2M9Y

Solution Structure of the Catalytic Domain of HHARI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0008270	molecular_function	zinc ion binding
A	0016567	biological_process	protein ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	CYS344
A	CYS347
A	CYS362
A	CYS367

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 402

Chain	Residue
A	CYS372
A	CYS375
A	HIS382
A	CYS389

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	31
Details	ZN_FING: RING-type 2; atypical => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS344-CYS375

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:23707686

Chain	Residue	Details
A	SER357

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:15236971, ECO:0000269|PubMed:23707686, ECO:0000269|PubMed:24058416, ECO:0007744|PDB:1WD2, ECO:0007744|PDB:2M9Y, ECO:0007744|PDB:4KBL, ECO:0007744|PDB:4KC9

Chain	Residue	Details
A	CYS344
A	CYS347
A	CYS362
A	CYS367

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23707686, ECO:0000269|PubMed:24058416, ECO:0007744|PDB:2M9Y, ECO:0007744|PDB:4KBL, ECO:0007744|PDB:4KC9

Chain	Residue	Details
A	CYS372
A	CYS375
A	HIS382
A	CYS389

---