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2MP1

Solution structure of the human chemokine CCL19

Functional Information from GO Data
ChainGOidnamespacecontents
A0001768biological_processestablishment of T cell polarity
A0001771biological_processimmunological synapse formation
A0002407biological_processdendritic cell chemotaxis
A0002408biological_processmyeloid dendritic cell chemotaxis
A0002606biological_processpositive regulation of dendritic cell antigen processing and presentation
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006874biological_processintracellular calcium ion homeostasis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007154biological_processcell communication
A0008009molecular_functionchemokine activity
A0009615biological_processresponse to virus
A0010560biological_processpositive regulation of glycoprotein biosynthetic process
A0030335biological_processpositive regulation of cell migration
A0031295biological_processT cell costimulation
A0031732molecular_functionCCR7 chemokine receptor binding
A0031735molecular_functionCCR10 chemokine receptor binding
A0032489biological_processregulation of Cdc42 protein signal transduction
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032735biological_processpositive regulation of interleukin-12 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0035022biological_processpositive regulation of Rac protein signal transduction
A0038119biological_processCCL19-activated CCR7 signaling pathway
A0042102biological_processpositive regulation of T cell proliferation
A0042379molecular_functionchemokine receptor binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0045627biological_processpositive regulation of T-helper 1 cell differentiation
A0045807biological_processpositive regulation of endocytosis
A0046330biological_processpositive regulation of JNK cascade
A0048020molecular_functionCCR chemokine receptor binding
A0048245biological_processeosinophil chemotaxis
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0048469biological_processcell maturation
A0050921biological_processpositive regulation of chemotaxis
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060491biological_processregulation of cell projection assembly
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0070098biological_processchemokine-mediated signaling pathway
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071380biological_processcellular response to prostaglandin E stimulus
A0071731biological_processresponse to nitric oxide
A0090023biological_processpositive regulation of neutrophil chemotaxis
A0097029biological_processmature conventional dendritic cell differentiation
A0098586biological_processcellular response to virus
A0141214biological_processpositive regulation of phospholipase C/protein kinase C signal transduction
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A2000147biological_processpositive regulation of cell motility
A2000549biological_processpositive regulation of dendritic cell dendrite assembly
A2000669biological_processnegative regulation of dendritic cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00472
Number of Residues44
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLsvtqkp..IpgyiVrnFhyllikdgCrvp.AVVFttlrgrql.CA
ChainResidueDetails
ACYS8-ALA51

237992

PDB entries from 2025-06-25

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