Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006499 | biological_process | N-terminal protein myristoylation |
A | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE NHM A 500 |
Chain | Residue |
A | HIS38 |
A | PHE170 |
A | LEU171 |
A | CYS172 |
A | VAL173 |
A | ARG178 |
A | SER179 |
A | ARG181 |
A | LEU182 |
A | THR183 |
A | PRO184 |
A | LYS39 |
A | ILE187 |
A | THR191 |
A | TRP200 |
A | HIS201 |
A | ALA202 |
A | TYR204 |
A | THR205 |
A | PHE425 |
A | MIM700 |
A | HOH1003 |
A | PHE40 |
A | TRP41 |
A | ASN102 |
A | TYR103 |
A | VAL104 |
A | ILE168 |
A | ASN169 |
site_id | AC2 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE MIM A 700 |
Chain | Residue |
A | VAL104 |
A | ASP106 |
A | ASP108 |
A | PHE113 |
A | TYR115 |
A | ASN169 |
A | THR205 |
A | GLY207 |
A | TYR219 |
A | HIS221 |
A | PRO223 |
A | PHE234 |
A | THR235 |
A | PHE334 |
A | GLY416 |
A | ASP417 |
A | GLY418 |
A | LEU455 |
A | NHM500 |
A | HOH1016 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 801 |
Chain | Residue |
A | MET246 |
A | GLU249 |
A | GOL812 |
A | HOH1034 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 802 |
Chain | Residue |
A | ASP132 |
A | ASP245 |
A | GOL809 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 803 |
Chain | Residue |
A | CYS197 |
A | GOL809 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 804 |
Chain | Residue |
A | HIS296 |
A | HOH1043 |
A | HOH1055 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 805 |
Chain | Residue |
A | LYS263 |
A | PHE298 |
A | GLY300 |
A | ILE311 |
A | SER313 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 806 |
Chain | Residue |
A | ASP270 |
A | LYS291 |
A | ASP307 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 807 |
Chain | Residue |
A | PRO58 |
A | HIS201 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 808 |
Chain | Residue |
A | GLU80 |
A | TRP81 |
A | CYS82 |
A | SER83 |
A | GLN91 |
A | ARG138 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 809 |
Chain | Residue |
A | ASP132 |
A | THR242 |
A | GLU244 |
A | ASP245 |
A | GOL802 |
A | GOL803 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 810 |
Chain | Residue |
A | GLU317 |
A | PRO319 |
A | ASP320 |
A | GLY321 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 811 |
Chain | Residue |
A | ASP70 |
A | ASP70 |
A | LYS196 |
A | GLU244 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 812 |
Chain | Residue |
A | ASP85 |
A | HIS241 |
A | GLU249 |
A | GOL801 |
A | HOH1034 |
Functional Information from PROSITE/UniProt
site_id | PS00975 |
Number of Residues | 9 |
Details | NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCvHK |
Chain | Residue | Details |
A | GLU167-LYS175 | |
site_id | PS00976 |
Number of Residues | 7 |
Details | NMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGpGDG |
Chain | Residue | Details |
A | LYS412-GLY418 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | LEU455 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: |
Chain | Residue | Details |
A | HIS38 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | a catalytic site defined by CSA, PubMed 9846880, 10570244, 11371195, 11478885, 11527981 |
Chain | Residue | Details |
A | PHE170 | |
A | LEU455 | |
A | ASN169 | |
A | LEU171 | |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 928 |
Chain | Residue | Details |
A | ASN169 | electrostatic stabiliser |
A | PHE170 | electrostatic stabiliser |
A | LEU171 | electrostatic stabiliser |
A | THR205 | electrostatic stabiliser |
A | LEU455 | proton shuttle (general acid/base) |