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2KI6

The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
B0008083molecular_functiongrowth factor activity
C0001819biological_processpositive regulation of cytokine production
C0005507molecular_functioncopper ion binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0008270molecular_functionzinc ion binding
C0008284biological_processpositive regulation of cell population proliferation
C0008289molecular_functionlipid binding
C0015031biological_processprotein transport
C0017134molecular_functionfibroblast growth factor binding
C0032730biological_processpositive regulation of interleukin-1 alpha production
C0042803molecular_functionprotein homodimerization activity
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043303biological_processmast cell degranulation
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050786molecular_functionRAGE receptor binding
D0001819biological_processpositive regulation of cytokine production
D0005507molecular_functioncopper ion binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0008270molecular_functionzinc ion binding
D0008284biological_processpositive regulation of cell population proliferation
D0008289molecular_functionlipid binding
D0015031biological_processprotein transport
D0017134molecular_functionfibroblast growth factor binding
D0032730biological_processpositive regulation of interleukin-1 alpha production
D0042803molecular_functionprotein homodimerization activity
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043303biological_processmast cell degranulation
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0048471cellular_componentperinuclear region of cytoplasm
D0050786molecular_functionRAGE receptor binding
E0008083molecular_functiongrowth factor activity
F0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00247
Number of Residues24
DetailsHBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleenhY
ChainResidueDetails
BGLY64-TYR87

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
DSER32
FLEU32
FASP33
FASP39
FASP91
FPHE92
FASP93
FSER96
FLYS97
FASP99
DGLU37
DASP64
DASN66
DASP68
DGLU70
DGLU75
ALYS97
AASP99

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97352
ChainResidueDetails
DSER32
FTYR90

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P46096
ChainResidueDetails
ASER125
FSER125

221716

PDB entries from 2024-06-26

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