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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2M49

Structural Insights into Human S100B and Basic Fibroblast Growth Factor (FGF2) Interaction

Functional Information from GO Data
ChainGOidnamespacecontents
A0008083molecular_functiongrowth factor activity
B0001726cellular_componentruffle
B0005102molecular_functionsignaling receptor binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007155biological_processcell adhesion
B0007409biological_processaxonogenesis
B0007417biological_processcentral nervous system development
B0007611biological_processlearning or memory
B0008270molecular_functionzinc ion binding
B0008284biological_processpositive regulation of cell population proliferation
B0008360biological_processregulation of cell shape
B0031643biological_processpositive regulation of myelination
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0044548molecular_functionS100 protein binding
B0045471biological_processresponse to ethanol
B0045666biological_processpositive regulation of neuron differentiation
B0046872molecular_functionmetal ion binding
B0048156molecular_functiontau protein binding
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048708biological_processastrocyte differentiation
B0050786molecular_functionRAGE receptor binding
B0050806biological_processpositive regulation of synaptic transmission
B0051384biological_processresponse to glucocorticoid
B0051597biological_processresponse to methylmercury
B0060291biological_processlong-term synaptic potentiation
B0071456biological_processcellular response to hypoxia
B0072347biological_processresponse to anesthetic
B0097490biological_processsympathetic neuron projection extension
B1990138biological_processneuron projection extension
B1990845biological_processadaptive thermogenesis
B2001015biological_processnegative regulation of skeletal muscle cell differentiation
C0008083molecular_functiongrowth factor activity
D0001726cellular_componentruffle
D0005102molecular_functionsignaling receptor binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0007155biological_processcell adhesion
D0007409biological_processaxonogenesis
D0007417biological_processcentral nervous system development
D0007611biological_processlearning or memory
D0008270molecular_functionzinc ion binding
D0008284biological_processpositive regulation of cell population proliferation
D0008360biological_processregulation of cell shape
D0031643biological_processpositive regulation of myelination
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0044548molecular_functionS100 protein binding
D0045471biological_processresponse to ethanol
D0045666biological_processpositive regulation of neuron differentiation
D0046872molecular_functionmetal ion binding
D0048156molecular_functiontau protein binding
D0048306molecular_functioncalcium-dependent protein binding
D0048471cellular_componentperinuclear region of cytoplasm
D0048708biological_processastrocyte differentiation
D0050786molecular_functionRAGE receptor binding
D0050806biological_processpositive regulation of synaptic transmission
D0051384biological_processresponse to glucocorticoid
D0051597biological_processresponse to methylmercury
D0060291biological_processlong-term synaptic potentiation
D0071456biological_processcellular response to hypoxia
D0072347biological_processresponse to anesthetic
D0097490biological_processsympathetic neuron projection extension
D1990138biological_processneuron projection extension
D1990845biological_processadaptive thermogenesis
D2001015biological_processnegative regulation of skeletal muscle cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DNDGDGECDfqEF
ChainResidueDetails
BASP61-PHE73
site_idPS00247
Number of Residues24
DetailsHBGF_FGF HBGF/FGF family signature. GrLlAsksvtd.ECfFfErlesnnY
ChainResidueDetails
AGLY80-TYR103
site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. VMetLDndgDgecDFqEFmaFV
ChainResidueDetails
BVAL56-VAL77
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsRegion: {"description":"Heparin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsMotif: {"description":"Cell attachment site; atypical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsSite: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"28302677","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine; by TEC","evidences":[{"source":"PubMed","id":"20230531","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues70
DetailsDomain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues70
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20950652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CZT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20950652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D10","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20950652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D10","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20950652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D10","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"N-acetylserine; alternate","evidences":[{"source":"UniProtKB","id":"P02638","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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