2NTI
Crystal structure of PCNA123 heterotrimer.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0006260 | biological_process | DNA replication |
| A | 0006272 | biological_process | leading strand elongation |
| A | 0006275 | biological_process | regulation of DNA replication |
| A | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0006260 | biological_process | DNA replication |
| B | 0006272 | biological_process | leading strand elongation |
| B | 0006275 | biological_process | regulation of DNA replication |
| B | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| C | 0003677 | molecular_function | DNA binding |
| C | 0006260 | biological_process | DNA replication |
| C | 0006272 | biological_process | leading strand elongation |
| C | 0006275 | biological_process | regulation of DNA replication |
| C | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| D | 0003677 | molecular_function | DNA binding |
| D | 0006260 | biological_process | DNA replication |
| D | 0006272 | biological_process | leading strand elongation |
| D | 0006275 | biological_process | regulation of DNA replication |
| D | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| E | 0003677 | molecular_function | DNA binding |
| E | 0006260 | biological_process | DNA replication |
| E | 0006272 | biological_process | leading strand elongation |
| E | 0006275 | biological_process | regulation of DNA replication |
| E | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| F | 0003677 | molecular_function | DNA binding |
| F | 0006260 | biological_process | DNA replication |
| F | 0006272 | biological_process | leading strand elongation |
| F | 0006275 | biological_process | regulation of DNA replication |
| F | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| G | 0003677 | molecular_function | DNA binding |
| G | 0006260 | biological_process | DNA replication |
| G | 0006272 | biological_process | leading strand elongation |
| G | 0006275 | biological_process | regulation of DNA replication |
| G | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| H | 0003677 | molecular_function | DNA binding |
| H | 0006260 | biological_process | DNA replication |
| H | 0006272 | biological_process | leading strand elongation |
| H | 0006275 | biological_process | regulation of DNA replication |
| H | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| I | 0003677 | molecular_function | DNA binding |
| I | 0006260 | biological_process | DNA replication |
| I | 0006272 | biological_process | leading strand elongation |
| I | 0006275 | biological_process | regulation of DNA replication |
| I | 0030337 | molecular_function | DNA polymerase processivity factor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR D 3015 |
| Chain | Residue |
| D | THR31 |
| D | GLU32 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR D 3016 |
| Chain | Residue |
| D | ASN17 |
| D | ASN21 |
| D | LYS210 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR D 3028 |
| Chain | Residue |
| D | ARG51 |
| D | PRO53 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR D 3037 |
| Chain | Residue |
| D | LYS129 |
| F | GLU54 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BR D 3039 |
| Chain | Residue |
| D | PHE215 |
| D | SER216 |
| D | ALA217 |
| D | ALA235 |
| D | VAL236 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR E 3001 |
| Chain | Residue |
| E | ASN27 |
| E | SER119 |
| E | THR120 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR E 3013 |
| Chain | Residue |
| E | GLU128 |
| E | PHE129 |
| E | PRO130 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR E 3017 |
| Chain | Residue |
| E | LEU127 |
| H | GLN116 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR E 3022 |
| Chain | Residue |
| E | ASN77 |
| E | HOH3069 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR E 3040 |
| Chain | Residue |
| E | ARG209 |
| E | HOH3116 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR E 3049 |
| Chain | Residue |
| E | PRO224 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR E 3050 |
| Chain | Residue |
| E | ASN94 |
| E | LYS97 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR F 3002 |
| Chain | Residue |
| F | LYS30 |
| F | GLN31 |
| F | GLU64 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR F 3005 |
| Chain | Residue |
| F | VAL244 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR F 3006 |
| Chain | Residue |
| F | LYS193 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR F 3012 |
| Chain | Residue |
| F | SER206 |
| F | LYS209 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR F 3021 |
| Chain | Residue |
| F | SER144 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR F 3023 |
| Chain | Residue |
| F | SER131 |
| F | THR133 |
| F | ASP185 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR F 3024 |
| Chain | Residue |
| F | ASN50 |
| F | GLY233 |
| F | LYS235 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR F 3030 |
| Chain | Residue |
| F | GLN225 |
| F | THR237 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR F 3034 |
| Chain | Residue |
| D | SER107 |
| F | SER135 |
| site_id | CC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR F 3041 |
| Chain | Residue |
| F | ASN50 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR A 3033 |
| Chain | Residue |
| A | ASN17 |
| A | LYS210 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 3043 |
| Chain | Residue |
| A | LYS76 |
| site_id | CC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR A 3044 |
| Chain | Residue |
| A | ARG51 |
| A | PRO53 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 3046 |
| Chain | Residue |
| A | GLY239 |
| site_id | CC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 3047 |
| Chain | Residue |
| A | TRP244 |
| site_id | DC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR B 3036 |
| Chain | Residue |
| B | LYS132 |
| B | GLU187 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 3038 |
| Chain | Residue |
| B | GLU74 |
| B | ASN77 |
| B | HOH3058 |
| site_id | DC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR B 3053 |
| Chain | Residue |
| E | LYS66 |
| site_id | DC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR C 3008 |
| Chain | Residue |
| C | ILE44 |
| C | VAL244 |
| site_id | DC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR C 3009 |
| Chain | Residue |
| C | LYS193 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR C 3018 |
| Chain | Residue |
| C | LYS140 |
| C | SER206 |
| C | LYS209 |
| site_id | DC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR C 3029 |
| Chain | Residue |
| C | SER131 |
| C | THR133 |
| C | ASP185 |
| site_id | DC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR C 3035 |
| Chain | Residue |
| C | ILE124 |
| C | THR237 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR C 3054 |
| Chain | Residue |
| C | LYS30 |
| C | GLN31 |
| C | GLU64 |
| site_id | EC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR G 3045 |
| Chain | Residue |
| G | LYS76 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR G 3052 |
| Chain | Residue |
| G | ASN17 |
| G | ASN21 |
| G | LYS210 |
| site_id | EC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR H 3004 |
| Chain | Residue |
| H | ARG244 |
| H | HOH4004 |
| site_id | EC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR H 3014 |
| Chain | Residue |
| H | GLU74 |
| H | ASN77 |
| site_id | EC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR H 3025 |
| Chain | Residue |
| H | LEU127 |
| H | LYS226 |
| H | TYR240 |
| site_id | EC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR H 3051 |
| Chain | Residue |
| H | ASN27 |
| H | THR120 |
| site_id | EC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE K H 4001 |
| Chain | Residue |
| H | 7PG2001 |
| site_id | EC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 7PG H 2001 |
| Chain | Residue |
| H | ARG44 |
| H | VAL45 |
| H | THR120 |
| H | GLN121 |
| H | TYR240 |
| H | K4001 |
| site_id | EC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR I 3003 |
| Chain | Residue |
| I | LYS30 |
| I | GLN31 |
| I | GLU64 |
| site_id | FC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR I 3007 |
| Chain | Residue |
| I | LYS193 |
| site_id | FC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR I 3011 |
| Chain | Residue |
| I | LYS243 |
| I | VAL244 |
| site_id | FC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR I 3019 |
| Chain | Residue |
| I | LYS209 |
| site_id | FC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR I 3032 |
| Chain | Residue |
| I | ARG53 |
| I | GLU54 |
| site_id | FC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR I 3048 |
| Chain | Residue |
| I | GLN72 |
| I | MET75 |
Functional Information from PROSITE/UniProt
| site_id | PS01251 |
| Number of Residues | 24 |
| Details | PCNA_1 Proliferating cell nuclear antigen signature 1. GIrVsGIDpSRVvFLdIfLpssyF |
| Chain | Residue | Details |
| E | GLY34-PHE57 | |
| F | SER33-PHE56 |
