2JLG

STRUCTURAL EXPLANATION FOR THE ROLE OF MN IN THE ACTIVITY OF PHI6 RNA-DEPENDENT RNA POLYMERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001172	biological_process	RNA-templated transcription
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0006351	biological_process	DNA-templated transcription
A	0019079	biological_process	viral genome replication
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication
A	0044423	cellular_component	virion component
A	0046872	molecular_function	metal ion binding
A	0050265	molecular_function	RNA uridylyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0001172	biological_process	RNA-templated transcription
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0006351	biological_process	DNA-templated transcription
B	0019079	biological_process	viral genome replication
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0039694	biological_process	viral RNA genome replication
B	0044423	cellular_component	virion component
B	0046872	molecular_function	metal ion binding
B	0050265	molecular_function	RNA uridylyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0001172	biological_process	RNA-templated transcription
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-dependent RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0019079	biological_process	viral genome replication
C	0034062	molecular_function	5'-3' RNA polymerase activity
C	0039694	biological_process	viral RNA genome replication
C	0044423	cellular_component	virion component
C	0046872	molecular_function	metal ion binding
C	0050265	molecular_function	RNA uridylyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GTP A1665

Chain	Residue
A	GLN206
A	ARG225
A	ARG268
A	ARG270
A	ASP327
A	TYR630

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GTP C1665

Chain	Residue
C	GTP1666
F	DC7
C	ARG204
C	ASP454
C	TYR630

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site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GTP C1666

Chain	Residue
C	ARG204
C	ARG225
C	ARG268
C	ARG270
C	ASP324
C	VAL325
C	SER326
C	ASP327
C	HIS328
C	ASP329
C	LEU391
C	SER393
C	ASP453
C	ASP454
C	GTP1665
C	MN1667
F	DC6
F	DC7

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C1667

Chain	Residue
C	ASP324
C	VAL325
C	SER326
C	ASP453
C	GTP1666

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site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GTP B1665

Chain	Residue
B	GLN206
B	ARG225
B	ARG268
B	ARG270
B	VAL325
B	HIS328
B	ASP453
B	TYR630

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING:

Chain	Residue	Details
A	ASP453
A	TYR490
A	GLY494
B	ASP453
B	TYR490
B	GLY494
C	ASP453
C	TYR490
C	GLY494

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