Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR CHAIN E OF INHIBITOR BI-LA-398 |
| Chain | Residue |
| A | ASP25 |
| A | ILE50 |
| A | PRO81 |
| A | ILE82 |
| A | ILE84 |
| B | ARG8 |
| B | ASP25 |
| B | GLY27 |
| B | ASP29 |
| B | GLY48 |
| B | GLY49 |
| A | GLY27 |
| B | ILE50 |
| D | TYR14 |
| E | HOH501 |
| G | PHE1 |
| G | VAL2 |
| G | PHE3 |
| G | LEU4 |
| G | GLU5 |
| G | ILE6 |
| G | NH27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | ILE32 |
| A | VAL47 |
| A | GLY48 |
| A | GLY49 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR CHAIN F OF INHIBITOR BI-LA-398 |
| Chain | Residue |
| B | ASN40 |
| B | ASN41 |
| B | GLU65 |
| C | LEU23 |
| C | ASP25 |
| C | GLY27 |
| C | ALA28 |
| C | ASP29 |
| C | GLY48 |
| C | GLY49 |
| C | ILE50 |
| C | ILE82 |
| C | ILE84 |
| D | ASP25 |
| D | GLY27 |
| D | ALA28 |
| D | ASP29 |
| D | ASP30 |
| D | VAL47 |
| D | GLY48 |
| D | GLY49 |
| D | PRO81 |
| D | ILE82 |
| F | HOH701 |
| H | PHE1 |
| H | VAL2 |
| H | PHE3 |
| H | LEU4 |
| H | GLU5 |
| H | ILE6 |
| H | NH27 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR CHAIN G OF INHIBITOR BI-LA-398 |
| Chain | Residue |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| A | PRO81 |
| A | ILE84 |
| B | ARG8 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | VAL47 |
| B | GLY48 |
| B | ILE50 |
| B | HOH505 |
| E | PHE1 |
| E | VAL2 |
| E | PHE3 |
| E | LEU4 |
| E | GLU5 |
| E | ILE6 |
| E | NH27 |
| E | HOH501 |
| site_id | AC4 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR CHAIN H OF INHIBITOR BI-LA-398 |
| Chain | Residue |
| C | GLY49 |
| C | ILE50 |
| C | ILE82 |
| D | ASP25 |
| D | GLY27 |
| D | ALA28 |
| D | ASP29 |
| D | VAL47 |
| D | GLY48 |
| D | GLY49 |
| D | ILE50 |
| D | PRO81 |
| D | ILE82 |
| F | PHE1 |
| F | VAL2 |
| F | PHE3 |
| F | LEU4 |
| F | GLU5 |
| F | ILE6 |
| F | NH27 |
| F | HOH701 |
| B | TYR14 |
| B | ASN40 |
| B | ASN41 |
| B | TYR42 |
| C | ASP25 |
| C | GLY27 |
| C | ALA28 |
| C | ASP29 |
| C | ASP30 |
| C | VAL47 |
| C | GLY48 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VLLDTGADDSIV |
| Chain | Residue | Details |
| A | VAL22-VAL33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by viral protease => ECO:0000250 |
| Chain | Residue | Details |
| A | ILE50 | |
| B | ILE50 | |
| C | ILE50 | |
| D | ILE50 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine; by host => ECO:0000250 |
| Chain | Residue | Details |
| A | ILE50 | |
| B | ILE50 | |
| C | ILE50 | |
| D | ILE50 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| B | ASP25 | |
| B | THR26 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| D | ASP25 | |
| D | THR26 | |
| C | ASP25 | |
| C | THR26 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP25 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| C | ASP25 | |
| D | ASP25 | |
