2JK4
Structure of the human voltage-dependent anion channel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001662 | biological_process | behavioral fear response |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005757 | cellular_component | mitochondrial permeability transition pore complex |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006820 | biological_process | monoatomic anion transport |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0007270 | biological_process | neuron-neuron synaptic transmission |
| A | 0007612 | biological_process | learning |
| A | 0008142 | molecular_function | oxysterol binding |
| A | 0008289 | molecular_function | lipid binding |
| A | 0008308 | molecular_function | voltage-gated monoatomic anion channel activity |
| A | 0015288 | molecular_function | porin activity |
| A | 0015485 | molecular_function | cholesterol binding |
| A | 0016020 | cellular_component | membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030855 | biological_process | epithelial cell differentiation |
| A | 0031210 | molecular_function | phosphatidylcholine binding |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0042645 | cellular_component | mitochondrial nucleoid |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043227 | cellular_component | membrane-bounded organelle |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0045121 | cellular_component | membrane raft |
| A | 0045202 | cellular_component | synapse |
| A | 0046930 | cellular_component | pore complex |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0097001 | molecular_function | ceramide binding |
| A | 0098656 | biological_process | monoatomic anion transmembrane transport |
| A | 0110099 | biological_process | negative regulation of calcium import into the mitochondrion |
| A | 1901524 | biological_process | regulation of mitophagy |
| A | 1903146 | biological_process | regulation of autophagy of mitochondrion |
| A | 1905091 | biological_process | positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization |
| A | 2000378 | biological_process | negative regulation of reactive oxygen species metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00558 |
| Number of Residues | 23 |
| Details | EUKARYOTIC_PORIN Eukaryotic mitochondrial porin signature. YqiDPdAcfsAKVNNssliGLgY |
| Chain | Residue | Details |
| A | TYR228-TYR250 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 164 |
| Details | TRANSMEM: Beta stranded => ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158 |
| Chain | Residue | Details |
| A | LEU29-SER38 | |
| A | LEU42-ALA50 | |
| A | VAL57-TRP67 | |
| A | LEU72-ASN79 | |
| A | THR83-ASP92 | |
| A | LEU98-SER107 | |
| A | ASN114-ARG123 | |
| A | ILE126-ASP133 | |
| A | SER140-GLY148 | |
| A | LEU153-GLU161 | |
| A | ARG166-THR178 | |
| A | PHE181-ASN188 | |
| A | GLU192-VAL201 | |
| A | LEU205-THR214 | |
| A | ARG221-ILE230 | |
| A | ALA234-ASN241 | |
| A | LEU245-LEU254 | |
| A | GLY257-LEU266 | |
| A | HIS276-GLN285 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18755977 |
| Chain | Residue | Details |
| A | LEU245 | |
| A | SER263 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Involved in ceramide and phosphatidylcholine binding. Critical for channel structural stability and gating => ECO:0000269|PubMed:31015432, ECO:0000305|PubMed:18832158 |
| Chain | Residue | Details |
| A | GLU76 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:2559745, ECO:0000269|Ref.12, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| A | ALA5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z2L0 |
| Chain | Residue | Details |
| A | SER16 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q60932 |
| Chain | Residue | Details |
| A | THR22 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q60932 |
| Chain | Residue | Details |
| A | LYS23 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q60932 |
| Chain | Residue | Details |
| A | TYR70 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR110 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q60932 |
| Chain | Residue | Details |
| A | LYS112 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by NEK1 => ECO:0000269|PubMed:20230784 |
| Chain | Residue | Details |
| A | SER196 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER243 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q60932 |
| Chain | Residue | Details |
| A | LYS255 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS269 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:32047033 |
| Chain | Residue | Details |
| A | LYS15 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25621951, ECO:0000269|PubMed:32047033 |
| Chain | Residue | Details |
| A | LYS56 | |
| A | LYS113 | |
| A | LYS277 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:32047033 |
| Chain | Residue | Details |
| A | LYS23 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25621951 |
| Chain | Residue | Details |
| A | LYS64 | |
| A | LYS164 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:25621951, ECO:0000269|PubMed:32047033 |
| Chain | Residue | Details |
| A | LYS112 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:25621951 |
| Chain | Residue | Details |
| A | LYS269 |
