2KNC

Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005178	molecular_function	integrin binding
B	0007155	biological_process	cell adhesion
B	0007229	biological_process	integrin-mediated signaling pathway
B	0008305	cellular_component	integrin complex
B	0070527	biological_process	platelet aggregation

Functional Information from PROSITE/UniProt

site_id	PS00242
Number of Residues	8
Details	INTEGRIN_ALPHA Integrins alpha chain signature. WKvGFFkR

Chain	Residue	Details
A	TRP988-ARG995

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
B	ILE693-TRP715

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site_id	SWS_FT_FI2
Number of Residues	46
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
B	LYS716-THR762

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O54890

Chain	Residue	Details
B	THR741

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:19141530, ECO:0007744|PubMed:18088087

Chain	Residue	Details
B	TYR747

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PDPK1 and PKB/AKT1; in vitro => ECO:0000269|PubMed:10896934

Chain	Residue	Details
B	THR753

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:8631894

Chain	Residue	Details
B	TYR759

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