2JLA
Crystal structure of E.coli MenD, 2-succinyl-5-enolpyruvyl-6-hydroxy- 3-cyclohexadiene-1-carboxylate synthase - SeMet protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0009234 | biological_process | menaquinone biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0030976 | molecular_function | thiamine pyrophosphate binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0009234 | biological_process | menaquinone biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0030976 | molecular_function | thiamine pyrophosphate binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE TPP A 1557 |
| Chain | Residue |
| A | SER391 |
| A | SER444 |
| A | ASN469 |
| A | GLY471 |
| A | GLY472 |
| A | GLN473 |
| A | ILE474 |
| A | MN1558 |
| A | HOH2096 |
| A | HOH2097 |
| A | HOH2098 |
| A | LEU392 |
| B | PRO30 |
| B | GLU55 |
| B | THR81 |
| B | ALA82 |
| A | SER416 |
| A | GLY417 |
| A | ILE418 |
| A | ASP419 |
| A | GLY441 |
| A | ASP442 |
| A | LEU443 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 1558 |
| Chain | Residue |
| A | ASP442 |
| A | ASN469 |
| A | GLY471 |
| A | TPP1557 |
| A | HOH2098 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TPP B 1557 |
| Chain | Residue |
| A | PRO30 |
| A | GLU55 |
| A | THR81 |
| A | ALA82 |
| B | SER391 |
| B | LEU392 |
| B | SER416 |
| B | GLY417 |
| B | ILE418 |
| B | ASP419 |
| B | GLY441 |
| B | ASP442 |
| B | LEU443 |
| B | SER444 |
| B | TYR447 |
| B | ASN469 |
| B | GLY471 |
| B | GLY472 |
| B | GLN473 |
| B | ILE474 |
| B | MN1558 |
| B | HOH2099 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 1558 |
| Chain | Residue |
| B | ASP442 |
| B | ASN469 |
| B | GLY471 |
| B | TPP1557 |
| B | HOH2099 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE TPP C 1557 |
| Chain | Residue |
| C | SER391 |
| C | LEU392 |
| C | SER416 |
| C | GLY417 |
| C | ILE418 |
| C | ASP419 |
| C | GLY441 |
| C | ASP442 |
| C | LEU443 |
| C | SER444 |
| C | ASN469 |
| C | GLY471 |
| C | GLY472 |
| C | GLN473 |
| C | ILE474 |
| C | MN1558 |
| C | HOH2084 |
| C | HOH2085 |
| C | HOH2086 |
| D | PRO30 |
| D | GLU55 |
| D | THR81 |
| D | ALA82 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN C 1558 |
| Chain | Residue |
| C | ASP442 |
| C | ASN469 |
| C | GLY471 |
| C | TPP1557 |
| C | HOH2086 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TPP D 1557 |
| Chain | Residue |
| D | GLY471 |
| D | GLY472 |
| D | GLN473 |
| D | ILE474 |
| D | MN1558 |
| D | HOH2111 |
| C | PRO30 |
| C | GLU55 |
| C | THR81 |
| C | ALA82 |
| D | SER391 |
| D | LEU392 |
| D | SER416 |
| D | GLY417 |
| D | ILE418 |
| D | ASP419 |
| D | GLY441 |
| D | ASP442 |
| D | LEU443 |
| D | SER444 |
| D | TYR447 |
| D | ASN469 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN D 1558 |
| Chain | Residue |
| D | ASP442 |
| D | ASN469 |
| D | GLY471 |
| D | TPP1557 |
| D | HOH2111 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1559 |
| Chain | Residue |
| A | SER32 |
| A | ARG33 |
| A | THR78 |
| A | GLN118 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1559 |
| Chain | Residue |
| B | SER32 |
| B | ARG33 |
| B | THR78 |
| B | GLN118 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 1559 |
| Chain | Residue |
| C | GLY31 |
| C | SER32 |
| C | THR78 |
| C | GLN118 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 1559 |
| Chain | Residue |
| D | SER32 |
| D | THR78 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 1560 |
| Chain | Residue |
| A | PRO137 |
| A | ARG138 |
| C | ARG138 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 1560 |
| Chain | Residue |
| B | ARG138 |
| D | ARG138 |
| D | HOH2028 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1560 |
| Chain | Residue |
| A | ASN390 |
| A | SER391 |
| A | ARG395 |
| A | ARG413 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1561 |
| Chain | Residue |
| B | ASN390 |
| B | SER391 |
| B | ARG395 |
| B | ARG413 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 1561 |
| Chain | Residue |
| C | SER391 |
| C | ARG395 |
| C | ARG413 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 1560 |
| Chain | Residue |
| D | SER391 |
| D | ARG395 |
| D | ARG413 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN C 1562 |
| Chain | Residue |
| C | HIS509 |
| C | ASP523 |
| C | HOH2087 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1561 |
| Chain | Residue |
| A | GLU505 |
| D | HIS496 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1562 |
| Chain | Residue |
| B | LEU506 |
| B | LYS507 |
| B | THR530 |
| B | HOH2095 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 1561 |
| Chain | Residue |
| B | THR243 |
| D | THR243 |
