2NOX

Crystal structure of tryptophan 2,3-dioxygenase from Ralstonia metallidurans

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
A	0006569	biological_process	L-tryptophan catabolic process
A	0009435	biological_process	NAD+ biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0019441	biological_process	L-tryptophan catabolic process to kynurenine
A	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
A	0019805	biological_process	quinolinate biosynthetic process
A	0020037	molecular_function	heme binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	1902494	cellular_component	catalytic complex
B	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
B	0006569	biological_process	L-tryptophan catabolic process
B	0009435	biological_process	NAD+ biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0019441	biological_process	L-tryptophan catabolic process to kynurenine
B	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
B	0019805	biological_process	quinolinate biosynthetic process
B	0020037	molecular_function	heme binding
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	1902494	cellular_component	catalytic complex
C	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
C	0006569	biological_process	L-tryptophan catabolic process
C	0009435	biological_process	NAD+ biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0019441	biological_process	L-tryptophan catabolic process to kynurenine
C	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
C	0019805	biological_process	quinolinate biosynthetic process
C	0020037	molecular_function	heme binding
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	1902494	cellular_component	catalytic complex
D	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
D	0006569	biological_process	L-tryptophan catabolic process
D	0009435	biological_process	NAD+ biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0019441	biological_process	L-tryptophan catabolic process to kynurenine
D	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
D	0019805	biological_process	quinolinate biosynthetic process
D	0020037	molecular_function	heme binding
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity
D	1902494	cellular_component	catalytic complex
E	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
E	0006569	biological_process	L-tryptophan catabolic process
E	0009435	biological_process	NAD+ biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0019441	biological_process	L-tryptophan catabolic process to kynurenine
E	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
E	0019805	biological_process	quinolinate biosynthetic process
E	0020037	molecular_function	heme binding
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0051213	molecular_function	dioxygenase activity
E	1902494	cellular_component	catalytic complex
F	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
F	0006569	biological_process	L-tryptophan catabolic process
F	0009435	biological_process	NAD+ biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0019441	biological_process	L-tryptophan catabolic process to kynurenine
F	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
F	0019805	biological_process	quinolinate biosynthetic process
F	0020037	molecular_function	heme binding
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0051213	molecular_function	dioxygenase activity
F	1902494	cellular_component	catalytic complex
G	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
G	0006569	biological_process	L-tryptophan catabolic process
G	0009435	biological_process	NAD+ biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0019441	biological_process	L-tryptophan catabolic process to kynurenine
G	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
G	0019805	biological_process	quinolinate biosynthetic process
G	0020037	molecular_function	heme binding
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
G	0051213	molecular_function	dioxygenase activity
G	1902494	cellular_component	catalytic complex
H	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
H	0006569	biological_process	L-tryptophan catabolic process
H	0009435	biological_process	NAD+ biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0019441	biological_process	L-tryptophan catabolic process to kynurenine
H	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
H	0019805	biological_process	quinolinate biosynthetic process
H	0020037	molecular_function	heme binding
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
H	0051213	molecular_function	dioxygenase activity
H	1902494	cellular_component	catalytic complex
I	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
I	0006569	biological_process	L-tryptophan catabolic process
I	0009435	biological_process	NAD+ biosynthetic process
I	0016491	molecular_function	oxidoreductase activity
I	0019441	biological_process	L-tryptophan catabolic process to kynurenine
I	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
I	0019805	biological_process	quinolinate biosynthetic process
I	0020037	molecular_function	heme binding
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
I	0051213	molecular_function	dioxygenase activity
I	1902494	cellular_component	catalytic complex
J	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
J	0006569	biological_process	L-tryptophan catabolic process
J	0009435	biological_process	NAD+ biosynthetic process
J	0016491	molecular_function	oxidoreductase activity
J	0019441	biological_process	L-tryptophan catabolic process to kynurenine
J	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
J	0019805	biological_process	quinolinate biosynthetic process
J	0020037	molecular_function	heme binding
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding
J	0051213	molecular_function	dioxygenase activity
J	1902494	cellular_component	catalytic complex
K	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
K	0006569	biological_process	L-tryptophan catabolic process
K	0009435	biological_process	NAD+ biosynthetic process
K	0016491	molecular_function	oxidoreductase activity
K	0019441	biological_process	L-tryptophan catabolic process to kynurenine
K	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
K	0019805	biological_process	quinolinate biosynthetic process
K	0020037	molecular_function	heme binding
K	0042802	molecular_function	identical protein binding
K	0046872	molecular_function	metal ion binding
K	0051213	molecular_function	dioxygenase activity
K	1902494	cellular_component	catalytic complex
L	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
L	0006569	biological_process	L-tryptophan catabolic process
L	0009435	biological_process	NAD+ biosynthetic process
L	0016491	molecular_function	oxidoreductase activity
L	0019441	biological_process	L-tryptophan catabolic process to kynurenine
L	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
L	0019805	biological_process	quinolinate biosynthetic process
L	0020037	molecular_function	heme binding
L	0042802	molecular_function	identical protein binding
L	0046872	molecular_function	metal ion binding
L	0051213	molecular_function	dioxygenase activity
L	1902494	cellular_component	catalytic complex
M	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
M	0006569	biological_process	L-tryptophan catabolic process
M	0009435	biological_process	NAD+ biosynthetic process
M	0016491	molecular_function	oxidoreductase activity
M	0019441	biological_process	L-tryptophan catabolic process to kynurenine
M	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
M	0019805	biological_process	quinolinate biosynthetic process
M	0020037	molecular_function	heme binding
M	0042802	molecular_function	identical protein binding
M	0046872	molecular_function	metal ion binding
M	0051213	molecular_function	dioxygenase activity
M	1902494	cellular_component	catalytic complex
N	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
N	0006569	biological_process	L-tryptophan catabolic process
N	0009435	biological_process	NAD+ biosynthetic process
N	0016491	molecular_function	oxidoreductase activity
N	0019441	biological_process	L-tryptophan catabolic process to kynurenine
N	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
N	0019805	biological_process	quinolinate biosynthetic process
N	0020037	molecular_function	heme binding
N	0042802	molecular_function	identical protein binding
N	0046872	molecular_function	metal ion binding
N	0051213	molecular_function	dioxygenase activity
N	1902494	cellular_component	catalytic complex
O	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
O	0006569	biological_process	L-tryptophan catabolic process
O	0009435	biological_process	NAD+ biosynthetic process
O	0016491	molecular_function	oxidoreductase activity
O	0019441	biological_process	L-tryptophan catabolic process to kynurenine
O	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
O	0019805	biological_process	quinolinate biosynthetic process
O	0020037	molecular_function	heme binding
O	0042802	molecular_function	identical protein binding
O	0046872	molecular_function	metal ion binding
O	0051213	molecular_function	dioxygenase activity
O	1902494	cellular_component	catalytic complex
P	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
P	0006569	biological_process	L-tryptophan catabolic process
P	0009435	biological_process	NAD+ biosynthetic process
P	0016491	molecular_function	oxidoreductase activity
P	0019441	biological_process	L-tryptophan catabolic process to kynurenine
P	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
P	0019805	biological_process	quinolinate biosynthetic process
P	0020037	molecular_function	heme binding
P	0042802	molecular_function	identical protein binding
P	0046872	molecular_function	metal ion binding
P	0051213	molecular_function	dioxygenase activity
P	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM A 500

Chain	Residue
A	PHE68
A	TYR148
A	ARG149
A	HIS257
A	VAL261
A	GLY270
A	GLY272
A	GLY273
A	THR274
A	TYR279
A	HOH502
A	GLN71
A	HOH513
A	HOH614
B	TYR43
A	HIS72
A	THR75
A	TRP119
A	LEU122
A	TYR130
A	SER141
A	GLY142

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM B 500

Chain	Residue
A	TYR43
B	PHE68
B	GLN71
B	HIS72
B	THR75
B	TRP119
B	LEU122
B	SER141
B	GLY142
B	PHE143
B	TYR148
B	ARG149
B	HIS257
B	VAL261
B	GLU275
B	GLY276
B	TYR279
B	LEU280
B	MET283
B	HOH502
B	HOH589

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM C 500

Chain	Residue
C	PHE68
C	GLN71
C	HIS72
C	THR75
C	TRP119
C	SER141
C	GLY142
C	PHE143
C	TYR148
C	ARG149
C	HIS257
C	VAL261
C	GLU275
C	GLY276
C	TYR279
C	LEU280
C	MET283
C	HOH512
D	TYR43

---

site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM D 500

Chain	Residue
C	TYR43
D	PHE68
D	GLN71
D	HIS72
D	THR75
D	TRP119
D	LEU122
D	SER141
D	GLY142
D	TYR148
D	ARG149
D	HIS257
D	VAL261
D	GLU275
D	GLY276
D	TYR279
D	LEU280
D	MET283
D	HOH505
D	HOH508
D	HOH585

---

site_id	AC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM E 500

Chain	Residue
E	MET283
E	HOH501
E	HOH506
E	HOH507
E	HOH554
E	HOH575
F	TYR43
E	PHE68
E	GLN71
E	HIS72
E	THR75
E	TRP119
E	LEU122
E	GLY142
E	PHE143
E	TYR148
E	ARG149
E	HIS257
E	VAL261
E	GLU275
E	GLY276
E	TYR279
E	LEU280

---

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM F 500

Chain	Residue
E	TYR43
F	PHE68
F	GLN71
F	HIS72
F	THR75
F	TRP119
F	LEU122
F	SER141
F	GLY142
F	PHE143
F	TYR148
F	ARG149
F	HIS257
F	VAL261
F	GLU275
F	GLY276
F	TYR279
F	LEU280
F	MET283
F	HOH506
F	HOH566

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM G 500

Chain	Residue
G	PHE68
G	HIS72
G	THR75
G	SER141
G	GLY142
G	PHE143
G	TYR148
G	ARG149
G	HIS257
G	VAL261
G	GLY276
G	TYR279
G	LEU280
G	MET283
G	HOH537
H	TYR43

---

site_id	AC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM H 500

Chain	Residue
G	TYR43
H	PHE68
H	GLN71
H	HIS72
H	THR75
H	TRP119
H	LEU122
H	SER141
H	GLY142
H	TYR148
H	ARG149
H	HIS257
H	VAL261
H	ILE265
H	GLU275
H	GLY276
H	TYR279
H	MET283
H	HOH504
H	HOH505
H	HOH586

---

site_id	AC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM I 500

Chain	Residue
I	PHE68
I	GLN71
I	HIS72
I	THR75
I	TRP119
I	LEU122
I	SER141
I	GLY142
I	TYR148
I	ARG149
I	HIS257
I	VAL261
I	GLY272
I	THR274
I	GLY276
I	TYR279
I	MET283
I	HOH507
I	HOH533
J	TYR43

---

site_id	BC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM J 500

Chain	Residue
I	TYR43
J	PHE68
J	GLN71
J	HIS72
J	THR75
J	TRP119
J	SER141
J	PHE143
J	TYR148
J	ARG149
J	HIS257
J	VAL261
J	GLY276
J	TYR279
J	MET283
J	HOH502

---

site_id	BC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM K 500

Chain	Residue
K	PHE68
K	GLN71
K	HIS72
K	THR75
K	TRP119
K	SER141
K	GLY142
K	PHE143
K	TYR148
K	ARG149
K	HIS257
K	VAL261
K	GLY276
K	TYR279
K	LEU280
K	HOH534
K	HOH537
L	TYR43

---

site_id	BC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM L 500

Chain	Residue
K	TYR43
L	PHE68
L	GLN71
L	HIS72
L	TRP119
L	SER141
L	GLY142
L	PHE143
L	TYR148
L	ARG149
L	HIS257
L	VAL261
L	GLU275
L	GLY276
L	TYR279
L	LEU280
L	MET283
L	HOH502
L	HOH518

---

site_id	BC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM M 500

Chain	Residue
M	PHE68
M	GLN71
M	HIS72
M	THR75
M	TRP119
M	LEU122
M	TYR130
M	SER141
M	GLY142
M	TYR148
M	ARG149
M	HIS257
M	VAL261
M	GLU275
M	GLY276
M	TYR279
M	LEU280
M	HOH501
M	HOH503
N	TYR43

---

site_id	BC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM N 500

Chain	Residue
M	TYR43
N	PHE68
N	GLN71
N	HIS72
N	THR75
N	TRP119
N	LEU122
N	SER141
N	GLY142
N	PHE143
N	TYR148
N	ARG149
N	HIS257
N	VAL261
N	GLU275
N	GLY276
N	TYR279
N	LEU280
N	MET283

---

site_id	BC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM O 500

Chain	Residue
O	PHE68
O	GLN71
O	HIS72
O	THR75
O	TRP119
O	SER141
O	GLY142
O	PHE143
O	TYR148
O	ARG149
O	HIS257
O	VAL261
O	GLY276
O	TYR279
O	LEU280
O	MET283
O	HOH522
O	HOH537
P	TYR43

---

site_id	BC7
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM P 500

Chain	Residue
O	TYR43
P	PHE68
P	GLN71
P	HIS72
P	THR75
P	TRP119
P	LEU122
P	SER141
P	GLY142
P	PHE143
P	TYR148
P	ARG149
P	HIS257
P	VAL261
P	ILE265
P	GLU275
P	GLY276
P	TYR279
P	MET283
P	HOH502
P	HOH515
P	HOH565
P	HOH588

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	104
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01972","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"HAMAP-Rule","id":"MF_01972","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---