Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2JKZ

SACCHAROMYCES CEREVISIAE HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH GMP (GUANOSINE 5'- MONOPHOSPHATE) (ORTHORHOMBIC CRYSTAL FORM)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006166	biological_process	purine ribonucleoside salvage
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0032265	biological_process	XMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
A	1901576	biological_process	organic substance biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006166	biological_process	purine ribonucleoside salvage
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0032265	biological_process	XMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	1901576	biological_process	organic substance biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006166	biological_process	purine ribonucleoside salvage
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0032265	biological_process	XMP salvage
C	0046100	biological_process	hypoxanthine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	1901576	biological_process	organic substance biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006166	biological_process	purine ribonucleoside salvage
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0032265	biological_process	XMP salvage
D	0046100	biological_process	hypoxanthine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	1901576	biological_process	organic substance biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 5GP A 300

Chain	Residue
A	ASP110
A	TRP188
A	TYR189
A	TYR191
A	GLU194
A	GLU111
A	ASP114
A	THR115
A	ARG116
A	THR117
A	THR118
A	LYS159
A	LYS187

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	GLY38
A	GLY39
B	ARG45
B	ARG48

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 5GP B 300

Chain	Residue
B	ASP110
B	GLU111
B	ASP114
B	THR115
B	ARG116
B	THR117
B	THR118
B	LYS159
B	LYS187
B	TRP188
B	TYR189
B	TYR191
B	GLU194

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 301

Chain	Residue
A	ARG45
A	ARG48
B	GLY38
B	GLY39

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 5GP C 300

Chain	Residue
C	ASP110
C	GLU111
C	ASP114
C	THR115
C	ARG116
C	THR117
C	THR118
C	LYS159
C	LYS187
C	TRP188
C	TYR189
C	TYR191
C	GLU194

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 301

Chain	Residue
C	GLY38
C	GLY39
D	ARG45
D	ARG48

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 5GP D 300

Chain	Residue
D	ASP110
D	GLU111
D	ASP114
D	THR115
D	ARG116
D	THR117
D	THR118
D	LYS159
D	LYS187
D	TRP188
D	TYR189
D	TYR191
D	GLU194

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 301

Chain	Residue
C	ARG45
C	ARG48
D	GLY38
D	GLY39

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	ASP114
B	ASP114
C	ASP114
D	ASP114

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:18245832

Chain	Residue	Details
A	LYS85
C	ASP110
C	LYS159
C	TRP188
D	LYS85
D	ASP110
D	LYS159
D	TRP188
A	ASP110
A	LYS159
A	TRP188
B	LYS85
B	ASP110
B	LYS159
B	TRP188
C	LYS85

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylserine => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	SER2
B	SER2
C	SER2
D	SER2

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)