2JLS

Dengue virus 4 NS3 helicase in complex with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A1619

Chain	Residue
A	THR200
A	GLU285
A	ADP1620
A	HOH2236
A	HOH2237
A	HOH2238

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP A1620

Chain	Residue
A	LYS199
A	THR200
A	LYS201
A	ASN329
A	ARG463
A	MN1619
A	HOH2195
A	HOH2236
A	HOH2237
A	HOH2239
A	HOH2240
A	GLY196
A	ALA197
A	GLY198

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A1621

Chain	Residue
A	THR266
A	THR267
A	CYS292

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BME A1622

Chain	Residue
A	CYS261

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A1623

Chain	Residue
A	ARG387
A	THR408

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A1624

Chain	Residue
A	PRO318
A	PRO319
A	GLY320
A	SER321
A	ALA452
A	ASP482
A	LYS515
A	HOH2076
A	HOH2190
A	HOH2241
A	HOH2242

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	LEU193

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
A	ARG457
A	ARG460

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P29990

Chain	Residue	Details
A	LYS618

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by host => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
A	LYS388

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