2KI6

The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
B	0008083	molecular_function	growth factor activity
C	0001819	biological_process	positive regulation of cytokine production
C	0005507	molecular_function	copper ion binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0008270	molecular_function	zinc ion binding
C	0008289	molecular_function	lipid binding
C	0015031	biological_process	protein transport
C	0017134	molecular_function	fibroblast growth factor binding
C	0032730	biological_process	positive regulation of interleukin-1 alpha production
C	0042803	molecular_function	protein homodimerization activity
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043303	biological_process	mast cell degranulation
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050786	molecular_function	RAGE receptor binding
D	0001819	biological_process	positive regulation of cytokine production
D	0005507	molecular_function	copper ion binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0008270	molecular_function	zinc ion binding
D	0008289	molecular_function	lipid binding
D	0015031	biological_process	protein transport
D	0017134	molecular_function	fibroblast growth factor binding
D	0032730	biological_process	positive regulation of interleukin-1 alpha production
D	0042803	molecular_function	protein homodimerization activity
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043303	biological_process	mast cell degranulation
D	0046872	molecular_function	metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0050786	molecular_function	RAGE receptor binding
E	0008083	molecular_function	growth factor activity
F	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00247
Number of Residues	24
Details	HBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleenhY

Chain	Residue	Details
B	GLY64-TYR87

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	238
Details	Domain: {"description":"C2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P46096","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P46096","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	32
Details	Region: {"description":"Heparin-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Motif: {"description":"Nuclear localization signal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11069186","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9655399","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	70
Details	Domain: {"description":"EF-hand"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P97352","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---