2JLW

Dengue virus 4 NS3 helicase in complex with ssRNA2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A1619

Chain	Residue
A	GLY196
A	ALA197
A	GLY198
A	LYS199
A	THR200
A	ARG463
A	HOH2040

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 B1620

Chain	Residue
B	ALA197
B	GLY198
B	LYS199
B	THR200
B	ARG463
B	HOH2042
B	HIS194
B	GLY196

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B1619

Chain	Residue
B	TYR176
B	ALA602
D	U1

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	334
Details	Domain: {"description":"Helicase C-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"Important for RNA-binding","evidences":[{"source":"UniProtKB","id":"P14340","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Involved in NS3 ATPase and RTPase activities","evidences":[{"source":"UniProtKB","id":"P14335","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; by host","evidences":[{"source":"UniProtKB","id":"Q32ZE1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---