2L7M

Solution Structure of the Pitx2 Homeodomain R24H mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
P	0003677	molecular_function	DNA binding
P	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. IAvwTnLTeaRVRVWFkNrrakwR

Chain	Residue	Details
P	ILE34-ARG57

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	59
Details	DNA binding: {"description":"Homeobox","evidences":[{"source":"PROSITE-ProRule","id":"PRU00108","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PKB/AKT2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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