2KA6

NMR structure of the CBP-TAZ2/STAT1-TAD complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003700	molecular_function	DNA-binding transcription factor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 93

Chain	Residue
A	HIS19
A	CYS23
A	ASN25

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 94

Chain	Residue
A	HIS42
A	THR43
A	CYS46
A	ARG48
A	LYS49

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 95

Chain	Residue
A	CYS71
A	HIS67

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	81
Details	Zinc finger: {"description":"TAZ-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00203","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q92793","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Required for recruitment of EP300/p300","evidences":[{"source":"PubMed","id":"16257975","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CAMK2 and MAPK14","evidences":[{"source":"PubMed","id":"11972023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15322115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16257975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17897103","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21135090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22065572","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26479788","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38621137","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7543024","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by IKKE","evidences":[{"source":"UniProtKB","id":"P42225","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by IKKB","evidences":[{"source":"PubMed","id":"32209697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38621137","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---