2K21

NMR structure of human KCNE1 in LMPG micelles at pH 6.0 and 40 degree C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005251	molecular_function	delayed rectifier potassium channel activity
A	0005267	molecular_function	potassium channel activity
A	0005515	molecular_function	protein binding
A	0005764	cellular_component	lysosome
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0007605	biological_process	sensory perception of sound
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0009986	cellular_component	cell surface
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0021750	biological_process	vestibular nucleus development
A	0030018	cellular_component	Z disc
A	0031433	molecular_function	telethonin binding
A	0033363	biological_process	secretory granule organization
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0042391	biological_process	regulation of membrane potential
A	0043266	biological_process	regulation of potassium ion transport
A	0044325	molecular_function	transmembrane transporter binding
A	0045121	cellular_component	membrane raft
A	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
A	0071320	biological_process	cellular response to cAMP
A	0071805	biological_process	potassium ion transmembrane transport
A	0086002	biological_process	cardiac muscle cell action potential involved in contraction
A	0086003	biological_process	cardiac muscle cell contraction
A	0086005	biological_process	ventricular cardiac muscle cell action potential
A	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
A	0086009	biological_process	membrane repolarization
A	0086011	biological_process	membrane repolarization during action potential
A	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
A	0086091	biological_process	regulation of heart rate by cardiac conduction
A	0090315	biological_process	negative regulation of protein targeting to membrane
A	0097623	biological_process	potassium ion export across plasma membrane
A	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1901381	biological_process	positive regulation of potassium ion transmembrane transport
A	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
A	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	62
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Region: {"description":"interaction with KCNQ1 C-terminus","evidences":[{"source":"PubMed","id":"25037568","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Interacts with the scolopendra toxin SSD609","evidences":[{"source":"PubMed","id":"26307551","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21669976","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21676880","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"21669976","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21676880","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---