2KI6
The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| B | 0008083 | molecular_function | growth factor activity |
| C | 0001819 | biological_process | positive regulation of cytokine production |
| C | 0005507 | molecular_function | copper ion binding |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0017134 | molecular_function | fibroblast growth factor binding |
| C | 0032730 | biological_process | positive regulation of interleukin-1 alpha production |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| C | 0043303 | biological_process | mast cell degranulation |
| C | 0048306 | molecular_function | calcium-dependent protein binding |
| C | 0048471 | cellular_component | perinuclear region of cytoplasm |
| C | 0050786 | molecular_function | RAGE receptor binding |
| D | 0001819 | biological_process | positive regulation of cytokine production |
| D | 0005507 | molecular_function | copper ion binding |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0017134 | molecular_function | fibroblast growth factor binding |
| D | 0032730 | biological_process | positive regulation of interleukin-1 alpha production |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| D | 0043303 | biological_process | mast cell degranulation |
| D | 0048306 | molecular_function | calcium-dependent protein binding |
| D | 0048471 | cellular_component | perinuclear region of cytoplasm |
| D | 0050786 | molecular_function | RAGE receptor binding |
| E | 0008083 | molecular_function | growth factor activity |
| F | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00247 |
| Number of Residues | 24 |
| Details | HBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleenhY |
| Chain | Residue | Details |
| B | GLY64-TYR87 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 238 |
| Details | Domain: {"description":"C2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P46096","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P46096","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Region: {"description":"Heparin-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Motif: {"description":"Nuclear localization signal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11069186","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9655399","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P97352","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
