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2M1K

Interaction of Human S100A6 (C3S) with V domain of Receptor for Advanced Glycation End products (RAGE)

Functional Information from GO Data
ChainGOidnamespacecontents
B0001726cellular_componentruffle
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005523molecular_functiontropomyosin binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007409biological_processaxonogenesis
B0008270molecular_functionzinc ion binding
B0009898cellular_componentcytoplasmic side of plasma membrane
B0015075molecular_functionmonoatomic ion transmembrane transporter activity
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
B0042803molecular_functionprotein homodimerization activity
B0044548molecular_functionS100 protein binding
B0046872molecular_functionmetal ion binding
B0048146biological_processpositive regulation of fibroblast proliferation
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
D0001726cellular_componentruffle
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005523molecular_functiontropomyosin binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005635cellular_componentnuclear envelope
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007409biological_processaxonogenesis
D0008270molecular_functionzinc ion binding
D0009898cellular_componentcytoplasmic side of plasma membrane
D0015075molecular_functionmonoatomic ion transmembrane transporter activity
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
D0042803molecular_functionprotein homodimerization activity
D0044548molecular_functionS100 protein binding
D0046872molecular_functionmetal ion binding
D0048146biological_processpositive regulation of fibroblast proliferation
D0048306molecular_functioncalcium-dependent protein binding
D0048471cellular_componentperinuclear region of cytoplasm
D0062023cellular_componentcollagen-containing extracellular matrix
D0070062cellular_componentextracellular exosome
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DRNKDQEVNfqEY
ChainResidueDetails
BASP61-TYR73

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. LMedLDrnkDqevNFqEYvtFL
ChainResidueDetails
BLEU56-LEU77

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN25
AASN81
CASN25
CASN81

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
BASP61
DGLU72
BASN63
BASP65
BGLU67
BGLU72
DASP61
DASN63
DASP65
DGLU67

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS40
DLYS40

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER46
DSER46

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P14069
ChainResidueDetails
BLYS47
DLYS47

218853

PDB entries from 2024-04-24

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