2N9T
NMR solution structure of ProTx-II
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005246 | molecular_function | calcium channel regulator activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0008289 | molecular_function | lipid binding |
| A | 0017080 | molecular_function | sodium channel regulator activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 29 |
| Details | Peptide: {"description":"Beta/omega-theraphotoxin-Tp2a","featureId":"PRO_0000044556","evidences":[{"source":"PubMed","id":"12475222","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Region: {"description":"Flexible tail region important for ability to inhibit Nav channel","evidences":[{"source":"PubMed","id":"25026046","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Region: {"description":"Hydrophobic dyad that anchors the toxin into the membrane while positioning it over the S3 helix of Nav1.7/SCN9A","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Site: {"description":"Part of an aromatic-rich surface that anchors the toxin toward the membrane core relative to lipid headgroups bound along the pore module of Nav1.7/SCN9A","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Electrostatic gating-modifier of Nav1.7/SCN9A that antagonizes outward gating-charge movement through direct electrostatic repulsion; may also indirectly antagonize S4 gating-charge movement by neutralizing acidic side chains within the extracellular vestibule of VSD2","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Part of an aromatic-rich surface that anchors the toxin toward the membrane core relative to lipid headgroups bound along the pore module of Nav1.7/SCN9A; it also stabilizes the toxin for productive receptor site engagement","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Antagonizes outward gating-charge movement of Nav1.7/SCN9A through direct electrostatic repulsion; may also indirectly antagonize S4 gating-charge movement by neutralizing acidic side chains within the extracellular vestibule of VSD2","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
