14981267","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26972002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9641677","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11188697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14981267","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9641677","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21998254","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26972002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9641677","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11188697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26972002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9641677","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17301785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965434","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2NY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IDX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IDY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11188697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14981267","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 97 |
| Details | Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
