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2JLV

Dengue virus 4 NS3 helicase in complex with ssRNA and AMPPNP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004386molecular_functionhelicase activity
A0005524molecular_functionATP binding
B0004386molecular_functionhelicase activity
B0005524molecular_functionATP binding
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE ANP A1619
ChainResidue
APRO195
AGLY414
AASN416
AARG418
AARG460
AARG463
AMN1620
ACL1622
AHOH2087
AHOH2088
AHOH2345
AGLY196
AHOH2347
AHOH2348
AALA197
AGLY198
ALYS199
ATHR200
ALYS201
AGLU285
AASN329

site_idAC2
Number of Residues19
DetailsBINDING SITE FOR RESIDUE ANP B1619
ChainResidue
BPRO195
BGLY196
BALA197
BGLY198
BLYS199
BTHR200
BLYS201
BGLU285
BASN329
BGLY414
BASN416
BARG418
BARG460
BARG463
BMN1620
BCL1622
BHOH2209
BHOH2336
BHOH2339

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A1620
ChainResidue
ATHR200
AGLU285
AANP1619
AHOH2346
AHOH2347
AHOH2348

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN B1620
ChainResidue
BTHR200
BGLU285
BANP1619
BHOH2337
BHOH2338
BHOH2339

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A1621
ChainResidue
AGLY168
APRO174
ATYR176
ALEU443
AALA598
AALA602
AHOH2006
AHOH2349

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B1621
ChainResidue
BTYR176
BGLU177
BASP603
BHOH2146
DA1

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A1622
ChainResidue
AASN416
AARG418
AANP1619
AHOH2196

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL B1622
ChainResidue
BASN416
BARG418
BANP1619
BHOH2212

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541
ChainResidueDetails
ALEU193
BLEU193

site_idSWS_FT_FI2
Number of Residues4
DetailsSITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335
ChainResidueDetails
AARG457
AARG460
BARG457
BARG460

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P29990
ChainResidueDetails
ALYS618
BLYS618

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; by host => ECO:0000250|UniProtKB:Q32ZE1
ChainResidueDetails
ALYS388
BLYS388

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PDB entries from 2024-11-06

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