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2NX5

Crystal structure of ELS4 TCR bound to HLA-B*3501 presenting EBV peptide EPLPQGQLTAY at 1.7A

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010038biological_processresponse to metal ion
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0033077biological_processT cell differentiation in thymus
B0033572biological_processtransferrin transport
B0034756biological_processregulation of iron ion transport
B0034757biological_processnegative regulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
G0000139cellular_componentGolgi membrane
G0001913biological_processT cell mediated cytotoxicity
G0001916biological_processpositive regulation of T cell mediated cytotoxicity
G0002237biological_processresponse to molecule of bacterial origin
G0002376biological_processimmune system process
G0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
G0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G0002502biological_processpeptide antigen assembly with MHC class I protein complex
G0002503biological_processpeptide antigen assembly with MHC class II protein complex
G0002726biological_processpositive regulation of T cell cytokine production
G0005198molecular_functionstructural molecule activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005765cellular_componentlysosomal membrane
G0005783cellular_componentendoplasmic reticulum
G0005788cellular_componentendoplasmic reticulum lumen
G0005794cellular_componentGolgi apparatus
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0005925cellular_componentfocal adhesion
G0006826biological_processiron ion transport
G0006879biological_processintracellular iron ion homeostasis
G0006955biological_processimmune response
G0007608biological_processsensory perception of smell
G0007611biological_processlearning or memory
G0009897cellular_componentexternal side of plasma membrane
G0009986cellular_componentcell surface
G0010038biological_processresponse to metal ion
G0010977biological_processnegative regulation of neuron projection development
G0012507cellular_componentER to Golgi transport vesicle membrane
G0016020cellular_componentmembrane
G0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
G0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
G0023026molecular_functionMHC class II protein complex binding
G0030670cellular_componentphagocytic vesicle membrane
G0031901cellular_componentearly endosome membrane
G0031902cellular_componentlate endosome membrane
G0031905cellular_componentearly endosome lumen
G0033077biological_processT cell differentiation in thymus
G0033572biological_processtransferrin transport
G0034756biological_processregulation of iron ion transport
G0034757biological_processnegative regulation of iron ion transport
G0035580cellular_componentspecific granule lumen
G0042026biological_processprotein refolding
G0042605molecular_functionpeptide antigen binding
G0042612cellular_componentMHC class I protein complex
G0042613cellular_componentMHC class II protein complex
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0042824cellular_componentMHC class I peptide loading complex
G0045646biological_processregulation of erythrocyte differentiation
G0048260biological_processpositive regulation of receptor-mediated endocytosis
G0048261biological_processnegative regulation of receptor-mediated endocytosis
G0050680biological_processnegative regulation of epithelial cell proliferation
G0050768biological_processnegative regulation of neurogenesis
G0050778biological_processpositive regulation of immune response
G0050870biological_processpositive regulation of T cell activation
G0051289biological_processprotein homotetramerization
G0055038cellular_componentrecycling endosome membrane
G0060586biological_processmulticellular organismal-level iron ion homeostasis
G0070062cellular_componentextracellular exosome
G0071281biological_processcellular response to iron ion
G0071283biological_processcellular response to iron(III) ion
G0071316biological_processcellular response to nicotine
G1904724cellular_componenttertiary granule lumen
G1990000biological_processamyloid fibril formation
G1990712cellular_componentHFE-transferrin receptor complex
G2000774biological_processpositive regulation of cellular senescence
G2000978biological_processnegative regulation of forebrain neuron differentiation
L0000139cellular_componentGolgi membrane
L0001913biological_processT cell mediated cytotoxicity
L0001916biological_processpositive regulation of T cell mediated cytotoxicity
L0002237biological_processresponse to molecule of bacterial origin
L0002376biological_processimmune system process
L0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
L0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
L0002502biological_processpeptide antigen assembly with MHC class I protein complex
L0002503biological_processpeptide antigen assembly with MHC class II protein complex
L0002726biological_processpositive regulation of T cell cytokine production
L0005198molecular_functionstructural molecule activity
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005615cellular_componentextracellular space
L0005765cellular_componentlysosomal membrane
L0005783cellular_componentendoplasmic reticulum
L0005788cellular_componentendoplasmic reticulum lumen
L0005794cellular_componentGolgi apparatus
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0005925cellular_componentfocal adhesion
L0006826biological_processiron ion transport
L0006879biological_processintracellular iron ion homeostasis
L0006955biological_processimmune response
L0007608biological_processsensory perception of smell
L0007611biological_processlearning or memory
L0009897cellular_componentexternal side of plasma membrane
L0009986cellular_componentcell surface
L0010038biological_processresponse to metal ion
L0010977biological_processnegative regulation of neuron projection development
L0012507cellular_componentER to Golgi transport vesicle membrane
L0016020cellular_componentmembrane
L0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
L0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
L0023026molecular_functionMHC class II protein complex binding
L0030670cellular_componentphagocytic vesicle membrane
L0031901cellular_componentearly endosome membrane
L0031902cellular_componentlate endosome membrane
L0031905cellular_componentearly endosome lumen
L0033077biological_processT cell differentiation in thymus
L0033572biological_processtransferrin transport
L0034756biological_processregulation of iron ion transport
L0034757biological_processnegative regulation of iron ion transport
L0035580cellular_componentspecific granule lumen
L0042026biological_processprotein refolding
L0042605molecular_functionpeptide antigen binding
L0042612cellular_componentMHC class I protein complex
L0042613cellular_componentMHC class II protein complex
L0042802molecular_functionidentical protein binding
L0042803molecular_functionprotein homodimerization activity
L0042824cellular_componentMHC class I peptide loading complex
L0045646biological_processregulation of erythrocyte differentiation
L0048260biological_processpositive regulation of receptor-mediated endocytosis
L0048261biological_processnegative regulation of receptor-mediated endocytosis
L0050680biological_processnegative regulation of epithelial cell proliferation
L0050768biological_processnegative regulation of neurogenesis
L0050778biological_processpositive regulation of immune response
L0050870biological_processpositive regulation of T cell activation
L0051289biological_processprotein homotetramerization
L0055038cellular_componentrecycling endosome membrane
L0060586biological_processmulticellular organismal-level iron ion homeostasis
L0070062cellular_componentextracellular exosome
L0071281biological_processcellular response to iron ion
L0071283biological_processcellular response to iron(III) ion
L0071316biological_processcellular response to nicotine
L1904724cellular_componenttertiary granule lumen
L1990000biological_processamyloid fibril formation
L1990712cellular_componentHFE-transferrin receptor complex
L2000774biological_processpositive regulation of cellular senescence
L2000978biological_processnegative regulation of forebrain neuron differentiation
R0000139cellular_componentGolgi membrane
R0001913biological_processT cell mediated cytotoxicity
R0001916biological_processpositive regulation of T cell mediated cytotoxicity
R0002237biological_processresponse to molecule of bacterial origin
R0002376biological_processimmune system process
R0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
R0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
R0002502biological_processpeptide antigen assembly with MHC class I protein complex
R0002503biological_processpeptide antigen assembly with MHC class II protein complex
R0002726biological_processpositive regulation of T cell cytokine production
R0005198molecular_functionstructural molecule activity
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005615cellular_componentextracellular space
R0005765cellular_componentlysosomal membrane
R0005783cellular_componentendoplasmic reticulum
R0005788cellular_componentendoplasmic reticulum lumen
R0005794cellular_componentGolgi apparatus
R0005829cellular_componentcytosol
R0005886cellular_componentplasma membrane
R0005925cellular_componentfocal adhesion
R0006826biological_processiron ion transport
R0006879biological_processintracellular iron ion homeostasis
R0006955biological_processimmune response
R0007608biological_processsensory perception of smell
R0007611biological_processlearning or memory
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0010038biological_processresponse to metal ion
R0010977biological_processnegative regulation of neuron projection development
R0012507cellular_componentER to Golgi transport vesicle membrane
R0016020cellular_componentmembrane
R0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
R0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
R0023026molecular_functionMHC class II protein complex binding
R0030670cellular_componentphagocytic vesicle membrane
R0031901cellular_componentearly endosome membrane
R0031902cellular_componentlate endosome membrane
R0031905cellular_componentearly endosome lumen
R0033077biological_processT cell differentiation in thymus
R0033572biological_processtransferrin transport
R0034756biological_processregulation of iron ion transport
R0034757biological_processnegative regulation of iron ion transport
R0035580cellular_componentspecific granule lumen
R0042026biological_processprotein refolding
R0042605molecular_functionpeptide antigen binding
R0042612cellular_componentMHC class I protein complex
R0042613cellular_componentMHC class II protein complex
R0042802molecular_functionidentical protein binding
R0042803molecular_functionprotein homodimerization activity
R0042824cellular_componentMHC class I peptide loading complex
R0045646biological_processregulation of erythrocyte differentiation
R0048260biological_processpositive regulation of receptor-mediated endocytosis
R0048261biological_processnegative regulation of receptor-mediated endocytosis
R0050680biological_processnegative regulation of epithelial cell proliferation
R0050768biological_processnegative regulation of neurogenesis
R0050778biological_processpositive regulation of immune response
R0050870biological_processpositive regulation of T cell activation
R0051289biological_processprotein homotetramerization
R0055038cellular_componentrecycling endosome membrane
R0060586biological_processmulticellular organismal-level iron ion homeostasis
R0070062cellular_componentextracellular exosome
R0071281biological_processcellular response to iron ion
R0071283biological_processcellular response to iron(III) ion
R0071316biological_processcellular response to nicotine
R1904724cellular_componenttertiary granule lumen
R1990000biological_processamyloid fibril formation
R1990712cellular_componentHFE-transferrin receptor complex
R2000774biological_processpositive regulation of cellular senescence
R2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
ChainResidueDetails
ATYR257-HIS263
BTYR78-HIS84

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues696
DetailsDomain: {"description":"Ig-like C1-type"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues356
DetailsRegion: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues364
DetailsRegion: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues364
DetailsRegion: {"description":"Alpha-3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues24
DetailsMotif: {"description":"Bw6 motif","evidences":[{"source":"PubMed","id":"25480565","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25808313","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues24
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues436
DetailsDomain: {"description":"Ig-like C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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