2JLS

Dengue virus 4 NS3 helicase in complex with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A1619

Chain	Residue
A	THR200
A	GLU285
A	ADP1620
A	HOH2236
A	HOH2237
A	HOH2238

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP A1620

Chain	Residue
A	LYS199
A	THR200
A	LYS201
A	ASN329
A	ARG463
A	MN1619
A	HOH2195
A	HOH2236
A	HOH2237
A	HOH2239
A	HOH2240
A	GLY196
A	ALA197
A	GLY198

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A1621

Chain	Residue
A	THR266
A	THR267
A	CYS292

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BME A1622

Chain	Residue
A	CYS261

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A1623

Chain	Residue
A	ARG387
A	THR408

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A1624

Chain	Residue
A	PRO318
A	PRO319
A	GLY320
A	SER321
A	ALA452
A	ASP482
A	LYS515
A	HOH2076
A	HOH2190
A	HOH2241
A	HOH2242

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	167
Details	Domain: {"description":"Helicase C-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Region: {"description":"Important for RNA-binding","evidences":[{"source":"UniProtKB","id":"P14340","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Involved in NS3 ATPase and RTPase activities","evidences":[{"source":"UniProtKB","id":"P14335","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by host","evidences":[{"source":"UniProtKB","id":"Q32ZE1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---