Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 901 |
| Chain | Residue |
| A | GLU292 |
| A | ASP299 |
| A | VAL319 |
| A | ASP321 |
| A | GLU323 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 902 |
| Chain | Residue |
| B | GLU323 |
| B | GLU292 |
| B | ASP299 |
| B | VAL319 |
| B | ASP321 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 903 |
| Chain | Residue |
| A | VAL89 |
| A | GLY91 |
| A | ASP96 |
| A | GLU175 |
| A | HOH1060 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 904 |
| Chain | Residue |
| B | VAL89 |
| B | GLY91 |
| B | ASP96 |
| B | GLU175 |
| B | HOH996 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 905 |
| Chain | Residue |
| A | GLU292 |
| A | GLU320 |
| B | ARG311 |
| B | GLU314 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR CHAIN D OF LEUPEPTIN INHIBITOR |
| Chain | Residue |
| A | GLY103 |
| A | CYS105 |
| A | GLY197 |
| A | ALA250 |
| A | GLU251 |
| A | SER261 |
| A | HIS262 |
| A | ALA263 |
| B | TYR27 |
| B | LEU28 |
| B | LEU188 |
| B | ASN189 |
| B | GLY190 |
| D | HOH98 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR CHAIN E OF LEUPEPTIN INHIBITOR |
| Chain | Residue |
| A | TYR27 |
| A | LEU188 |
| A | GLY190 |
| B | GLY103 |
| B | CYS105 |
| B | GLY197 |
| B | SER261 |
| B | HIS262 |
| B | HOH1032 |
| E | HOH97 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGgLGDCWLlAA |
| Chain | Residue | Details |
| A | GLN99-ALA110 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 17 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| A | ASN286 | |
| A | HIS262 | |
| A | GLN99 | |
| A | CYS105 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| B | ASN286 | |
| B | HIS262 | |
| B | GLN99 | |
| B | CYS105 | |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| A | ASN286 | |
| A | HIS262 | |
| A | GLN99 | |
| A | CYS105 | |
| A | TRP288 | |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| B | ASN286 | |
| B | HIS262 | |
| B | GLN99 | |
| B | CYS105 | |
| B | TRP288 | |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 589 |
| Chain | Residue | Details |
| A | ILE111 | electrostatic stabiliser |
| A | ASN117 | electrostatic stabiliser |
| A | ILE282 | proton acceptor, proton donor |
| A | HIS306 | electrostatic stabiliser |
| A | ASP308 | steric role |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 589 |
| Chain | Residue | Details |
| B | ILE111 | electrostatic stabiliser |
| B | ASN117 | electrostatic stabiliser |
| B | ILE282 | proton acceptor, proton donor |
| B | HIS306 | electrostatic stabiliser |
| B | ASP308 | steric role |
2NQA
